Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts

Journal of Experimental Medicine

Volumn 203, Issue 7, 2006, Pages 1713-1720

  Li, Ou ^a,c   Chang, Xing ^a   Zhang, Huiming ^a,c   Kocak, Ergun ^a   Ding, Cheng ^a,c   Zheng, Pan ^a,c   Liu, Yang ^a,b,c  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b INSTITUTE OF BIOPHYSICS   (China)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD24 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; HOMEOSTASIS; IMMUNE SYSTEM; LYMPHOCYTOPENIA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD24; CELL PROLIFERATION; CELLS, CULTURED; HOMEOSTASIS; LYMPHOCYTE DEPLETION; LYMPHOPENIA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; T-LYMPHOCYTES;

EID: 33745866283     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20052293     Document Type: Article

References (31)

1. Butz, E.A., and M.J. Bevan. 1998. Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. Immunity. 8:167-175.
2. Murali-Krishna, K., J.D. Altman, M. Suresh, D.J. Sourdive, A.J. Zajac, J.D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity. 8:177-187.
3. Wang, X.Z., S.E. Stepp, M.A. Brehm, H.D. Chen, L.K. Selin, and R.M. Welsh. 2003. Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs. Immunity. 18:631-642.
4. Lohman, B.L., and R.M. Welsh. 1998. Apoptotic regulation of T cells and absence of immune deficiency in virus-infected gamma interferon receptor knockout mice. J. Virol. 72:7815-7821.
5. Goldrath, A.W., and M.J. Bevan. 1999. Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity. 11:183-190.
6. Goldrath, A.W., L.Y. Bogatzki, and M.J. Bevan. 2000. Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J. Exp. Med. 192:557-564.
7. Cho, B.K., V.P. Rao, Q. Ge, H.N. Eisen, and J. Chen. 2000. Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J. Exp. Med. 192:549-556.
8. Min, B., R. McHugh, G.D. Sempowski, C. Mackall, G. Foucras, and W.E. Paul. 2003. Neonates support lymphopenia-induced proliferation. Immunity. 18:131-140.
9. Dudley, M.E., J.R. Wunderlich, P.F. Robbins, J.C. Yang, P. Hwu, D.J. Schwartzentruber, S.L. Topalian, R. Sherry, N.P. Restifo, A.M. Hubicki, et al. 2002. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science. 298:850-854.
10. Ernst, B., D.S. Lee, J.M. Chang, J. Sprent, and C.D. Surh. 1999. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity. 11:173-181.
11. Min, B., G. Foucras, M. Meier-Schellersheim, and W.E. Paul. 2004. Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire. Proc. Natl. Acad. Sci. USA. 101:3874-3879.
12. Ge, Q., A. Bai, B. Jones, H.N. Eisen, and J. Chen. 2004. Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8+ T cells expressing the same or different T cell receptors. Proc. Natl. Acad. Sci. USA. 101:3041-3046.
13. Schonland, S.O., J.K. Zimmer, C.M. Lopez-Benitez, T. Widmann, K.D. Ramin, J.J. Goronzy, and C.M. Weyand. 2003. Homeostatic control of T-cell generation in neonates. Blood. 102:1428-1434.
14. Kearney, E.R., T.L. Walunas, R.W. Karr, P.A. Morton, D.Y. Loh, J.A. Bluestone, and M.K. Jenkins. 1995. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 155:1032-1036.
15. Bai, X.-F., J.-X. Gao, Q. Liu, J. Wen, P. Zheng, and Y. Liu. 2001. On the site and mode of antigen presentation for the initiation of clonal expansion of CD8 T cells specific for a natural tumor antigen. Cancer Res. 61:6860-6867.
16. Bai, X.F., J. Liu, K.F. May Jr., Y. Guo, P. Zheng, and Y. Liu. 2002. B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo. Blood. 99:2880-2889.
17. Prlic, M., B.R. Blazar, A. Khoruts, T. Zell, and S.C. Jameson. 2001. Homeostatic expansion occurs independently of costimulatory signals. J. Immunol. 167:5664-5668.
18. Li, O., P. Zheng, and Y. Liu. 2004. CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host. J. Exp. Med. 200:1083-1089.
19. Wu, Y., Q. Zhou, P. Zheng, and Y. Liu. 1998. CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen. J. Exp. Med. 187:1151-1156.
20. Liu, Y., R.H. Wenger, M. Zhao, and P.J. Nielsen. 1997. Distinct co-stimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes. J. Exp. Med. 185:251-262.
21. Schluns, K.S., W.C. Kieper, S.C. Jameson, and L. Lefrancois. 2000. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1:426-432.
22. Tan, J.T., E. Dudl, E. LeRoy, R. Murray, J. Sprent, K.I. Weinberg, and C.D. Surh. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc. Natl. Acad. Sci. USA. 98:8732-8737.
23. Nielsen, P.J., B. Lorenz, A.M. Muller, R.H. Wenger, F. Brombacher, M. Simon, T. von der Weid, W.J. Langhorne, H. Mossmann, and G. Kohler. 1997. Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice. Blood. 89:1058-1067.
24. Bai, X.F., J.Q. Liu, X. Liu, Y. Guo, K. Cox, J. Wen, P. Zheng, and Y. Liu. 2000. The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis. J. Clin. Invest. 105:1227-1232.
25. Surh, C.D., and J. Sprent. 2000. Homeostatic T cell proliferation: how far can T cells be activated to self-ligands? J. Exp. Med. 192:F9-F14.
26. Bai, X.F., O. Li, Q. Zhou, H. Zhang, P.S. Joshi, X. Zheng, Y. Liu, Y. Wang, and P. Zheng. 2004. CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis. J. Exp. Med. 200:447-458.
27. Ge, Q., D. Palliser, H.N. Eisen, and J. Chen. 2002. Homeostatic T cell proliferation in a T cell-dendritic cell coculture system. Proc. Natl. Acad. Sci. USA. 99:2983-2988.
28. Chu, Y.-W., S.A. Memon, S.O. Sharrow, F.T. Hakim, M. Eckhaus, P.J. Lucas, and R.E. Gress. 2004. Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function. Blood. 104:1110-1119.
29. Bevan, M.J. 1977. In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature. 269:417-418.
30. Kay, R., F. Takei, and R.K. Humphries. 1990. Expression cloning of a cDNA encoding M1/69-J11d heat-stable antigens. J. Immunol. 145:1952-1959.
31. Lutz, M.B., N. Kukutsch, A.L. Ogilvie, S. Rossner, F. Koch, N. Romani, and G. Schuler. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods. 223:77-92.