Effects of estrogens on cognition and brain morphology: Involvement of the cerebellum

Maturitas

Volumn 54, Issue 3, 2006, Pages 222-228

  Ghidoni, R ^a   Boccardi, M ^a   Benussi, L ^a   Testa, C ^a   Villa, A ^a   Pievani, M ^a   Gigola, L ^a   Sabattoli, F ^a   Barbiero, L ^a   Frisoni, G B ^a   Binetti, G ^a  

^a IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

Author keywords

Aging; Brain morphology; Cerebellum; Cognition; ERT

Indexed keywords

ESTROGEN;

ADULT; AGED; AGING; APTITUDE TEST; ARTICLE; ATTENTION; BRAIN; CEREBELLUM; COGNITION; CONTROLLED STUDY; DEPTH PERCEPTION; DRUG EFFECT; ESTROGEN ACTIVITY; ESTROGEN THERAPY; GRAY MATTER; HUMAN; INTELLIGENCE; LANGUAGE; MEMORY; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL CORTEX; PARIETAL LOBE; POSTMENOPAUSE;

CASE-CONTROL STUDIES; CEREBELLUM; COGNITION; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POSTMENOPAUSE;

EID: 33746187171     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2005.11.002     Document Type: Article

References (38)

1. Schaie K.W. The course of adult intellectual development. Am Psychol 49 (1994) 304-313
2. Lindenberger U., and Baltes P.B. Intellectual functioning in old and very old age: cross-sectional results from the Berlin Aging Study. Psychol Aging 12 (1997) 410-432
3. Jacobs D.M., Tang M.X., Stern Y., et al. Cognitive function in nondemented older women who took estrogen after menopause. Neurology 50 (1998) 368-373
4. Drake E.B., Henderson V.W., Stanczyk F.Z., et al. Associations between circulating sex steroid hormones and cognition in normal elderly women. Neurology 54 (2000) 599-603
5. Rapp S.R., Espeland M.A., Shumaker S.A., et al. Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 289 (2003) 2663-2672
6. Shughrue P.J., Scrimo P.J., and Merchenthaler I. Estrogen binding and estrogen receptor characterization (ERα and ERβ) in the cholinergic neurons of the rat basal forebrain. Neuroscience 96 (2000) 41-49
7. Tsutsui K., Sakamoto H., Shikimi H., and Ukena K. Organizing actions of neurosteroids in the Purkinje neuron. Neurosci Res 49 (2004) 273-279
8. McEwen B.S., Alves S.E., Bulloch K., and Weiland N.G. Ovarian steroids and the brain: implications for cognition and aging. Neurology 48 (1997) S8-S15
9. Green P.S., Gridley K.E., and Simpkins J.W. Nuclear estrogen receptor-independent neuroprotection by estratrienes: a novel interaction with glutathione. Neuroscience 84 (1998) 7-10
10. Gould E., Woolley C.S., Frankfurt M., and McEwen B.S. Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J Neurosci 10 (1990) 1286-1291
11. Luine V.N. Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats. Exp Neurol 89 (1985) 484-490
12. Gandy S. Neurohormonal signaling pathways and the regulation of Alzheimer beta-amyloid precursor metabolism. Trends Endocrinol Metab 10 (1999) 273-279
13. Petanceska S.S. Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain. Exp Gerontol 35 (2000) 1317-1325
14. Sherwin B.B. Estrogen and/or androgen replacement therapy in surgical menopausal women. Psychoneuroendocrinology 13 (1988) 345-357
15. Maki P.M., and Resnick S.M. Longitudinal effects of estrogen replacement therapy on PET cerebral blood flow and cognition. Neurobiol Aging 21 (2000) 373-383
16. Barrett-Connor E., and Kritz-Silverstein D. Estrogen replacement therapy and cognitive function in older women. JAMA 269 (1993) 2637-2641
17. Grady D., Herrington D., Bittner V., et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA 288 (2002) 49-57
