New isomers of 4,1-benzothiazepines. The first evidence for the desmotropy of seven-membered heterocycles

Tetrahedron Letters

Volumn 47, Issue 32, 2006, Pages 5665-5667

  Csomós, Péter ^a,b   Fodor, Lajos ^a,b   Sinkkonen, Jari ^c   Pihlaja, Kalevi ^c   Bernáth, Gábor ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b Department of Pediatrics   (Hungary)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

Lactam; 4,1 Benzothiazepine; Desmotropy; Ring transformation

Indexed keywords

ALCOHOL; BENZOTHIAZEPINE DERIVATIVE; BENZOTHIAZINE DERIVATIVE; HETEROCYCLIC COMPOUND; SODIUM DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; COLUMN CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE;

EID: 33745905934     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.06.018     Document Type: Article

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24. 15N HMBC spectra; their accuracy was approximately ±1 ppm. All spectra were measured by using the standard pulse programs installed by Bruker.
25. 3): -51.4 (N-1).
26. 3): -258.5 (N-1).
27. Electron ionization mass spectra experimental. The 70 eV low-resolution spectra were recorded on a VG ZABSpec instrument equipped with an OPUS V3.3 data system. The samples were introduced through a solid-inlet system without heating the probe. The accelerating voltage was 8 kV, the temperature of the source was 433 K, and the trap current was 200 μA. The accurate mass measurements were performed by voltage scanning at a resolution of 6000-10,000, using perfluorokerosene as reference compound.
28. +: 77(6).
29. +: 77(7).