Metallo-β-lactamases;Metalo-β-lactamases

Jornal Brasileiro de Patologia e Medicina Laboratorial

Volumn 42, Issue 2, 2006, Pages 103-113

  Mendes, Rodrigo Elisandro ^a   Castanheira, Mariana ^b   Campos Pignatari, Antonio Carlos ^b   Gales, Ana Cristina ^b  

^a Laboratório Especial de Microbiologia Clínica   (Brazil)

^b NONE

Author keywords

Carbapenem resistance; Gene cassette; Gram negative bacilli; Integron; Metallo lactamase

Indexed keywords

EID: 33746134416     PISSN: 16762444     EISSN: 16784774     Source Type: Journal    
DOI: 10.1590/S1676-24442006000200007     Document Type: Review

References (83)

1. AFZAL-SHAH, M. et al. Characterization of OXA-25, OXA-26, and OXA-27, molecular class D β-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii. Antimicrob Agents Chemother, v. 45, n. 2, p. 583-8, 2001.
2. ARAKAWA, Y. et al. Convenient test for screening metallo-β- lactamase-producing gram-negative bacteria by using thiol compounds. J Clin Microbiol, v. 38, n. 1, p. 40-3, 2000.
3. AVISON, M. B. et al. Plasmid location and molecular heterogeneity of the L1 and L2 β-lactamase genes of Stenotrophomonas maltophilia. Antimicrob Agents Chemother, v. 45, n.2, p. 413-9, 2001.
4. BAHAR, G. et al. Detection of VIM-5 metallo-β-lactamase in a Pseudomonas aeruginosa clinical isolate from Turkey. J Antimicrob Chemother, v. 54, n. 1, p. 282-3, 2004.
5. BENNETT, P. M. Integrons and gene cassettes: a genetic construction kit for bacteria. J Antimicrob Chemother, v. 43, n. 1, p. 1-4, 1999.
6. BOU, G. et al. OXA-24, a novel class D β-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain. Antimicrob Agents Chemother, v. 44, n. 6, p. 1556-61, 2000.
7. BUSH, K. Metallo-β-lactamases: a class apart. Clin Infect Dis, v. 27, suppl. 1, p. S48-S53, 1998.
8. BUSH, K. et al. A functional classification scheme for β-lactamases and its correlation with molecular structure. Antimicrob Agents Chemother, v. 39, n. 6, p. 1211-33, 1995.
9. rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, n. C2-2023, p. 153, 2003.
10. GIM-1, encoding a new subclass of metallo-β-lactamase. Antimicrob Agents Chemother, v. 48, n. 12, p. 4654-61, 2004.
11. CHU, Y. W. et al. IMP-4, a novel metallo-β-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998. Antimicrob Agents Chemother, v. 45, n. 3, p. 710-4, 2001.
12. CLINICAL LABORATORY STANDARDS INSTITUTE. Perfomance standards for antimicrobial susceptibility testing. Fifteenth informational supplement. v. Fifteenth, n. 25, p. 1-172, 2005.
13. COLLIS, C. M. et al. Site-specific insertion of gene cassettes into integrons. Mol Microbiol, v. 9, n. 1, p. 41-52, 1993.
14. COLLIS, C. M.; HALL, R. M. Site-specific deletion and rearrangement of integron insert genes catalyzed by the integron DNA integrase. J Bacteriol, v. 174, n. 5, p. 1574-85, 1992.
15. COLLIS, C. M.; HALL, R. M. Expression of antibiotic resistance genes in the integrated cassettes of integrons. Antimicrob Agents Chemother, v. 39, n. 1, p. 155-62, 1995.
16. COLLIS, C. M. et al. Characterization of the class 3 integron and the site-specific recombination system it determines. J Bacteriol, v. 184, n. 11, p. 3017-26, 2002.
17. COLLIS, C. M. et al. Integron-encoded Intl integrases preferentially recognize the adjacent cognate attl site in recombination with a 59-be site. Mol Microbiol, v. 46, n. 5, p. 1415-27, 2002.
18. CRESPO, M. P. et al. Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-8, a novel metalloβ-lactamase, in a tertiary care center in Cali, Colombia. J Clin Microbiol, v. 42, n. 11, p. 5094-101, 2004.
