Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition

Toxicology and Applied Pharmacology

Volumn 214, Issue 2, 2006, Pages 109-117

  Ishihara, Yasuhiro ^a   Shiba, Dai ^a   Shimamoto, Norio ^b  

^a OSAKA UNIVERSITY   (Japan)

^b TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Cytochrome P450; Hepatocyte; Oxidative stress; Quinone; Redox cycle

Indexed keywords

1,4 BENZOQUINONE; 2,3 DIMETHOXY 1,4 NAPHTHOQUINONE; ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; CYTOCHROME P450; DEFEROXAMINE; DIPHENYLIODONIUM SALT; ENZYME INHIBITOR; GLUTATHIONE; GLUTATHIONE DISULFIDE; IRON CHELATING AGENT; KETOCONAZOLE; METYRAPONE; PROADIFEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE INHIBITOR; SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; LIVER TOXICITY; MALE; MICROSOME; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; RAT; RAT STRAIN;

ANIMALS; ANTIOXIDANTS; BENZOQUINONES; CATECHOLAMINES; CELL SURVIVAL; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME INHIBITORS; GLUTATHIONE DISULFIDE; HEPATOCYTES; IMIDAZOLINES; IRON CHELATING AGENTS; KETOCONAZOLE; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; MALE; METYRAPONE; MOLECULAR STRUCTURE; NADP; NAPHTHOQUINONES; OXIDATIVE STRESS; PROADIFEN; RATS; RATS, WISTAR; SUPEROXIDES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 33745864853     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.12.003     Document Type: Article

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