C19-Steroids as androgen receptor modulators: Design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 17, 2006, Pages 5933-5947

  Marwah, Padma ^a   Marwah, Ashok ^a   Lardy, Henry A ^a   Miyamoto, Hiroshi ^b   Chang, Chawnshang ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Adiol; Androgen receptor; Androstadienes; Antiandrogens; C19 Steroids

Indexed keywords

17ALPHA ETHYNYLANDROST 5 ENE 3BETA,17BETA DIOL; 17BETA ACETOXYANDROST 4 ENE 3,6 DIONE; 17BETA PROPIONYLLOXYANDROST 5 ENE 3,7 DIONE 3 ETHYLENE KETAL; 3BETA ACETOXYANDROSTA 1,5 DIEN 17 ONE; 3BETA ACETOXYANDROSTA 1,5 DIEN 17BETA OL; 3BETA ACETOXYANDROSTA 1,5 DIENE 17 ONE 17 ETHYLENE KETAL; 3BETA HYDROXYANDROSTA 1,5 DIEN 17 ONE; 3BETA HYDROXYANDROSTA 5,16 DIENE; 3BETA,16ALPHA DICARBOMETHOXYANDROST 5 EN 17 ONE; 3BETA,16ALPHA DICARBOMETHOXYANDROST 5 ENE 7,17 DIONE; 3BETA,16BETA DIACETOXYANDROST 5 EN 17 ONE; 3BETA,17BETA DIACETOXY 17ALPHA ETHYNYLANDROSTA 1,5 DIENE; 3BETA,17BETA DIHYDROANDROST 5 EN 7 ONE; 3BETA,17BETA DIHYDROXY 17ALPHA ETHYNYLANDROSTA 1,5 DIENE; 3BETA,17BETA DIHYDROXYANDROST 5 EN 16 ONE; 7ALPHA HYDROXYANDROST 5 ENE 3,17 DIONE 3,17 DIETHYLENE DIKETAL; ANDROGEN RECEPTOR; ANDROGEN RECEPTOR ANTAGONIST; ANDROST 5 ENE 3,17 DIONE 3,17 DIETHYLENE DIKETAL; ANDROST 5 ENE 3BETA,7ALPHA,17BETA TRIOL; ANDROST 5 ENE 3BETA,7BETA,17BETA TRIOL; ANDROSTA 1,4 DIENE 3,17 DIONE 17 ETHYLENE KETAL; ANDROSTANEDIOL; ANDROSTANOLONE; ANDROSTENEDIOL; PRASTERONE; PROSTATE SPECIFIC ANTIGEN; RECEPTOR BLOCKING AGENT; STEROID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL STRAIN LNCAP; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSCRIPTION; ISOLATION AND PURIFICATION; METABOLISM; TUMOR CELL LINE;

CELL LINE, TUMOR; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, ANDROGEN; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 33746042152     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.05.022     Document Type: Article

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