Potential role for IL-23 in hepatic ischemia/reperfusion injury

Inflammation Research

Volumn 55, Issue 5, 2006, Pages 177-178

  Husted, T L ^a   Blanchard, J ^a   Schuster, R ^a   Shen, H ^a   Lentsch, A B ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

IL 12; IL 23; Inflammation; Kupffer cells; Liver

Indexed keywords

ANTIBODY; CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 23; INTERLEUKIN 23P19; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY REACTION; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; HEPATITIS; KUPFFER CELL; LIVER ISCHEMIA; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPERFUSION INJURY;

ANIMALS; CELLS, CULTURED; GENE EXPRESSION REGULATION; INTERLEUKIN-12; INTERLEUKIN-23; INTERLEUKIN-23 SUBUNIT P19; INTERLEUKINS; KUPFFER CELLS; LIVER; MALE; MICE; MICE, INBRED C57BL; REPERFUSION INJURY; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33745850100     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-006-0073-1     Document Type: Article

References (9)

1. Lentsch AB, Kato A, Yoshidome H, McMasters KM, Edwards MJ. Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology 2000; 32: 169-73.
2. Jaeschke H, Smith CW. Mechanisms of neutrophil-induced parenchymal cell injury. J Leukoc Biol 1997; 61: 647-53.
3. Lentsch AB, Yoshidome H, Kato A, Warner RL, Cheadle WG, Ward PA et al. Requirement for interleukin-12 in the pathogenesis of warm hepatic ischemia/reperfusion injury in mice. Hepatology 1999; 30: 1448-53.
4. Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000; 13: 715-25.
5. Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol. 2005; 5: 521-31.
6. Lentsch AB, Yoshidome H, Cheadle WG, Miller FN, Edwards MJ. Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and KC. Hepatology 1998; 27: 1172-7.
7. Okaya T, Blanchard J, Schuster R, Kuboki S, Husted TL, Caldwell CC et al. Age-dependent responses to hepatic ischemia/reperfusion injury. Shock 2005; 24: 421-7.
8. Caldwell CC, Okaya T, Martignoni A, Husted TL, Schuster R, Lentsch AB. Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia/reperfusion. Am. J. Physiol. Gastrointest. Liver Physiol. 2005; 289: G969-76.
9. Aggarwal S, Ghilardi N, Xie M-H, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003; 278: 1910-4.