Pyrrolotriazine-5-carboxylate ester inhibitors of EGFR and HER2 protein tyrosine kinases and a novel one-pot synthesis of C-4 subsitituted pyrrole-2,3-dicarboxylate diesters

Canadian Journal of Chemistry

Volumn 84, Issue 4, 2006, Pages 528-533

  Mastalerz, Harold ^a   Gavai, Ashvinikumar V ^a   Fink, Brian ^a   Struzynski, Charles ^a   Tarrant, James ^a   Vite, Gregory D ^a   Wong, Tai W ^a   Zhang, Guifen ^a   Vyas, Dolatrai M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

EGFR; HER2; Intramolecular Wittig reaction; Pyrrole; Pyrrolotriazine

Indexed keywords

AMINO ACIDS; ENZYME INHIBITION; ESTERIFICATION; KETONES; SYNTHESIS (CHEMICAL);

DIESTERS; EGFR; HER2; INTRAMOLECULAR WITTIG REACTION; OLEFINATION; PYRROLE; PYRROLOTRIAZINE;

ENZYME KINETICS;

AMINO ACID; CARBOXYLIC ACID DERIVATIVE; DIETHYL 3,4 DIHYDRO 2H FURO[3,2 B]PYRROLE 5,6 DICARBOXYLATE; DIETHYL 4 (2 METHOXYETHOXY) 1H PYRROLE 2,3 DICARBOXYLATE; DIETHYL 4 (3 METHOXY 3 OXOPROPYL) 1H PYRROLE 2,3 DICARBOXYLATE; DIETHYL 4 METHOXY 1H PYRROLE 2,3 DICARBOXYLATE; DIETHYL 4 METHOXY 5 METHYL 1H PYRROLE 2,3 DICARBOXYLATE; DIETHYL 4 METHYL 1H PYRROLE 2,3 DICARBOXYLATE; DIETHYLACETYLENEDICARBOXYLATE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ESTER DERIVATIVE; KETONE; PYRROLINE DERIVATIVE; TRIAZINE DERIVATIVE; TRIPHENYLPHOSPHINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; DRUG SCREENING; DRUG SYNTHESIS; HORNER REACTION;

EID: 33745893827     PISSN: 00084042     EISSN: None     Source Type: Journal    
DOI: 10.1139/V06-037     Document Type: Article

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