18. Hays J., Ockene J.K., Brunner R.L., et al. Women's Health Initiative Investigators Effects of estrogen plus progestin on health-related quality of life. N Engl J Med 348 (2003) 1839-1854
19. Sherwin B.B. Estrogen effects on cognition in menopausal women. Neurology 48 (1997) S21-S26
20. Resnick S.M., Metter E.J., and Zonderman A.B. Estrogen replacement therapy and longitudinal decline in visual memory. A possible protective effect?. Neurology 49 (1997) 1491-1497
21. Carlson L.E., and Sherwin B.B. Relationships among cortisol (CRT), dehydroepiandrosterone-sulfate (DHEAS), and memory in a longitudinal study of healthy elderly men and women. Neurobiol Aging 20 (1999) 315-324
22. Maki P.M., and Resnick S.M. Effects of estrogen on patterns of brain activity at rest and during cognitive activity: a review of neuroimaging studies. Neuroimage 14 (2001) 789-801
23. Schmidt R., Fazekas F., Reinhart B., et al. Estrogen replacement therapy in older women: a neuropsychological and brain MRI study. J Am Geriatr Soc 44 (1996) 1307-1313
24. Resnick S.M., Maki P.M., Golski S., Kraut M.A., and Zonderman A.B. Effects of estrogen replacement therapy on PET cerebral blood flow and neuropsychological performance. Horm Behav 34 (1998) 171-182
25. Lezak M.D. Neuropsychological assessment. 3rd ed. (1995), New York Oxford University Press, New York
26. Binetti G., Magni E., Padovani A., Cappa S.F., Bianchetti A., and Trabucchi M. Executive dysfunction in early Alzheimer's disease. J Neurol Neurosurg Psychiatry 60 (1996) 91-93
27. Good C.D., Johnsrude I.S., Ashburner J., Henson R.N., Friston K.J., and Frackowiak R.S. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14 (2001) 21-36
28. Riello R., Sabattoli F., Beltramello A., et al. Brain volumes in healthy adults aged 40 years and over: a voxel based morphometry study. Aging Clin Exp Res 17 (2005) 329-336
29. DeCarli C., Maisog J., Murphy D.G., Teichberg D., Rapoport S.I., and Horwitz B. Method for quantification of brain, ventricular, and subarachnoid CSF volumes from MR images. J Comput Assist Tomogr 16 (1992) 274-284
30. DeCarli C., Murphy D.G., Gillette J.A., et al. Lack of age-related differences in temporal lobe volume of very healthy adults. Am J Neuroradiol 15 (1994) 689-696
31. Pierson R., Corson P.W., Sears L.L., et al. Manual and semiautomated measurement of cerebellar subregions on MR images. Neuroimage 17 (2002) 61-76
32. Harman D. Aging: overview. Ann NY Acad Sci 928 (2001) 1-21
33. Luoto R., Manolio T., Meilahn E., et al. Estrogen replacement therapy and MRI-demonstrated cerebral infarcts, white matter changes, and brain atrophy in older women: the Cardiovascular Health Study. J Am Geriatr Soc 48 (2000) 467-472
34. Matthews K., Cauley J., Yaffe K., and Zmuda J.M. Estrogen replacement therapy and cognitive decline in older community women. J Am Geriatr Soc 47 (1999) 518-523
35. Szklo M., Cerhan J., Diez-Roux A.V., et al. Estrogen replacement therapy and cognitive functioning in the Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 144 (1996) 1048-1057
36. Lee J.Y., Lyoo I.K., Kim S.U., et al. Intellect declines in healthy elderly subjects and cerebellum. Psychiatry Clin Neurosci 59 (2005) 45-51
37. Schmahmann J.D., and Sherman J.C. The cerebellar cognitive affective syndrome. Brain 121 (1998) 561-579
38. Ross S.J., Graham N., Stuart-Green L., et al. Progressive biparietal atrophy: an atypical presentation of Alzheimer's disease. J Neurol Neurosurg Psychiatry 61 (1996) 388-395