Functional analysis of a metal response element in the regulatory region of flounder cytochrome P450 1A and implications for environmental monitoring of pollutants

Toxicological Sciences

Volumn 92, Issue 2, 2006, Pages 387-393

  Lewis, Nick A ^a   Williams, Tim D ^a   Chipman, James K ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Cadmium; CYP 1A; Flounder; Gene expression; Metal response element

Indexed keywords

3 METHYLCHOLANTHRENE; CADMIUM; CYTOCHROME P450 1A; LIVER PROTEIN; LUCIFERASE; METAL DERIVATIVE; NUCLEAR PROTEIN; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENVIRONMENTAL MONITORING; ENZYME ASSAY; ENZYME INDUCTION; ENZYME REGULATION; FLOUNDER; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; GENE MUTATION; GENE PROBE; GENETIC VARIABILITY; INCUBATION TIME; METAL RESPONSE ELEMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; POLLUTANT; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; REPORTER GENE; SITE DIRECTED MUTAGENESIS; VERTEBRATE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL MARKERS; CADMIUM; CELL LINE, TUMOR; CYPRINIDAE; ENVIRONMENTAL MONITORING; FLOUNDER; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; LIVER; METHYLCHOLANTHRENE; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; TRANSFECTION; WATER POLLUTANTS, CHEMICAL;

PLATICHTHYS FLESUS; PLEURONECTOIDEI; VERTEBRATA;

EID: 33745800615     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl023     Document Type: Article

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