Synthesis and primary cytotoxicity evaluation of arylmethylenenaphthofuranones derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 21, Issue 3, 2006, Pages 313-325

  Lardic, Morgane ^a   Patry, Cedric ^a   Duflos, Muriel ^a   Guillon, Jean ^b   Massip, Stephane ^c   Cruzalegui, Francisco ^c   Edmonds, Thomas ^c   Giraudet, Stephanie ^c   Marini, Laetitia ^c   Leonce, Stephane ^c  

^a UNIVERSITÉ DE NANTES   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

2 (arylmethylene)naphtho 2,1 b furan 3(2H) ones; 3 (arylmethylene)naphtho 2,1 b furan 2(3H) ones; Cytotoxicity evaluation; Knoevenagel coupling

Indexed keywords

2 (3,5 DIBROMO 4 HYDROXYBENZYLIDENE)NAPHTHO[2,1 B]FURAN 3(2H) ONE; 2 (4 OXO 1 BENZOPYRAN 3 YLMETHYLENE)NAPHTHO[2,1 B]FURAN 3 ONE; 2 (ARYLMETHYLENE)NAPHTHO[2,1 B]FURAN 3(2H) ONE DERIVATIVE; 2 [(3,5 DIMETHYL 1H PYRROL 2 YL)METHYLENE]NAPHTHO[2,1 B]FURAN 3(2H) ONE; 2,3 DIHYDRONAPHTHO[2,1 B]FURAN 2,3 DIOL; 3 (1H IMIDAZOL 4 YLMETHYLENE)NAPHTHO[2,1 B]FURAN 2(3H) ONE; 3 (3,5 DIBROMO 4 HYDROXYBENZYLIDENE)NAPHTHO[2,1 B]FURAN 2(3H) ONE; 3 (4 OXO 1 BENZOPYRAN 3 YLMETHYLENE)BENZO[B]FURAN 2(3H) ONE; 3 (4 OXO 1 BENZOPYRAN 3 YLMETHYLENE)NAPHTHO[2,1 B]FURAN 2(3H) ONE; 3 (6 CHLORO 4 OXO 1 BENZOPYRAN 3 YLMETHYLENE)NAPHTHO[2,1 B]FURAN 2(3H) ONE; 3 (6 METHYL 4 OXO 1 BENZOPYRAN 3 YLMETHYLENE)NAPHTHO[2,1 B]FURAN 2(3H) ONE; 3 (6 NITRO 4 OXO 1 BENZOPYRAN 3 YLMETHYLENE)NAPHTHO[2,1 B]FURAN 2(3H) ONE; 3 (ARYLMETHYLENE)NAPHTHO[2,1 B]FURAN 2(3H) ONE DERIVATIVE; 3 [(1 METHYL 1H IMIDAZOL 4 YL)METHYLENE]NAPHTHO[2,1 B]FURAN 2(3H) ONE; 3 [(1 METHYL 1H IMIDAZOL 5 YL)METHYLENE]NAPHTHO[2,1 B]FURAN 2(3H) ONE; 3 [(3,5 DIMETHYL 1H PYRROL 2 YL)METHYLENE]NAPHTHO[2,1 B]FURAN 2(3H) ONE; 4 AMINONAPHTHO[2,1 B]FURAN 3(2H) ONE; 5 METHOXYNAPHTHO[2,1 B]FURAN 3(2H) ONE; 8 [(N TERT BUTYLOXYCARBONYL)AMINO]NAPHTH 2 OL; [(7 METHOXYNAPHTH 2 YL)OXY]ACETIC ACID; [8 [( TERT BUTYLOXYCARBONYLAMINO)NAPHTH 2 YL]OXY]ACETIC ACID; ANTINEOPLASTIC AGENT; ARYLMETHYLENENAPHTHOFURANONE DERIVATIVE; BENZO[B]FURAN 2(3H) ONE; CYTOTOXIC AGENT; FURANONE DERIVATIVE; NAPHTHO[2,1 B]FURAN 2(3H) ONE; NAPHTHO[2,1 B]FURAN 3(2H) ONE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; KNOEVENAGEL CONDENSATION; LEUKEMIA L 1210; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZOFURANS; BENZOPYRANS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; FURANS; LEUKEMIA L1210; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHALENES; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746169841     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360600741834     Document Type: Article

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