It is AMPA receptor, not kainate receptor, that contributes to the NBQX-induced antinociception in the spinal cord of rats

Brain Research

Volumn 1100, Issue 1, 2006, Pages 73-77

  Kong, Ling Ling ^a   Yu, Long Chuan ^a  

^a Peking University   (China)

Author keywords

AMPA receptor; Antinociception; Concanavalin A; Diazoxide; Intrathecal injection; Kainate receptor

Indexed keywords

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; CONCANAVALIN A; DIAZOXIDE; KAINIC ACID RECEPTOR; POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; HINDLIMB; LATENT PERIOD; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SPINAL CORD; WITHDRAWAL REFLEX;

ANALGESICS; ANIMALS; CONCANAVALIN A; DIAZOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; INJECTIONS, SPINAL; MALE; PAIN MEASUREMENT; POTASSIUM CHANNELS; QUINOXALINES; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; SPINAL CORD;

EID: 33745924150     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.05.015     Document Type: Article

References (24)

1. Bennett A.D., Everhart A.W., and Hulsebosch C.E. Intrathecal administration of an NMDA or a non-NMDA receptor antagonist reduces mechanical but not thermal allodynia in a rodent model of chronic central pain after spinal cord injury. Brain Res. 859 (2000) 72-82
2. Bredt D.S., and Nicoll R.A. AMPA receptor trafficking at excitatory synapses. Neuron 40 (2003) 361-379
3. Bowie D., Garcia E.P., Marshall J., Traynelis S.F., and Lange G.D. Allosteric regulation and spatial distribution of kainate receptors bound to ancillary proteins. J. Physiol. 547 (2003) 373-385
4. Bureau I., Bischoff S., Heinemann S.F., and Mulle C. Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice. J. Neurosci. 19 (1999) 653-663
5. Dickenson A.H., Chapman V., and Green G.M. The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord. Gen. Pharmacol. 28 (1997) 633-638
6. Engelman H.S., Allen T.B., and MacDermott A.B. The distribution of neurons expressing calcium-permeable AMPA receptors in the superficial lamina of the spinal cord dorsal horn. J. Neurosci. 19 (1999) 2081-2089
7. Engelman H.S., Anderson R.L., Daniele C., and Macdermott A.B. Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate release of inhibitory amino acids in rat spinal cord dorsal horn. Neuroscience 139 (2006) 539-553
8. Fay A.M., and Bowie D. Concanavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptor. J. Physiol. 572 (2006) 201-213
9. Lee C.J., Bardoni R., Tong C.K., Engelman H.S., Joseph D.J., Magherini P.C., and MacDermott A.B. Functional expression of AMPA receptors on central terminals of rat dorsal root ganglion neurons and presynaptic inhibition of glutamate release. Neuron 35 (2002) 135-146
10. Lerma J., Paternain A.V., Rodriguez-Moreno A., and López-García J.C. Molecular physiology of kainate receptors. Physiol. Rev. 81 (2001) 971-998
11. Li P., Wilding T.J., Kim S.J., Calejesan A.A., Huettner J.E., and Zhuo M. Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord. Nature 397 (1999) 161-164
12. Li J.J., Zhou X., and Yu L.C. Involvement of neuropeptide Y and Y1 receptor in antinociception in the arcuate nucleus of hypothalamus, an immunohistochemical and pharmacological study in intact rats and rats with inflammation. Pain 118 (2005) 232-242
13. Liang H.W., Xia Q., and Bruce I.C. Reactive oxygen species mediate the neuroprotection conferred by a mitochondrial ATP-sensitive potassium channel opener during ischemia in the rat hippocampal slice. Brain Res. 1042 (2005) 169-175
14. Lu C.R., Hwang S.J., Phend K.D., Rustioni A., and Valtschanoff J.G. Primary afferent terminals in spinal cord express presynaptic AMPA receptors. J. Neurosci. 22 (2002) 9522-9529
15. Lutfy K., Cai S.X., Woodward R.M., and Weber E. Antinociceptive effects of NMDA and non-NMDA receptor antagonists in the tail flick test in mice. Pain 70 (1997) 31-40
16. Nagy G.G., Al-Ayyan M., Andrew D., Fukaya M., Watanabe M., and Todd A.J. Widespread expression of the AMPA Receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen-unmasking method. J. Neurosci. 24 (2004) 5766-5777
17. Palmer A.J., and Lodge D. Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655. Eur. J. Pharmacol. 244 (1993) 193-194
18. Partin K.M., Patneau D.K., Winters C.A., Mayer M.L., and Buonanno A. Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron 11 (1993) 1069-1082
19. Ruscheweyh R., and Sandkühler J. Role of kainate receptors in nociception. Brain Res. Rev. 40 (2002) 215-222
20. Wilding T.J., and Huettner J.E. Antagonist pharmacology of kainate- and a-amino-3hydroxy-5-methyl-4-isoxazolepropio-nic acid-preferring receptors. Mol. Pharmacol. 49 (1996) 540-546
21. Wu D.C., Zhou N., and Yu L.C. Anti-nociceptive effect induced by intrathecal injection of ATPA, an effect enhanced and prolonged by concanavalin A. Brain Res. 959 (2003) 275-279
22. Yamada K.A., and Rothman S.M. Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J. Physiol. 458 (1992) 385-407
23. Zhou X., Li J.J., and Yu L.C. Plastic changes of calcitonin gene-related peptide in morphine tolerance: behavioral and immunohistochemical study in rats. J. Neurosci. Res. 74 (2003) 622-629
24. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110