Proapoptotic function of FHIT gene

Chinese Journal of Cancer Research

Volumn 18, Issue 2, 2006, Pages 154-160

  Qiu, Zhe Fu ^a   Han, De Min ^a   Zhang, Luo ^a   Zhang, Wei ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Fragile histidine triad (FHIT) gene; Tumor suppressor gene; Tumorigenesis

Indexed keywords

FRAGILE HISTIDINE TRIAD PROTEIN; PROTEIN P53;

APOPTOSIS; CARCINOGENESIS; CELL CYCLE; CELL GROWTH; CELL LOSS; GENETIC TRANSFECTION; HOMEOSTASIS; HUMAN; REVIEW; TUMOR SUPPRESSOR GENE;

EID: 33745931371     PISSN: 10009604     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11670-006-0154-2     Document Type: Review

References (30)

1. Ohta M, Inoue H, Cotticelli MG, et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal cell carcinoma-associated t(3;8) breakpoint is abnormal in digestive tract cancers[J]. Cell 1996; 84: 587-97.
2. Sozzi G, Pastorino U, Moiraghi L, et al. Loss of FHIT function in lung cancer and preinvasive bronchial lesions[J]. Cancer Res 1998; 58:5032-7.
3. Mori M, Mimori K, Shiraishi T, et al. Altered expression of FHIT in carcinoma and precarcinomatous lesions of the esophagus[J]. Cancer Res 2000; 60:1177-82.
4. Baffa R, Gomella LG, Vecchione A, et al. Loss of FHIT expression in transitional cell carcinoma of the urinary bladder[J]. Am J Pathol 2000; 156:419-24.
5. Connolly DC, Greenspan DL, Wu R, et al. Loss of FHIT expression in invasive cervical carcinomas and intraepithelial lesions associated with invasive disease[J]. Clin Cancer Res 2000; 6:3505-10.
6. van Heerden WF, Swart TJ, van Heerden MB, et al. Immunohistochemical evaluation of Fhit protein expression in oral squamous cell carcinomas[J]. J Oral Pathol Med 1999; 28:433-7.
7. Huebner K, Hadaczek P, Siprashvili Z, et al. The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B[J]. Biochim Biophys Acta 1997; 1332: M65-M70.
8. Lebeau MM, Drabkin H, Glover TW, et al. An FHIT tumor suppressor gene[J]. Genes Chromosomes Cancer 1998; 21: 281-9.
9. Mao L. Tumor suppressor genes: does FHIT fit[J]? J Natl Cancer Inst 1998; 90: 412-4.
10. Otterson GA, Xiao GH, Geradts J, et al. Protein expression and functional analysis of the FHIT gene in human tumor cells[J]. J Natl Cancer Inst 1998; 90: 426-32.
11. Guo Z, Vishwanatha JK. Effect of regulated expression of the fragile histidine triad gene on cell cycle and proliferation[J]. Mol Cell Biochem 2000; 204:83-8.
12. Bell JE, Maines MD. Kinetic properties and regulation of biliverdin reductase[J]. Arch Biochem Biophys 1988; 263:1-9.
13. Nan KJ, Ruan ZhP, Jing Zh, et al. Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell proliferation and apoptosis[J], World J Gastroenterol 2005; 11:228-31.
14. Tomizawa Y, Nakajima T, Kohno T, et al. Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma[J]. Cancer Res 1998; 58:5478-83.
15. Capuzzi D, Santoro E, Hauck WW, et al. FHIT expression in gastric adenocarcinoma: correlation with disease stage and survival[J]. Cancer 2000; 88: 24-34.
16. Ji L, Fang BL, Yen N, et al. Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine trial (FHIT) geneoverexpression[J]. Cancer Res 1999; 59: 3333-9.
17. Roz L, Andriani F, Ferreira CG, et al. The apoptotic pathway triggered by the Fhit protein in lung cancer cell lines is not affected by Bcl-2 or Bcl-x(L) overexpression[J]. Oncogene 2004; 23: 9102-10.
18. Roz L, Gramegna M, Ishii H, et al. Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines[J]. Proc Natl Acad Sci USA. 2002; 99: 3615-20.
19. Nishizaki M, Sasaki J, Fang B, et al. Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells[J]. Cancer Res 2004; 64:5745-52.
20. Kristoffel R, Dumon KR, Ishii H, et al. Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer[J]. Cancer Res 2001; 61, 4827-36.
21. Ishii H, Dumon KR, Vecchione A, et al. Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells[J]. Cancer Res 2001; 61: 1578-84.
22. Ishii H, Zanesi N, Vecchione A, et al. Regression of upper gastric cancer in mice by FHIT gene delivery[J]. FASEB J 2003; 17:1768-70.
23. Laura S, Paola A, Silvana T, et al. The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control[J]. Proc Natl Acad Sci USA 1999; 96: 8489-92.
24. Toledo G, Sola JJ, Lozano MD, et al. Loss of FHIT protein expression is related to high proliferation, low apoptosis and worse prognosis in non-small-cell lung cancer[J]. Mod Pathol 2004; 17:440-8.
25. Mady HH, Meinem MF. FHIT protein expression and its relation to apoptosis, tumor histologic grade and prognosis in colorectal adenocarcinoma: an immunohistochemical and image analysis study [J]. Clin Exp Metastasis 2002; 19:351-8.
26. Kitamura A, Yashima K, Okamoto E, et al. Reduced FHIT expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis[J]. Oncology 2001; 61:205-11.
27. Pavelic K, Krizanac S, Cacev T, et al. Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas[J]. Mol Med 2001; 7:442-53.
28. Gopalakrishnan VK, Banerjee AG, Vishwanatha JK. Effect of FHIT gene replacement on growth, cell cycle and apoptosis in pancreatic cancer Cells[J]. Pancreatology 2003; 3:293-302.
29. Cavazzoni A, Petronini PG, Galetti M, et al. Dose-dependent effect of FHIT-inducible expression in Calu-1 lung cancer cell line[J]. Oncogene 2004; 23:8439-46.
30. Sevignani C, Calin GA, Cesari R, et al. Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines[J]. Cancer Res 2003; 63:1183-7.