A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat

Toxicology and Applied Pharmacology

Volumn 214, Issue 3, 2006, Pages 253-262

  Finch, John M ^a   Osimitz, Thomas G ^b   Gabriel, Karl L ^c   Martin, Tom ^a   Henderson, Wendy J ^a   Capen, Charles C ^d   Butler, William H ^e   Lake, Brian G ^f,g  

^a Inveresk Research   (United Kingdom)

^b Science Strategies LLC   (United States)

^c ConTox Ltd ^*  (United States)

^d OHIO STATE UNIVERSITY   (United States)

^e Glebe Cottage   (United Kingdom)

^f BIBRA INTERNATIONAL   (United Kingdom)

^g UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Cell proliferation; Mode of action; Non genotoxic carcinogens; Pyrethrins; Rat thyroid gland tumors; Sodium phenobarbital; Sprague Dawley rats; Thyroid hormones

Indexed keywords

GLUCURONOSYLTRANSFERASE; LIOTHYRONINE; PHENOBARBITAL; PYRETHROID; THYROID HORMONE; THYROXINE;

ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; CELL HYPERPLASIA; CONTROLLED STUDY; DIET; DNA SYNTHESIS; ENZYME ACTIVITY; FEMALE; HORMONE DETERMINATION; LIOTHYRONINE BLOOD LEVEL; MALE; NONHUMAN; RAT; THYROID FOLLICLE CELL; THYROID GLAND; THYROID TUMOR; THYROID WEIGHT; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; XENOBIOTIC METABOLISM;

ADMINISTRATION, ORAL; ANIMALS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCURONOSYLTRANSFERASE; INSECTICIDES; MALE; MICROSOMES, LIVER; ORGAN SIZE; PHENOBARBITAL; PYRETHRINS; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; THYROID GLAND; THYROID HORMONES; THYROID NEOPLASMS;

EID: 33746010561     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.01.009     Document Type: Article

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