Persistent hyperparathyroidism in renal allograft recipients: Vitamin D receptor, calcium-sensing receptor, and apoptosis

Kidney International

Volumn 70, Issue 2, 2006, Pages 363-370

  Taniguchi, M ^a   Tokumoto, M ^a   Matsuo, D ^a   Motoyama, K ^a   Sugitani, A ^a   Kuroki, S ^a   Yotsueda, H ^a   Tsuruya, K ^a   Hirakata, H ^b,c   Iida, M ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY HOSPITAL   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Apoptosis; Calciumsensing receptor; Hyperparathyroidism; Renal transplantation; Vitamin D

Indexed keywords

CALCIUM SENSING RECEPTOR; KI 67 ANTIGEN; VITAMIN D RECEPTOR;

ADULT; APOPTOSIS; ARTICLE; CELL HYPERPLASIA; CELL VOLUME; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; GRAFT RECIPIENT; HEMODIALYSIS; HUMAN; HUMAN TISSUE; HYPERPARATHYROIDISM; IMMUNOREACTIVITY; KIDNEY ALLOGRAFT; KIDNEY TRANSPLANTATION; LABELING INDEX; MEASUREMENT; NICK END LABELING; NODULAR HYPERPLASIA; PARATHYROID CELL; PARATHYROID HYPERPLASIA; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR UPREGULATION; REMISSION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; UREMIA;

APOPTOSIS; CALCIUM; HUMANS; HYPERPARATHYROIDISM, SECONDARY; HYPERPLASIA; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KI-67 ANTIGEN; KIDNEY TRANSPLANTATION; MIDDLE AGED; PARATHYROID GLANDS; POSTOPERATIVE COMPLICATIONS; RECEPTORS, CALCITRIOL; RECEPTORS, CALCIUM-SENSING; TRANSPLANTATION, HOMOLOGOUS;

EID: 33746157756     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5001549     Document Type: Article

References (39)

