Iron and glutathione at the crossroad of redox metabolism in neurons

Biological Research

Volumn 39, Issue 1, 2006, Pages 157-165

  Aracena, Paula ^a   Aguirre, Pabla ^a   Muñoz, Pablo ^a   Núñez, Marco Tulio ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Glutathione metabolism; Iron accumulation; Iron metabolism; Neurodegeneration; Neurons; Oxidative stress

Indexed keywords

FERROPORTIN 1; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PANTOTHENATE KINASE;

CELL DEATH; CELL FUNCTION; CONFERENCE PAPER; CORRELATION ANALYSIS; DEGENERATIVE DISEASE; FUNCTIONAL DISEASE; GENE MUTATION; GLUTATHIONE METABOLISM; HUMAN; IRON INTAKE; IRON METABOLISM; NERVE CELL; NERVE DEGENERATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBSTANTIA NIGRA; SYSTEMATIC REVIEW;

EID: 33745846341     PISSN: 07169760     EISSN: 07176287     Source Type: Journal    
DOI: 10.4067/S0716-97602006000100017     Document Type: Conference Paper

References (43)

1. ADAMS JD JR, KLAIDMAN LK, ODUNZE IN, SHEN HC, MILLER CA (1991) Brain levels of glutathione, glutathione disulfide, and vitamin E. Mol Chem Neuropathol 14: 213-226
2. AGUIRRE P, MENA N, TAPIA V, ARREDONDO M, NÚÑEZ MT (2005) Iron homeostasis in neuronal cells: a role for IREG1. BMC Neurosci 6:3
3. ANDERSEN JK (2004) Iron dysregulation and Parkinson's disease. J Alzheimer's Dis 6: S47-52
4. BEARD J (2003) Iron deficiency alters brain development and functioning. J Nutr 133: 1468S-1472S
5. BURDO JR, MENZIES SL, SIMPSON IA, GARRICK LM, GARRICK MD, DOLAN KG, HAILE DJ, BEARD JL, CONNOR JR (2001) Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J Neurosci Res 66: 1198-1207
6. CASADESUS G, SMITH MA, ZHU X, ALIEV G, CASH AD, HONDA K, PETERSEN RB, PERRY G. (2004) Alzheimer disease: evidence for a central pathogenic role of iroh-mediated reactive oxygen species. J Alzheimer's Dis 6: 165-169
7. CHO HY, REDDY SP, DEBIASE A, YAMAMOTO M, KLEEBERGER SR (2005) Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med 38: 325-343
8. CRICHTON RR, WARD RJ (1992) Iron metabolism: New perspectives in view. Biochemistry 31: 11255-11264
9. CROMPTON DE, CHINNERY PF, FEY C, CURTIS AR, MORRIS CM, KIERSTAN J, BURT A, YOUNG F, COULTHARD A, CURTIS A, INCE PG, BATES D, JACKSON MJ, BURN J (2002) Neuroferritinopathy: A window on the role of iron in neurodegeneration. Blood Cells Mol Dis 29: 522-531
10. DEREGNIER R, NELSON C, THOMAS K, WEWERKA S, GEORGIEFF M (2000) Neurophysiologic evaluation of auditory recognition memory in healthy newborn infants and infants of diabetic mothers. J Pediatr 137: 777-784
11. DEVALIA V, CARTER K, WALKER AP, PERKINS SJ, WORWOOD M, MAY A, DOOLEY JS (2002) Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3). Blood 100: 695-697
12. DICKINSON DA, LEVONEN AL, MOELLERING DR, ARNOLD EK, ZHANG H, DARLEY-USMAR VM, FORMAN HJ (2004) Human glutamate cysteine ligase gene regulation through the electrophile response element. Free Radic Biol Med 37: 1152-1159
13. DIPATTI MC, PERSICHINI T, MAZZONE V, POLTICELLI F, COLASANTI M, MUSCI G (2004) Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis. Neurosci Lett 363: 182-186
14. DROGE W (2003) Oxidative stress and aging. Adv Exp Med Biol 543: 191-200
15. DRUKARCH B, SCHEPENS E, JONGENELEN CA, STOOF JC, LANGEVELD CH (1997) Astrocytemediated enhancement of neuronal survival is abolished by glutathione deficiency. Brain Res 770: 123-130
16. GOTZ ME, DOUBLE K, GERLACH M, YOUDIM MB, RIEDERER P (2004) The relevance of iron in the pathogenesis of Parkinson's disease. Ann NY Acad Sci 1012: 193-208
17. GUNSHIN H, MACKENZIE B, BERGER UV, GUNSHIN Y, ROMERO MF, BORON WF, NUSSBERGER S, GOLLAN JL, HEDIGER MA (1997) Cloning and characterization of a mammalian proton-coupled metalion transporter. Nature 388: 482-488
18. HALLIWELL B, GUTTERIDGE JMC (1999) Oxidative stress: Adaptation, damage, repair and death. In: Free Radicals in Biology and Medicine. 3rd Ed. Oxford, UK: Oxford University Press. pp: 246-350
19. HARDY PA, GASH D, YOKEL R, ANDERSEN A, AI Y, ZHANG Z (2005) Correlation of R2 with total iron concentration in the brains of rhesus monkeys. J Magn Reson Imaging 21: 118-127
