Chronic L-arginine supplementation enhances endurance exercise tolerance in heart failure patients

International Journal of Sports Medicine

Volumn 27, Issue 7, 2006, Pages 567-572

  Doutreleau, S ^a,b   Mettauer, B ^a   Piquard, F ^a   Rouyer, O ^a   Schaefer, A ^a   Lonsdorfer, J ^a   Geny, B ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Arginine; Endurance exercise; Heart failure; Lactate

Indexed keywords

ARGININE;

ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; DAILY LIFE ACTIVITY; EXERCISE TEST; EXERCISE TOLERANCE; HEART FAILURE; HEART RATE; HEMODYNAMICS; HUMAN; METABOLIC PARAMETERS; OXYGEN CONSUMPTION; PHYSICAL STRESS; RESPIRATORY FUNCTION; RESPIRATORY TRACT PARAMETERS; VITAMIN SUPPLEMENTATION;

ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ARGININE; EXERCISE TEST; EXERCISE TOLERANCE; HEART FAILURE; HEART FAILURE, CONGESTIVE; HEART RATE; HUMANS; LACTATES; MIDDLE AGED; OXYGEN CONSUMPTION; TIME FACTORS; TREATMENT OUTCOME;

EID: 33745912778     PISSN: 01724622     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-865847     Document Type: Article

References (31)

1. Balligand JL, Kobzik L, Han X, Kaye DM, Beihassen L, O'Hara DS, Kelly RA, Smith TW, Michel T. Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J Biol Chem 1995; 270: 14582-14586
2. 2 slope acutely in patients with severe chronic heart failure. Eur J Heart Fail 1999; 1: 187-190
3. Bocchi EA, Vilella de Moraes AV, Esteves-Filho A, Bacal F, Auler JO, Carmona MJ, Bellotti G, Ramires AF. L-arginine reduces heart rate and improves hemodynamics in severe congestive heart failure. Clin Cardiol 2000; 23: 205-210
4. Bode-Boger SM, Boger RH, Galland A, Tsikas D, Frolich JC. L-arginine-induced vasodilation in healthy humans: pharmacokinetic- pharmacodynamic relationship. Br J Clin Pharmacol 1998; 46: 489-497
5. Bradley SJ, Kingwell BA, McConell GK. Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans. Diabetes 1999; 48: 1815-1821
6. Chowdhary S, Marsh AM, Coote JH, Townend JN. Nitric oxide and cardiac muscarinic control in humans. Hypertension 2004; 43: 1023-1028
7. Geny B, Saini J, Mettauer B, Lampert E, Piquard F, Follenius M, Epailly E, Schnedecker B, Eisenmann B, Haberey P, Lonsdorfer J. Effect of short-term endurance training on exercise capacity, haemodynamics and atrial natriuretic peptide secretion in heart transplant recipients. Eur J Appl Physiol 1996; 73: 259-266
8. 2max and maximal ventilation. Eur J Appl Physiol 1982; 49: 379-387
9. Giugliano D, Marfella R, Verrazzo G, Acampora R, Coppola L, Cozzolino D, D'Onofrio F. The vascular effects of L-Arginine in humans. The role of endogenous insulin. J Clin Invest 1997; 99: 433-438
10. Hambrecht R, Hilbrich L, Erbs S, Gielen S, Fiehn E, Schoene N, Schuler G. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol 2000; 35: 706-713
11. Hansen JE, Sue DY, Wasserman K. Predicted values for clinical exercise testing. Am Rev Respir Dis 1984; 129: 49-55
12. Hare JM, Keaney JF Jr, Balligand JL, Loscalzo J, Smith TW, Colucci WS. Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs. J Clin Invest 1995; 95: 360-366
13. Kanaya Y, Nakamura M, Kobayashi N, Hiramori K. Effects of L-arginine on lower limb vasodilator reserve and exercise capacity in patients with chronic heart failure. Heart 1999; 81: 512-517
14. Katz SD, Khan T, Zeballos GA, Mathew L, Potharlanka P, Knecht M, Whelan J. Decreased activity of the L-arginine-nitric oxide metabolic pathway in patients with congestive heart failure. Circulation 1999; 99: 2113-2117
15. Koifman B, Wollman Y, Bogomolny N, Chernichowsky T, Finkelstein A, Peer G, Scherez J, Blum M, Laniado S, Iaina A et al. Improvement of cardiac performance by intravenous infusion of L-arginine in patients with moderate congestive heart failure. J Am Coll Cardiol 1995; 26: 1251-1256
16. Kraemer MD, Kubo SH, Rector TS, Brunsvold N, Bank AJ. Pulmonary and peripheral vascular factors are important determinants of peak exercise oxygen uptake in patients with heart failure. J Am Coll Cardiol 1993; 21: 641-648
17. Linossier MT, Dormois D, Bregere P, Geyssant A, Denis C. Effect of sodium citrate on performance and metabolism of human skeletal muscle during supramaximal cycling exercise. Eur J Appl Physiol 1997; 76: 48-54
18. Maxwell AJ, Anderson BE, Cooke JP. Nutritional therapy for peripheral arterial disease: a double-blind, placebo-controlled, randomized trial of HeartBar. Vasc Med 2000; 5: 11-19
19. Maxwell AJ, Cooke JP. Cardiovascular effects of L-arginine. Curr Opin Nephrol Hypertens 1998; 7: 63-70
20. Maxwell AJ, Zapien MP, Pearce GL, MacCallum G, Stone PH. Randomized trial of a medical food for the dietary management of chronic, stable angina. J Am Coll Cardiol 2002; 39: 37-45
21. Meyer K. Exercise training in heart failure: recommendations based on current research. Med Sci Sports Exerc 2001; 33: 525-531
22. Mills PC, Marlin DJ, Scott CM, Smith NC. Metabolic effects of nitric oxide synthase inhibition during exercise in the horse. Res Vet Sci 1999; 66: 135-138
23. Nagaya N, Uematsu M, Oya H, Sato N, Sakamaki F. Kyotani S, Ueno K, Nakanishi N, Yamagishi M, Miyatake K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Respir Crit Care Med 2001; 163: 887-891
24. Rector TS, Bank AJ, Mullen KA, Tschumperlin LK, Sih R, Pillai K, Kubo SH. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996; 93: 2135-2141
25. Schaefer A, Piquard F, Doutreleau S, Mettauer B, Epailly E, Eisenmann B, Lonsdorfer J, Geny B. Reduced exercise capacity is associated with reduced nitric oxide production after heart transplantation. J Thorac Cardiovasc Surg 2001; 122: 821-822
26. Schaefer A, Piquard F, Geny B, Doutreleau S, Lampert E, Mettauer B, Lonsdorfer J. L-arginine reduces exercise-induced increase in plasma lactate and ammonia. Int J Sports Med 2002; 23: 403-407
27. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 1994; 94: 1172-1179
28. Treasure CB, Alexander RW. The dysfunctional endothelium in heart failure. J Am Coll Cardiol 1993; 22: 129-134
29. Wang Y, Liu XF, Cornish KG, Zucker IH, Patel KP. Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure. Am J Physiol 2005; 288: 205-213
30. Wilson JR, Martin JL, Ferraro N. Impaired skeletal muscle nutritive flow during exercise in patients with congestive heart failure: role of cardiac pump dysfunction as determined by the effect of dobutamine. Am J Cardiol 1984; 53: 1308-1315
31. Zelis R, Sinoway LI, Musch TI, Davis D, Just H. Regional blood flow in congestive heart failure: concept of compensatory mechanisms with short and long time constants. Am J Cardiol 1988; 62: 2-8