New dual inhibitors of EGFR and HER2 protein tyrosine kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 21, 2005, Pages 4774-4779

  Fink, Brian E ^a   Vite, Gregory D ^a   Mastalerz, Harold ^a   Kadow, John F ^a   Kim, Soong Hoon ^a   Leavitt, Kenneth J ^a   Du, Karen ^a   Crews, Donald ^a   Mitt, Toomas ^a   Wong, Tai W ^a   Hunt, John T ^a   Vyas, Dolatrai M ^a   Tokarski, John S ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

EGFR; Kinase inhibitor; panHER

Indexed keywords

CARBAMIC ACID DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; HER2 PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL ASSAY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYMATIC ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN;

BINDING SITES; CARBAMATES; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MODELS, MOLECULAR; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 25144513049     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.07.027     Document Type: Article

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