19. CROWDER, M. W. et al. Overexpression, purification and characterization of the cloned metallo-β-lactamase L1 from Stenotrophomonas maltophilia. Antimicrob Agents Chemother, v. 42, n.4, p. 921-6, 1998.
20. IMP-5, a new integron-borne metallo-β-lactamase gene from an Acinetobacter baumannii nosocomial isolate in Portugal. FEMS Microbiol Lett, v. 215, n. 1, p. 33-9, 2002.
21. DOCQUIER, J. D. et al. IMP-12, a new plasmid-encoded metalloβ- lactamase from a Pseudomonas putida clinical isolate. Antimicrob Agents Chemother, v. 47, n. 5, p. 1522-8, 2003.
22. DONALD, H. M. et al. Sequence analysis of ARI-1, a novel OXA β-lactamase, responsible for imipenem resistance in Acinetobacter baumannii 6B92. Antimicrob Agents Chemother, v. 44, n. 1, p. 196-9, 2000.
23. GALES, A. C. et al. Dissemination in distinct Brazilian regions of an epidemic carbapenem-resistant Pseudomonas aeruginosa producing SPM metallo-β-lactamase. J Antimicrob Chemother, v. 52, n. 4, p. 699-702, 2003.
24. GALES, A. C. et al. Emergence of an IMP-like metallo-enzyme in an Acinetobacter baumannii clinical strain from a Brazilian teaching hospital. Diagn Microbiol Infect Dis, v. 45, n. 1, p. 77-9, 2003.
25. IMP-7. Antimicrob Agents Chemother, v. 46, n. 1, p. 255-8, 2002.
26. th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, n. C2-1355, p. 112, 2004.
27. HERITIER, C. et al. Genetic and functional analysis of the chromosome-encoded carbapenem-hydrolyzing oxacillinase OXA-40 of Acinetobacter baumannii. Antimicrob Agents Chemother, v. 47, n. 1, p. 268-73, 2003.
28. IYOBE, S. et al. Amino acid substitutions in a variant of IMP-1 metallo-β-lactamase. Antimicrob Agents Chemother, v. 44, n. 8, p. 2023-7, 2000.
29. IYOBE, S. et al. Detection of a variant metallo-β-lactamase, IMP-10, from two unrelated strains of Pseudomonas aeruginosa and an Alcaligenes xylosoxidans strain. Antimicrob Agents Chemother, v. 46, n. 6, p. 2014-6, 2002.
30. KOH, T. H. et al. IMP-1 and a novel metallo-β-lactamase, VIM-6, in fluorescent pseudomonads isolated in Singapore. Antimicrob Agents Chemother, v. 48, n. 6, p. 2334-6, 2004.
31. LARAKI, N. et al. Biochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-β-lactamase IMP-1 produced by Escherichia coli. Antimicrob Agents Chemother, v. 43, n. 4, p. 902-6, 1999.
32. LARTIGUE, M. F. et al. First detection of a carbapenem-hydrolyzing metalloenzyme in an Enterobacteriaceae isolate in France. Antimicrob Agents Chemother, v. 48, n. 12, p. 4929-30, 2004.
33. VIM, a new integron-borne metallo-β-lactamase gene from a Pseudomonas aeruginosa clinical isolate. Antimicrob Agents Chemother, v. 43, n. 7, p. 1584-90, 1999.
34. LEE, K. et al. Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-β-lactamase-producing isolates of Pseudomonas spp. and Acinetobacter spp. J Clin Microbiol, v. 41, n. 10, p. 4623-9, 2003.
35. SIM-1, in a class I integron from Acinetobacter baumannii clinical isolates from Korea. Antimicrob Agents Chemother, v. 49, n. 11, p. 4485-91, 2005.
36. LINCOPAN, N. et al. First isolation of metallo-β-lactamase-producing multiresistant Klebsiella pneumoniae from a patient in Brazil. J Clin Microbiol, v. 43, n. 1, p. 516-9, 2005.
37. LIVERMORE, D. M. Of Pseudomonas, porins, pumps and carbapenems. J Antimicrob Chemother, v. 47, n. 3, p. 247-50, 2001.
38. LIVERMORE, D. M. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: Our worst nightmare? Clin Infect Dis, v. 34, n. 5, p. 634-40, 2002.
39. MASSIDDA, O. et al. The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-β-lactamases. J Bacteriol, v. 173, n. 15, p. 4611-7, 1991.
40. MENDES, R. E. Caracterização dos elementos móveis responsáveis pela disseminação de genes associados à resistênda bacteriana em Pseudomonas spp. isoladas na América Latina. 2005. Tese (doutoramento) - Disciplina de Infectologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo.
