Neuromodulation with levetiracetam and vagus nerve stimulation in experimental animal models of epilepsy

Acta Neurologica Belgica

Volumn 106, Issue 2, 2006, Pages 91-97

  Dedeurwaerdere, Stefanie ^a,b   Vonck, Kristl ^a   De Herdt, Veerle ^a   Waterschoot, Liesbeth ^a   De Smedt, Tim ^a   Raedt, Robrecht ^a   Wyckhuys, Tine ^a   Legros, Benjamin ^a   Van Hese, Peter ^a,c   Van Laere, Koen ^d   Delbeke, Jean ^e   Wadman, Wytse ^a,f   Boon, Paul ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c GHENT UNIVERSITY   (Belgium)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^f UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

GAERS; Kindling; Levetiracetam; Positron emission tomography; Vagus nerve stimulation

Indexed keywords

ANTICONVULSIVE AGENT; ETIRACETAM;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM FUNCTION; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE CONTROL; DRUG ABSORPTION; DRUG EFFICACY; DRUG MECHANISM; KINDLING; MEDICAL RESEARCH; NEUROMODULATION; NEUROPHYSIOLOGY; NEUROPROTECTION; NONHUMAN; RAT; RAT STRAIN; SEIZURE; SENSITIVITY ANALYSIS; TEMPORAL LOBE EPILEPSY; VAGUS NERVE STIMULATION;

