Cytoprotective effect of two synthetic enhancer substances, (-)-BPAP and (-)-deprenyl, on human brain capillary endothelial cells and rat PC12 cells

Life Sciences

Volumn 79, Issue 11, 2006, Pages 1034-1039

  Denes, Laszlo ^a,b   Szilágyi, Géza ^a,b   Gál, Anikó ^a,b   Bori, Zoltán ^a,b   Nagy, Zoltán ^a,b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b NATIONAL INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Hungary)

Author keywords

( ) BPAP; ( ) Deprenyl; Alamar Blue assay; Cytoprotection; Enhancer substances; Human brain endothelial cells (HBEC); Hypoxia reoxygenation; PC12; Propidiumiodide staining

Indexed keywords

1 (BENZOFURAN 2 YL) 2 PROPYLAMINOPENTANE; ARGON; NEUROPROTECTIVE AGENT; PROPIDIUM IODIDE; SELEGILINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BRAIN CAPILLARY; CAPILLARY ENDOTHELIUM; CELL ACTIVITY; CELL LOSS; CELL PROTECTION; COLORIMETRY; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOHISTOCHEMISTRY; NONHUMAN; RAT; REOXYGENATION;

ANIMALS; ANOXIA; BENZOFURANS; BRAIN; CAPILLARIES; CELLS, CULTURED; CYTOPROTECTION; ENDOTHELIAL CELLS; HUMANS; NEUROPROTECTIVE AGENTS; OXIDATION-REDUCTION; PC12 CELLS; RATS; SELEGILINE;

EID: 33745975428     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.03.005     Document Type: Article

References (16)

1. Hamabe W., Fujita R., Yasusa T., Yoneda F., Yoshida A., and Ueda H. (-)-1-(Benzofuran-2-yl)-2-propylaminopentane shows survival effect on cortical neurons under serum-free condition through sigma receptor. Cellular and Molecular Neurobiology 20 6 (2000) 695-702
2. Knoll J. Memories of my 45 years in research. Pharmacology and Toxicology 75 2 (1994) 65-72
3. Knoll J. Enhancer regulation/endogenous and synthetic enhancer compounds: a neurochemical concept of the innate and acquired drives. Neurochemical Research 28 8 (2003) 1275-1297
4. Knoll J. The Brain and Its Self. A Neurochemical Concept of the Innate and Acquired Drives (2005), Springer, Berlin 1-176
5. Knoll J., and Magyar K. Some puzzling pharmacological effects of monoamine oxidase inhibitors. Advances in Biochemistry and Psychopharmacology 5 (1972) 393-408
6. Knoll J., Yoneda F., Knoll B., Ohde H., and Miklya I. (-)-1-(Benzfuran-2yl)-2-propylaminopentane, [(-)-BPAP], a selective enhancer of the impulse propagation mediated release of catecholamine and serotonin in the brain. British Journal of Pharmacology 128 8 (1999) 1723-1732
7. Knoll J., Miklya I., and Knoll B. Stimulation of the catecholaminergic and serotonergic neurons in the rat brain by R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, (-)-BPAP. Life Sciences 71 18 (2002) 2137-2144
8. Löffler M. Restimulation of cell cycle progression by hypoxic tumour cells with deoxynucleosides requires ppm oxygen tension. Experimental Cell Research 169 1 (1987) 255-262
9. Magyar K., and Szende B. (-)-Deprenyl, a selective MAO-B inhibitor, with apoptotic and anti-apoptotic properties. Neurotoxicology 25 1-2 (2004) 233-242
10. Maruyama W., Yi H., Takahashi T., Shimazu S., Ohde H., Yoneda F., Iwasa K., and Naoi M. Neuroprotective function of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R) salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells. Life Sciences 75 1 (2004) 107-117
11. Nagy Z., Vastag M., Skopal J., Kolev K., Machovich R., Kramer J., Karadi I., and Toth M. Human brain microvessel endothelial cell culture as a model system to study vascular factors of ischemic brain. Keio Journal of Medicine 45 3 (1996) 200-206
12. Ohta K., Ohta M., Mizuta I., Fujinami A., Shimazu S., Sato N., Yoneda F., Hayashi K., and Kuno S. Novel catecholaminergic and serotonergic activity enhancer R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane up-regulates neurotic factor synthesis in mouse astrocytes. Neuroscience Letter 328 3 (2002) 205-208
13. Seccombe J.F., and Schaff H.V. Vasoactive factors produced by the endothelium. Physiology and Surgical Implications (1994), Medical Intelligence Unit, R.G. Landes Company, Austin 4-26 Chapter 2
14. Shimazu S., Tanigawa A., Sato N., Yoneda F., Hayashi K., and Knoll J. Enhancer substances: Selegiline and R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane [(-)-BPAP] enhance the neurotrophic factor synthesis on cultured mouse astrocytes. Life Sciences 72 24 (2003) 2785-2792
15. Simon L., Szilágyi G., Bori Z., Orbay P., and Nagy Z. (-)-Deprenyl attenuates apoptosis in experimental brain ischemia. European Journal of Pharmacology 430 2-3 (2001) 235-241
16. Tatton W.G., Ju W.Y.L., Holland D.P., Tai C.E., and Kwan M.M. (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis. Journal of Neurochemistry 63 4 (1994) 1572-1574