41. VIM-2 in Latin America: report from the SENTRY Antimicrobial Surveillance Program. Antimicrob Agents Chemother, v. 48, n. 4, p. 1433-4, 2004.
42. th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, n. C1-298, p. 66, 2004.
43. IMP-16 and a Fused form of aminoglycoside-resistant gene aac(6′)-30/aac(6′)-lb′: report from the SENTRY Antimicrobial Surveillance Program. Antimicrob Agents Chemother, v. 48, n. 12, p. 4693-702, 2004.
44. MURPHY,T.A. et al. Biochemical characterization of the acquired metallo-β-lactamase SPM-1 from Pseudomonas aeruginosa. Antimicrob Agents Chemother, v. 47, n. 2, p. 582-7, 2003.
45. th ed. 2003. n. 20.
46. OSANO, E. et al. Molecular characterization of an enterobacterial metallo-β-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance. Antimicrob Agents Chemother, v. 38, n. 1, p. 71-8, 1994.
47. PARTRIDGE, S. R. et al. Characterization and movement of the class I integron known as Tn252l and Tnl405. Antimicrob Agents Chemother, v. 46, n. 5, p. 1288-94, 2002.
48. PARTRIDGE, S. R. et al. Definition of the attll site of class I integrons. Microbiology, v. 146 (Pt 11), p. 2855-64, 2000.
49. VIM family in a GES-1 extended-spectrum-β-lactamase-producing Pseudomonas aeruginosa clinical isolate in Argentina. Antimicrob Agents Chemother, v. 49, n. 1, p. 474-5, 2005.
50. VIM-4 gene cassette isolated from hospitalized children in Poland (1998-2001). J Antimicrob Chemother, v. 53, n. 3, p. 451-6, 2004.
51. PELLEGRINO, F. L. et al. Occurrence of a multidrug-resistant Pseudomonas aeruginosa clone in different hospitals in Rio de Janeiro, Brazil. J Clin Microbiol, v. 40, n. 7, p. 2420-4, 2002.
52. VIM-2 carbapenem-hydrolyzing β-lactamase gene and of two novel aminoglycoside resistance gene cassettes. Antimicrob Agents Chemother, v. 45, n. 2, p. 546-52, 2001.
53. SPM-1-surrounding sequences from disseminated Pseudomonas aeruginosa isolates in Recife, Brazil. Antimicrob Agents Chemother, v. 48, n. 4, p. 1406-9, 2004.
54. POIREL, L. et al. OXA-58, a novel class D β-lactamase involved in resistance to carbapenems in Acinetobacter baumannii. Antimicrob Agents Chemother, v. 49, n. 1, p. 202-8, 2005.
55. POIREL, L. et al. Characterization of VIM-2, a carbapenem-hydrolyzing metallo-β-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France. Antimicrob Agents Chemother, v. 44, n. 4, p. 891 7, 2000.
56. POIREL, L.; NORDMANN, P.Acquired carbapenem-hydrolyzing β-lactamases and their genetic support. Curr Pharm Biotechnol, v. 3, n. 2, p. 117-27, 2002.
57. VIM-1, in a clinical strain of Pseudomonas aeruginosa. Antimicrob Agents Chemother, v. 46, n. 12, p. 4026-8, 2002.
58. PRATS, G. et al. First isolation of a carbapenem-hydrolyzing β-lactamase in Pseudomonas aeruginosa in Spain. Antimicrob Agents Chemother, v. 46, n. 3, p. 932-3, 2002.
59. QUINTEIRA, S. et al. Characterization of In100, a new integron carrying a metallo-β-lactamase and a carbenicillinase, from Pseudomonas aeruginosa. Antimicrob Agents Chemother, v. 49, n. 1, p. 451-3, 2005.
60. RECCHIA, G. D.; HALL, R. M. Origins of the mobile gene cassettes found in integrons. Trends Microbiol, v. 5, n. 10, p. 389-94, 1997.
61. IMP allelic variants carried by gene cassettes of different phylogeny. Antimicrob Agents Chemother, v. 44, n. 5, p. 1229-35, 2000.
62. RICCIO, M. L. et al. Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo-β-lactamase from different Italian hospitals. Antimicrob Agents Chemother, v. 49, n. 1, p. 104-10, 2005.
