Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 599, Issue 1-2, 2006, Pages 98-104

  Hiratsuka, Masahiro ^a   Nozawa, Hisayoshi ^a,b   Katsumoto, Yuya ^a   Moteki, Toshiko ^a   Sasaki, Takamitsu ^a   Konno, Yumiko ^a   Mizugaki, Michinao ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b NTT East Tohoku Hospital   (Japan)

Author keywords

CYP4A22; Denaturing HPLC; Genetic polymorphism; Haplotype

Indexed keywords

CYTOCHROME P450 4A; CYTOCHROME P450 4A22; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; EXON; FRAMESHIFT MUTATION; GENE DELETION; GENE IDENTIFICATION; GENE LOCATION; GENE MUTATION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; JAPAN; MISSENSE MUTATION; NONSENSE MUTATION; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; POPULATION GENETICS; PRIORITY JOURNAL; STOP CODON; WILD TYPE;

ALLELES; BASE SEQUENCE; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; EXONS; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; JAPAN; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; VARIATION (GENETICS);

EID: 33745917713     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2006.02.008     Document Type: Article

References (17)

1. Okita R.T., and Okita J.R. Cytochrome P450 4A fatty acid omega hydroxylases. Curr. Drug Metab. 2 (2001) 265-281
2. Imaoka S., Ogawa H., Kimura S., and Gonzalez F.J. Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney. DNA Cell. Biol. 12 (1993) 893-899
3. Hoch U., Zhang Z., Kroetz D.L., and Ortiz de Montellano P.R. Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases. Arch. Biochem. Biophys. 373 (2000) 63-71
4. Capdevila J.H., and Falck J.R. The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation. Biochem. Biophys. Res. Commun. 285 (2001) 571-576
5. McGiff J.C., and Quilley J. 20-Hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids and blood pressure. Curr. Opin. Nephrol. Hypertens. 10 (2001) 231-237
6. Roman R.J. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol. Rev. 82 (2002) 131-185
7. Ingelman-Sundberg M. Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms. Naunyn. Schmiedebergs. Arch. Pharmacol. 369 (2004) 89-104
8. Gainer J.V., Bellamine A., Dawson E.P., Womble K.E., Grant S.W., Wang Y., Cupples L.A., Guo C.Y., Demissie S., O'Donnell C.J., Brown N.J., Waterman M.R., and Capdevila J.H. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation 111 (2005) 63-69
9. Kawashima H., Naganuma T., Kusunose E., Kono T., Yasumoto R., Sugimura K., and Kishimoto T. Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein. Arch. Biochem. Biophys. 378 (2000) 333-339
10. Savas U., Hsu M.H., and Johnson E.F. Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone. Arch. Biochem. Biophys. 409 (2003) 212-220
11. Bellamine A., Wang Y., Waterman M.R., Gainer III J.V., Dawson E.P., Brown N.J., and Capdevila J.H. Characterization of the CYP4A11 gene, a second CYP4A gene in humans. Arch. Biochem. Biophys. 409 (2003) 221-227
12. Hiratsuka M., Nozawa H., Konno Y., Saito T., Konno S., and Mizugaki M. Human CYP4B1 gene in the japanese population analyzed by denaturing HPLC. Drug Metab. Pharmacokinet. 19 (2004) 114-119
13. Ebisawa A., Hiratsuka M., Sakuyama K., Konno Y., Sasaki T., and Mizugaki M. Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6 gene in Japanese individuals. Drug Metab. Pharmacokinet. 20 (2005) 294-299
14. Hiratsuka M., Kudo M., Koseki N., Ujiie S., Sugawara M., Suzuki R., Sasaki T., Konno Y., and Mizugaki M. A novel single nucleotide polymorphism of the human methylenetetrahydrofolate reductase gene in Japanese individuals. Drug Metab. Pharmacokinet. 20 (2005) 387-390
15. Laffer C.L., Laniado-Schwartzman M., Wang M.H., Nasjletti A., and Elijovich F. Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic acid in human salt-sensitive versus salt-resistant hypertension. Circulation 107 (2003) 574-578
16. Laffer C.L., Laniado-Schwartzman M., Wang M.H., Nasjletti A., and Elijovich F. 20-HETE and furosemide-induced natriuresis in salt-sensitive essential hypertension. Hypertension 41 (2003) 703-708
17. Fleming I. Cytochrome P-450 under pressure: more evidence for a link between 20-hydroxyeicosatetraenoic acid and hypertension. Circulation 111 (2005) 5-7