Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells

Cancer Research

Volumn 61, Issue 4, 2001, Pages 1578-1584

  Ishii, Hideshi ^a   Dumon, Kristoffel R ^a   Vecchione, Andrea ^a   Trapasso, Francesco ^a   Mimori, Koshi ^a,b   Alder, Hansjuerg ^a   Mori, Masaki ^b   Sozzi, Gabriella ^c   Baffa, Raffaele ^a   Huebner, Kay ^a   Croce, Carlo M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FRAGILE HISTIDINE TRIAD PROTEIN;

ADENOVIRUS; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE S PHASE; CHROMOSOME 3P; ESOPHAGUS CANCER; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FAMILY; TRANSGENE; TUMOR SUPPRESSOR GENE;

ACID ANHYDRIDE HYDROLASES; ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELL CYCLE; CELL DIVISION; ESOPHAGEAL NEOPLASMS; GENE THERAPY; GENES, TUMOR SUPPRESSOR; GENETIC VECTORS; HELA CELLS; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM PROTEINS; PROTEIN BIOSYNTHESIS; PROTEINS; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035866368     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes
2. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
3. The role of the FHIT/FRA3B locus in cancer
4. FHIT in human cancer
5. The histidine triad superfamily of nueleotide-binding proteins
6. Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene
7. FHIT mutations in human primary gastric cancer
8. Aberrant FHIT transcripts in squamous cell carcinoma of the uterine cervix
9. FHIT alterations in cancerous and non-cancerous cervical epithelium
10. Methylation of the 5′ CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas
11. Sequence of the FRA3B common fragile region: Implications for the mechanism of FHIT deletion
12. Cancer-specific chromosome alterations in the constitutive fragile region FRA3B
13. Increasing incidence of both major histological types of esophageal carcinomas among men in Sweden
14. Esophageal cancer
15. INK4
16. Study of irradiation effects on cytokine secretion from retrovirally-transduced tumor cells: A model for tumor vaccination
17. Antitumor response of genetically engineered IL-2 expression to human esophageal carcinoma cells in mature T cell-defective condition
18. Frequent expression of midkine gene in esophageal cancer suggests a potential usage of its promoter for suicide gene therapy
19. Differential efficacy of suicide gene therapy by herpes simplex virus-thymidine kinase gene reflects the status of p53 gene in human esophageal cancer cells
20. Frequent deletions of FHIT and FRA3B in Barret's metaplasia and esophageal adenocarcinomas
21. Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus
22. Replacement of Fhit in cancer cells suppresses tumorigenicity
23. The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control
24. Differential susceptibility of renal carcinoma cell lines to tumor suppression by exogenous Fhit expression
25. Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression
26. Protein expression and functional analysis of the FHIT gene in human tumor cells
27. Restored expression of fragile histidine triad protein and tumorigenicity of cervical carcinoma cells
28. Scale-up of the adenovirus expression system for the production of recombinant protein in human 293S cells
29. Flow cytometric methods of analyzing apoptotic cells
30. Loss of FHIT expression in transitional cell carcinoma of the urinary bladder
31. Caspases induce cytochrome c release from mitochondria by activating cytosolic factors
32. The pro-apoptotic proteins. Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol
33. Dysregulation of apoptosis in cancer
34. Molecular and cellular features of esophageal cancer cells
35. Nitrilase, and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans
36. Mitochondria at the crossroad of apoptotic cell death
37. Muir-Torre-like syndrome in Fhit-deficient mice