Aneurysmal bone cysts express vascular markers

Pediatric and Developmental Pathology

Volumn 9, Issue 1, 2006, Pages 38-43

  Shinde, Anjali ^a   Mehlman, Charles T ^b   Collins, Margaret H ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Aneurysmal; Bone cysts; Immunohistochemistry; Pathogenesis; Vascular markers; VEGF

Indexed keywords

ACTIN ANTIBODY; ANTIBODY; ANTIGEN; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 ANTIBODY; CD34 ANTIGEN; CYTOKERATIN AE1; CYTOKERATIN AE3; CYTOKERATIN ANTIBODY; D2 40 ANTIBODY; D2 40 ANTIGEN; GLUCOSE TRANSPORTER 1; LYMPHOCYTE ANTIBODY; MARKER; PROTEIN ANTIBODY; SMOOTH MUSCLE ACTIN; UNCLASSIFIED DRUG; VASCULAR MARKER; VASCULOTROPIN ANTIBODY; VASCULOTROPIN C; ACTIN; BIOLOGICAL MARKER; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY D2 40; MONOCLONAL ANTIBODY D2-40;

ANEURYSMAL BONE CYST; ARTICLE; BONE LESION; CHROMOSOME ABERRATION; CONTROLLED STUDY; DISEASE MARKER; ENDOTHELIUM INJURY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PATHOGENESIS; PRIORITY JOURNAL; SPINDLE CELL; STAINING; VASCULARIZATION; METABOLISM; PATHOLOGY; VASCULAR ENDOTHELIUM;

ACTINS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD34; BIOLOGICAL MARKERS; BONE CYSTS, ANEURYSMAL; ENDOTHELIUM, VASCULAR; GLUCOSE TRANSPORTER TYPE 1; HUMANS; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 33746196588     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/06-05-0070.1     Document Type: Article

References (29)

1. Dorfman HD, Czerniak B, eds. Cystic lesions. In: Bone Tumors. St Louis: Mosby, 1998; 855-912.
2. Vergel de Dios AMV, Bond JR, Shives TC, McLeod RA, Unni KK. Aneurysmal bone cyst. A clinicopathologic study of 238 cases. Cancer 1992;69:2921-2931.
3. Rosenberg AE, Nielsen GP, Fletcher JA. Aneurysmal bone cyst. In: Fletcher CDM, Unni KK, Mertens F, eds. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press, 2002; 338-339.
4. Marcove RC, Sheth DS, Takemoto S, Healey JH. The treatment of aneurysmal bone cyst. Clin Orthop Rel Res 1995;11:157-163.
5. Jaffe H, Lichtenstein L. Solitary unicameral bone cyst with emphasis on the roentgen picture, the pathologic appearance, and the pathogenesis. Arch Surg 1942;44:1004-1025.
6. Panoutsakopoulos G, Pandis N, Kyriazogiou I, Gustafson P, Mertens F, Mandahl N. Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts. Genes Chromosomes Cancer 1999;26:264-266.
7. Dal Cin P, Kozakewich HP, Goumnerova L, Mankin JH, Rosenberg AE, Fletcher JA. Variant translocations involving 16q22 and 17p13 in solid variant and extraosseous forms of aneurysmal bone cyst. Genes Chromosomes Cancer 2000;28:233-234.
8. Sciot R, Dorfman H, Brys P, et al. Cytogenetic-morphologic correlations in aneurysmal bone cyst, giant cell tumor of bone and combined lesions. A report from the CHAMP study group. Mod Pathol 2000;13:1206-1210.
9. Oliveira AM, Hsi BL, Weremowicz S, et al. USP6(TRE2) fusion oncogenes in aneurysmal bone cyst. Cancer Res 2004;64:1920-1923.
10. Oliviera AM, Perez-Atayde AR, Inwards CY, et al. USP6 and CDHII oncogenes identify the neoplastic cell in primary bone cysts and are absent in so-called secondary aneurysmal bone cysts. Am J Pathol 2004;165:1773-1780.
11. Biesecker JL, Marcove RC, Huvos AG, Mike V. Aneurysmal bone cysts: a clinicopathologic study of 66 cases. Cancer 1970;26:615-625.
12. Clough JR, Price CH. Aneurysmal bone cyst: pathogenesis and long term results of treatment. Clin Orthop 1973;97:52-63.
13. Szendroi M, Arato G, Ezzati A, Hurtle K, Szavcsur P. Aneurysmal bone cyst: its pathogenesis based on angiographic, immunohistochemical and electron microscopic studies. Pathol Oncol Res 1998;4:277-281.
14. Aho HJ, Aho AJ, Pelliniemi LJ, Ekfors TO, Foidart JM. Endothelium in aneurysmal bone cyst. Histopathology 1985;9:381-387.
15. Alles JU, Schulz A. Immunocytochemical markers (endothelial and histiocytic) and ultrastrucrure of primary aneurysmal bone cysts. Hum Pathol 1986;1:39-45.
16. Vollmer E, Roessner A, Lipecki KH, Zwadlo G, Hagemeier HH, Grundmann E. Biologic characterization of human bone tumors. VI. The aneurysmal bone cyst: an enzyme histochemical, electron microscopical, and immunohistological study. Virchows Arch B Cell Pathol 1987;53:58-65.
17. Steiner GC, Kantor EB. Ultrastrucrure of aneurysmal bone cyst. Cancer 1977;40:2967-2978.
18. Aho HJ, Aho AL, Einola S. Aneurysmal bone cyst, a study of ultrastructure and malignant transformation. Virchows Arch A (Pathol Anat) 1982;395:169-179.
19. Engsig MT, Chen QJ, Vu TH, et al. Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol 2000;151:879-889.
20. Niida S, Kaku M, Tanne K, Maeda N. Vascular endothelial growth factor (VEGF) induces osteoclast differentiation in op/op mice. Bone 1998;23(Suppl):430.
21. Kumta SM, Huang L, Cheng YY, Chow LT, Lee KM, Zheng MH. Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesions. Life Sci 2003;73:1427-1436.
22. Joukov V, Pajusol A, Kaipainen A, et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J 1996;15:290-209.
23. Kahn HJ, Bailey D, Marks A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol 2002;15:434-440.
24. Fukunaga M. Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology 2005;46:396-402.
25. North PE, Waner M, Mizeracki A, Mihm M. GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol 2000;31:11-22.
26. Fina L, Molgaard H, Robertson D, et al. Expression of CD 34 gene in vascular endothelial cells. Blood 1990;75:2417-2426.
27. Frischer JS, Huang J, Serur A, Kadenhe A, Yamashiro DJ, Kandel JJ. Biomolecular markers and involution of hemangiomas. J Pediatr Surg 2004;39:400-404.
28. Ferrajoli A, Keating MJ, Manshouri T, et al. The clinical significance of tumor necrosis factor-alpha plasma level in patients having chronic lymphocytic leukemia. Blood 2002;100:1215-1219.
29. Wulf GG, Jahns-Streubel G, Hemmerlein B, Bonnekessen K, Wormann B, Hiddemann W. Plasmacytosis in acute myeloid leukemia: two cases of plasmacytosis and increased IL-6 production in the AML blast cells. Ann Hematol 1998;76:273-277.