63. ROSSOLINI, G. M. et al. Characterization and sequence of the Chryseobacterium (Flavobacterium) meningosepticum carbapenemase: a new molecular class B β-lactamase showing a broad substrate profile. Biochem J, v. 332 (Pt 1), p. 145-52, 1998.
64. SIMM, A. M. et al. A novel metallo-β-lactamase, MbIIb, produced by the environmental bacterium Caulobacter crescentus. FEBS Lett, v. 509, n. 3, p. 350-4, 2001.
65. SPENCER, J. et al. Novel mechanism of hydrolysis of therapeutic β-lactams by Stenotrophomonas maltophilia L1 metallo-β-lactamase. J Biol Chem, v. 276, n. 36, p. 33638-44, 2001.
66. STOKES, H.W.; HALL, R. M. A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: integrons. Mol Microbiol, v. 3, n. 12, p. 1669-83, 1989.
67. THOMPSON, J. S.; MALAMY M. H. Sequencing the gene for an imipenem-cefoxitin-hydrolyzing enzyme (CfiA) from Bacteroides fragilis TAL2480 reveals strong similarity between CfiA and Bacillus cereus β-lactamase II. J Bacteriol, v. 172, n. 5, p. 2584-93, 1990.
68. TOGNIM, M. C. Dissemination of IMP-1 metallo-β-lactamase-producing Acinetobacter species in a Brazilian teaching hospital. Infect Control Hosp Epidemiol, 2006. In press.
69. IMP-13, harboured by a novel Tn505l-type transposon disseminating carbapenemase genes in Europe: report from the SENTRY Antimicrobial Surveillance Program. J Antimicrob Chemother, v. 52, n. 4, p. 583-90, 2003.
70. TOLEMAN, M. A. et al. Italian metallo-β-lactamases: a national problem? Report from the SENTRY Antimicrobial Surveillance Program. J Antimicrob Chemother, v. 55, n. 1, p. 61-70, 2005.
71. VIM-7, an evolutionarily distinct metallo-β-lactamase gene in a Pseudomonas aeruginosa isolate from the United States. Antimicrob Agents Chemother, v. 48, n. 1, p. 329-32, 2004.
72. TOLEMAN, M. A et al. Molecular characterization of SPM-1, a novel metallo-β-lactamase isolated in Latin America: report from the SENTRY Antimicrobial Surveillance Program. J Antimicrob Chemother, v. 50, n. 5, p. 673-9, 2002.
73. URBAN, C. et al. Considerations in control and treatment of nosocomial infections due to multidrug-resistant Acinetobacter baumannii. Clin Infect Dis, v. 36, n. 10, p. 1268-74, 2003.
74. WALSH, T. R. et al. Evaluation of a new Etest for detecting metallo-β-lactamases in routine clinical testing. J Clin Microbiol, v. 40, n. 8, p. 2755-9, 2002.
75. WALSH, T. R. et al. Enzyme kinetics and biochemical analysis of ImiS, the metallo-β-lactamase from Aeromonas sobria 163a. J Antimicrob Chemother, v. 37, n. 3, p. 423-31, 1996.
76. WALSH, T. R. et al. Nucleotide and amino acid sequences of the 7metallo-β-lactamase, ImiS, from Aeromonas veronii bv. sobria. Antimicrob Agents Chemother, v. 42, n. 2, p. 436-9, 1998.
77. VIM-2 in Eastern Europe: report from the SENTRY Antimicrobial Surveillance Program. J Antimicrob Chemother, v. 52, n. 1, p. 116-9, 2003.
78. B3, in the type strain, NCTC 10016. Antimicrob Agents Chemother, v. 44, n. 6, p. 1448-52, 2000.
79. YAN, J. J. et al. Metallo-β-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme. Antimicrob Agents Chemother, v. 45, n. 8, p. 2224-8, 2001.
80. YAN, J. J. et al. Identification of a plasmid encoding SHV-12, TEM-1 and a variant of IMP-2 metallo-β-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae. Antimicrob Agents Chemother, v. 45, n. 8, p. 2368-71, 2001.
81. YAN, J. J. et al. Comparison of the double-disk, combined disk and Etest methods for detecting metallo-β-lactamases in gram-negative bacilli. Diagn Microbiol Infect Dis, v. 49, n. 1, p. 5-11, 2004.
82. YANO, H. et al. Plasmid-encoded metallo-β-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem. Antimicrob Agents Chemother, v. 45, n. 5, p. 1343-8, 2001.
83. VIM-2 gene cassettes. J Antimicrob Chemother, v. 49, n. 5, p. 837-40, 2002.