1. Brown AJ, Ritter CS, Finch JL et al. Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: role of dietary phosphate. Kidney Int 1999; 55: 1284-1292.
2. 2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 1996; 81: 1589-1606.
3. Gogusev J, Duchambon P, Hory B et al. Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. Kidney Int 1997; 51: 328-336.
4. 3 in the parathyroid glands of patients with renal failure. N Engl J Med 1987; 316: 1573-1577.
5. 3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients. J Clin Invest 1993; 92: 1436-1443.
6. 3 receptors are decreased in parathyroid glands from chronically uremic dogs. Kidney Int 1989; 35: 19-23.
7. Tokumoto M, Tsuruya K, Fukuda K et al. Reduced p21, p27 and vitamin D receptor in the nodular hyperplasia in patients with advanced secondary hyperparathyroidism. Kidney Int 2002; 62: 1196-1207.
8. WAF1 and transforming growth factor-α mediate dietary phosphate regulation of parathyroid cell growth. Kidney Int 2001; 59: 855-865.
9. WAF1 and TGF-α mediate parathyroid growth arrest by vitamin D and high calcium. Kidney Int 2001; 60: 2109-2117.
10. Alsina J, Gonzalez MT, Bonnin R et al. Long-term evolution of renal osteodystrophy after renal transplantation. Transplant Proc 1989; 21: 2151-2158.
11. Saha HH, Salmela KT, Ahonen PJ et al. Sequential changes in vitamin D and calcium metabolism after successful renal transplantation. Scand J Urol Nephrol 1994; 28: 21-27.
12. Claesson K, Hellman P, Frödin L et al. Prospective study of calcium homeostasis after renal transplantation. World J Surg 1998; 22: 635-642.
13. Bonarek H, Merville P, Bonarek M et al. Reduced parathyroid functional mass after successful kidney transplantation. Kidney Int 1999; 56: 642-649.
14. Messa P, Sindici C, Cannella G et al. Persistent secondary hyperparathyroidism after renal transplantation. Kidney Int 1998; 54: 1704-1713.
15. Schmid T, Muller P, Spelsberg F. Parathyroidectomy after renal transplantation: a retrospective analysis of long-term outcome. Nephrol Dial Transplant 1997; 12: 2393-2396.
16. Mourad M, Malaise J, Chautems RC et al. Early posttransplant calcemia as a predictive indicator for parathyroidectomy in kidney allograft recipients with tertiary hyperparathyroidism. Transplant Proc 2000; 32: 437-440.
17. Kinnaert P, Nagy N, Decoster-Gervy C et al. Persistent hyperparathyroidism requiring surgical treatment after kidney transplantation. World J Surg 2000; 24: 1391-1395.
18. Kligo M, Pirsch JD, Warner TF et al. Tertiary hyperparathyroidism after renal transplantation: surgical strategy. Surgery 1998; 124: 677-684.
19. Kerby JD, Rue LW, Blair H et al. Operative treatment of tertiary hyperparathyroidism. A single-center experience. Ann Surg 1998; 227: 878-886.
20. Christensen MS, Nielsen HE. Parathyroid function after renal transplantation: interrelationships between renal function, serum calcium and serum parathyroid hormone in normocalcemic long-term survivors. Clin Nephrol 1977; 8: 472-476.
21. McCarron DA, Muther RS, Lenfesty B et al. Parathyroid function in persistent hyperparathyroidism: relationship to gland size. Kidney Int 1982; 22: 662-670.
22. Harach HR, Jasani B. Parathyroid hyperplasia in tertiary hyperparathyroidism: a pathological and immunohistochemical reappraisal. Histopathology 1992; 21: 513-519.
23. Lewin E, Wang W, Olgaard K. Reversibility of experimental secondary hyperparathyroidism. Kidney Int 1997; 52: 1232-1241.
24. Wang Q, Palnitkar S, Parfitt AM. Parathyroid cell proliferation in the rat: effect of age and of phosphate administration and recovery. Endocrinology 1996; 137: 4558-4562.
25. Wang Q, Palnitkar S, Parfitt AM. The basal rate of cell proliferation in normal human parathyroid tissue: implications for the pathogenesis of hyperparathyroidism. Clin Endocrinol 1997; 46: 343-349.
26. Drüeke TB. Cell biology of parathyroid gland hyperplasia in chronic renal failure. J Am Soc Nephrol 2000; 11: 1141-1152.
27. Zhang P, Duchambon P, Gogusev J et al. Apoptosis in parathyroid hyperplasia of patients with primary or secondary uremic hyperparathyroidism. Kidney Int 2000; 57: 437-445.
28. Parfitt AM. The hyperparathyroidism of chronic renal failure: a disorder of growth. Kidney Int 1997; 52: 3-9.
29. 3 and 22-oxacalcitriol prevent the decrease in vitamin D receptor content in the parathyroid glands of uremic rats. Kidney Int 1996; 50: 34-39.
30. Brown AJ, Zhong M, Finch J et al. Rat calcium-sensing receptor is regulated by vitamin D but not by calcium. Am J Physiol 1996; 270: F454-F460.
31. Canaff L, Hendy GN. Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D. J Biol Chem 2002; 277: 30337-30350.
32. Nagano N, Miyata S, Abe M et al. Sevelamer hydrochloride reverses parathyroid gland enlargement via regression of cell hypertrophy but not apoptosis in rats with chronic renal insufficiency. Nephrol Dial Transplant 2006; 21: 634-643.
33. Drüeke TB, Zhang P, Gogusev J. Apoptosis: background and possible role in secondary hyperparathyroidism. Nephrol Dial Transplant 1997; 12: 2228-2233.
34. Fukagawa M, Okazaki R, Takano K et al. Regression of parathyroid hyperplasia by calcitriol-pulse therapy in patients on long-term dialysis. N Engl J Med 1990; 323: 421-422.
35. Fukagawa M, Kitaoka M, Yi H et al. Serial evaluation of parathyroid size by ultrasonography is another useful marker for the long-term prognosis of calcitriol pulse therapy in chronic dialysis patients. Nephron 1994; 68: 221-228.
36. 3 in prostate cancer. Mol Cancer Ther 2002; 9: 667-677.
37. Tominaga Y, Tanaka Y, Sato K et al. Histopathology, pathophysiology, and indications for surgical treatment of renal hyperparathyroidism. Semin Surg Oncol 1997; 13: 78-86.
38. Kruse AE, Eisenberger U, Frey FJ et al. The calcimimetic cinacalcet normalizes serum calcium in renal transplant patients with persistent hyperparathyroidism. Nephrol Dial Transplant 2005; 20: 1311-1314.
39. Serra AL, Schwarz AA, Wick FH et al. Successful treatment of hypercalcemia with cinacalcet in renal transplant recipients with persistent hyperparathyroidism. Nephrol Dial Transplant 2005; 20; 1315-1319.