EID: 33745881597     PISSN: 03009009     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Hauser W. A. Incidence and Prevalence. In Engel J., Pedley T. A. (eds.). Epilepsy, a comprehensive textbook. 1st ed. Philadelphia: Lippincot-Raven, 1998, 47-58.
2. Engel J., Dichter M. A., Schwartzkroin P. A. Basic mechanisms of human epilepsy. In: Engel J., Pedley T. A. (eds.). Epilepsy: a comprehensive textbook. first ed. Philadelphia: Lippincott-Raven, 1999, 42.41-42.14.
3. Kwan P., Brodie M. J. Early identification of refractory epilepsy. N. Engl. J. Med., 2000, 342 (5): 314-319.
4. Marescaux C., Vergnes M., Depaulis A. Genetic absence epilepsy in rats from Strasbourg - a review. J. Neural. Transm., Suppl., 1992, 35: 37-69.
5. Guey J., Bureau M., Dravet C., Roger J. A study of the rhythm of petit mal absences in children in relation to prevailing situations. The use of EEG telemetry during psychological examinations, school exercises and periods of inactivity. Epilepsia, 1969, 10 (4): 441-451.
6. Niedermeyer E. Primary (idiopathic) generalized epilepsy and underlying mechanisms. Clin. Electroencephalogr., 1996, 27 (1): 1-21.
7. Danober L., Deransart C., Depaulis A., Vergnes M., Marescaux C. Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog. Neurobiol., 1998, 55 (1): 27-57.
8. Herman S. T. Epilepsy after brain insult: targeting epileptogenesis. Neurology, 2002, 59 (9 Suppl. 5): 21-26.
9. Engel J. Jr. Mesial temporal lobe epilepsy: what have we learned? Neuroscientist, 2001, 7 (4): 340-352.
10. Racine R. J., Steingart M., McIntyre D. C. Development of kindling-prone and kindling-resistant rats: selective breeding and electrophysiological studies. Epilepsy research, 1999, 35 (3): 183-195.
11. Anisman H., McIntyre D. C. Conceptual, Spatial, and Cue Learning in the Morris Water Maze in Fast or Slow Kindling Rats: Attention Deficit Comorbidity. Journal of Neuroscience, 2002, 22 (17): 7809-7817.
12. Patsalos P. N. Pharmacokinetic profile of levetiracetam: toward ideal characteristics. Pharmacol. Ther., 2000, 85 (2): 77-85.
13. Loscher W., Honack D., Rundfeldt C. Anti-epileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. J. Pharmacol. Exp. Ther., 1998, 284 (2): 474-479.
14. Stratton S. C., Large C. H., Cox B., Davies G., Hagan R. M. Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model. Epilepsy Res., 2003, 53 (1-2): 95-106.
15. De Smedt T., Vonck K., Raedt R., Dedeurwaerdere S., Claeys P., Legros B., Wyckhuys T., Wadman W., Boon P. Rapid kindling in preclinical anti-epileptic drug development: the effect of levetiracetam. Epilepsy Res., 2005, 67 (3): 109-116.
16. Sasa M., Yan H., Nagayama T., Seriwaka T. Anti-epileptogenic Properties of Levetiracetam in the Spontaneously Epileptic Rat (SER). Epilepsia, 2003, 44 (Suppl. 8): 175-176.
17. Yan H. D., Ji-qun C., Ishihara K., Nagayama T., Serikawa T., Sasa M. Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER). Epilepsia, 2005, 46 (8): 1170-1177.
18. Dedeurwaerdere S., Boon P., De Smedt T., Claeys P., Raedt R., Bosman T., Van Hese P., Van Maele G., Vonck K. Chronic levetiracetam treatment early in life decreases epileptiform events in young GAERS, but does not prevent the expression of spike and wave discharges during adulthood. Seizure, 2005, 14 (6): 403-411.
19. Ji-qun C., Ishihara K., Nagayama T., Serikawa T., Sasa M. Long-lasting antiepileptic effects of levetiracetam against epileptic seizures in the spontaneously epileptic rat (SER): differentiation of levetiracetam from conventional antiepileptic drugs. Epilepsia, 2005, 46 (9): 1362-1370.
20. Ben-Menachem E. Vagus-nerve stimulation for the treatment of epilepsy. Lancet Neurol., 2002, 1(8): 477-482.
21. Salinsky M. C. Vagus Nerve Stimulation As Treatment for Epileptic Seizures. Curr. Treat Options Neurol., 2003, 5 (2): 111-120.
22. Rutecki P. Anatomical, physiological, and theoretical basis for the antiepileptic effect of vagus nerve stimulation. Epilepsia, 1990, 31 (Suppl. 2): 1-6.
23. Lockard J. S., Congdon W. C., DuCharme L. L. Feasibility and safety of vagal stimulation in monkey model. Epilepsia, 1990, 31 (Suppl. 2): 20-26.
24. Woodbury D. M., Woodbury J. W. Effects of vagal stimulation on experimentally induced seizures in rats. Epilepsia, 1990, 31 (Suppl. 2): 7-19.
25. Woodbury J. W., Woodbury D. M. Vagal stimulation reduces the severity of maximal electroshock seizures in intact rats: use of a cuff electrode for stimulating and recording. Pacing Clin. Electrophysiol., 1991, 14 (1): 94-107.
26. Zabara J. Inhibition of experimental seizures in canines by repetitive vagal stimulation. Epilepsia, 1992, 33 (6): 1005-1012.
27. McLachlan R. S. Suppression of interictal spikes and seizures by stimulation of the vagus nerve. Epilepsia, 1993, 34 (5): 918-923.
28. Takaya M., Terry W. J., Naritoku D. K. Vagus nerve stimulation induces a sustained anticonvulsant effect. Epilepsia, 1996, 37 (11): 1111-1116.
29. Munana K. R., Vitek S. M., Tarver W. B., Saito M., Skeen T. M., Sharp N. J., Olby N. J., Haglund M. M. Use of vagal nerve stimulation as a treatment for refractory epilepsy in dogs. J. Am. Vet. Med. Assoc., 2002, 221 (7): 977-983.
30. Vonck K., Boon P., Van Large K., D'Have M., Vandekerckhove T., O'Connor S., Brans B., Dierckx R., De Reuck J. Acute single photon emission computed tomographic study of vagus nerve stimulation in refractory epilepsy. Epilepsia, 2000, 41 (5): 601-609.
31. Van Laere K., Vonck K., Boon P., Versupt J., Dierckx R. Perfusion SPECT Changes After Acute and Chronic Vagus Nerve Stimulation in Relation to Prestimulus Condition and Long-Term Clinical Efficacy. The Journal of Nuclear Medicine, 2002, 43 (6): 733-744.
32. Chae J. H., Nahas Z., Lomarev M., Denslow S., Lorberbaum J. P., Bohning D. E., George M. S. A review of functional neuroimaging studies of vagus nerve stimulation (VNS). J. Psychiatr. Res., 2003, 37 (6): 443-455.
33. Dedeurwaerdere S., Cornelissen B., Van Laere K., Vonck K., Achten E., Slegers G., Boon P. Small animal positron emission tomography during vagus nerve stimulation in rats: A pilot study. Epilepsy Research, 2005, 67 (3): 133-141.
34. Dedeurwaerdere S., Vonck K., Claeys P., Van Hese P., D'Have M., Grisar T., Naritoku D., Boon P. Acute vagus nerve stimulation does not suppress spike and wave discharges in "Genetic Absence Epilepsy Rats from Strasbourg". Epilepsy research, 2004, 59 (2-3): 191-198.
35. Dedeurwaerdere S., Vonck K., Van Hese P., Wadman W., Boon P. The acute and chronic effect of vagus nerve stimulation in genetic absence epilepsy rats from Strasbourg (GAERS). Epilepsia, 2005, 46 Suppl. 5: 94-97.
36. Dedeurwaerdere S., Gilby K., Vonck K., Delbeke J., Boon P., McIntyre D. Vagus nerve stimulation does not affect spatial memory in Fast rats, but has both anti-convulsive and pro-convulsive effects on amygdala kindled seizures. Neuroscience, 2006, In Press.
37. Vonck K., Boon P., D'Have M., Vandekerckhove T., O'Connor S., De Reuck J. Long-term results of vagus nerve stimulation in refractory epilepsy. Seizure, 1999, 8 (6): 328-334.