20. HAYFLICK SJ (2003) Unraveling the Hallervorden-Spatz syndrome: pantothenate kinase-associated neurodegeneration is the name. Curr Opin Pediatr 15: 572-527.
21. HUBERT N, HENTZE MW. (2002) Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function. Proc Natl Acad Sci USA 99: 12345-12350
22. JEONG SY, DAVID S (2003) Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system. J Biol Chem 278: 27144-27148
23. JEYAPAUL J, JAISWAL AK (2000) Nrf2 and c-Jun regulation of antioxidant response element (ARE)-mediated expression and induction of gamma-glutamylcysteine synthetase heavy subunit gene. Biochem Pharmacol 59: 1433-1439
24. LIU H, WANG H, SHENVI S, HAGEN TM, LIU RM (2004) Glutathione metabolism during aging and in Alzheimer disease. Ann N Y Acad Sci 1019: 346-349
25. MACKENZIE B, HEDIGER MA (2004) SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1. Pflugers Arch Eur J Physiol 447: 571-579
26. MCKIE AT, BARLOW DJ (2004) The SLC40 basolateral iron transporter family (IREG1/ ferroportin/MTP1). Pflugers Arch Eur J Physiol 447: 801-806
27. MCKIE AT, MARCIANI P, ROLFS A, BRENNAN K, WEHR K, BARROW D, MIRET S, BOMFORD A, PETERS TJ, FARZANEH F, HEDIGER MA, HENTZE MW, SIMPSON RJ (2000) A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5 299-309
28. MEISTER A (1983) Selective modification of glutathione metabolism. Science 220: 472-477
29. NAKASO K, YANO H, FUKUHARA Y, TAKESHIMA T, WADA-ISOE K, NAKASHIMA K (2003) P13K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells. FEBS Lett 546: 181-184
30. NELSON C, ERIKSON K, PINERO D, BEARD JL (1997) Alterations in dopamine metabolism in iron deficient rats. J Nutr 12: 2282-2288
31. NÚÑEZ MT, GALLARDO V, MUÑOZ P, TAPIA V, ESPARZA A, SALAZAR J, SPEISKY H (2004) Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells. Free Radic Biol Med 37: 953-960
32. OMAR RA, CHYAN YJ, ANDORN AC, POEGGELER B, ROBAKIS NK, PAPPOLLA MA (1999) Increased expression but reduced activity of antioxidant enzymes in Alzheimer's Disease. J Alzheimer's Dis 1: 39-145
33. PERRY TL, YONG VW (1986) Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients. Neurosci Lett 67 269-274
34. RIEDERER P, SOFIC E, RAUSCH WD, SCHMIDT B, REYNOLDS GP, JELLINGER K, YOUDIM MB (1989) Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J Neurochem 52: 515-520
35. RUSSELL RL, SIEDLAK SL, RAINA AK, BAUTISTA JM, SMITH MA, PERRY G (1999) Increased neuronal glucose-6-phosphate dehydrogenase and sulphydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease. Arch Biochem Biophys 370: 236-239
36. SHOHAM S, YOUDIM MB (2002) The effects of iron deficiency and iron and zinc supplementation on rat hippocampus ferritin. J Neural Transm 109: 1241-1256
37. SOFIC E, LANGE KW, JELLINGER K, RIEDERER P (1992) Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease. Neurosci Lett 142: 128-130
38. SOLTANINASSAB SR, SEKHAR KR, MEREDITH MJ, FREEMAN ML (2000) Multi-Faceted Regulation of g-Glutamylcysteine Synthetase. J Cell Physiol 182: 163-170
39. WANG XS, ONG WY, CONNOR JR (2003) Quinacrine attenuates increases in divalent metal transporter-1 and iron levels in the rat hippocampus, after kainate-induced neuronal injury. Neuroscience 120: 21-29
40. YANG H, WANG J, HUANG Z, OU X, LU S (2001) Cloning and characterization of the 5′-flanking region of the rat glutamate-cysteine ligase catalytic subunit. Biochem J 357: 447-455
41. YANG F, WANG X, HAILE DJ, PIANTADOSI CA, GHIO AJ (2002) Iron increases expression of iron-export protein MTP1 in lung cells. Am. J. Physiol Lung Cell Mol Physiol 283: L932-L939
42. ZECCA L, GALLORINI M, SCHÜNEMANN V, ALFRED X, TRAUTWEIN, AX, GERLACH M, RIEDERER, P, VEZZONI P, TAMPELLINI D (2001) Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: Consequences for iron storage and neurodegenerative processes. J Neurochem 76: 1766-1773
43. ZHU X, RAINA AK, LEE HG, CASADESUS G, SMITH MA, PERRY G (2004) Oxidative stress signaling in Alzheimer's disease. Brain Res 1000: 32-39