The diagnostic value of serum interleukins 6 and 8 in children with acute gastroenteritis

Journal of Pediatric Gastroenterology and Nutrition

Volumn 43, Issue 1, 2006, Pages 25-29

  Lin, Chien Hung ^a   Hsieh, Chiea Chang ^a   Chen, Shu Jen ^a   Wu, Tzee Chung ^a   Chung, Ruey Lung ^a   Tang, Ren Bin ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

C reactive protein (CRP); Gastroenteritis; Interleukin 6 (IL 6); Interleukin 8 (IL 8)

Indexed keywords

ANTIBIOTIC AGENT; C REACTIVE PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8;

ACUTE GASTROENTERITIS; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DISEASE MARKER; EARLY DIAGNOSIS; FEMALE; HUMAN; IMMUNE RESPONSE; INFLAMMATORY DISEASE; MALE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; UNNECESSARY PROCEDURE; VIRUS INFECTION;

ACUTE DISEASE; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CHILD, PRESCHOOL; DYSENTERY, BACILLARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTROENTERITIS; HUMANS; INFANT; INTERLEUKIN-6; INTERLEUKIN-8; MALE; ROTAVIRUS INFECTIONS; SALMONELLA INFECTIONS; SENSITIVITY AND SPECIFICITY; YERSINIA INFECTIONS;

BACTERIA (MICROORGANISMS);

EID: 33745796167     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpg.0000235764.30743.5b     Document Type: Article

References (31)

1. Cadwgan AM, Watson WA, Laing RB, et al. Presenting clinical features and C-reactive protein in the prediction of a positive stool culture in patients with diarrhoea. J Infect 2000;41:159-61.
2. Huicho L, Campos M, Rivera J, et al. Fecal screening tests in the approach to acute infectious diarrhea: a scientific overview. Pediatr Infect Dis J 1996;15:486-94.
3. Moldawer LL. Biology of proinflammatory cytokines and their antagonists. Crit Care Med 1994;22:S3-7.
4. Sullivan JS, Kilpatrick L, Costarino AT Jr, et al. Correlation of plasma cytokine elevations with mortality rate in children with sepsis. J Pediatr 1992;120:510-5.
5. Emery P, Salmon M. The immune response 2: systemic mediators of inflammation. Br J Hosp Med 1991;45:164-8.
6. Saez-Llorens X, Lagrutta F. The acute phase host reaction during bacterial infection and its clinical impact in children. Pediatr Infec Dis J 1993;12:87-3.
7. De Beaux AC, Ross JA, Maingay JP, et al. Proinflammatory cytokine release by peripheral blood mononuclear cells from patients with acute pancreatitis. Br J Surg 1996;83:1071-5.
8. Doellner H, Arntzen KJ, Haereid PE, et al. Interleukin-6 concentrations in neonates evaluated for sepsis. J Pediatr 1998;132:295-9.
9. Buck C, Bundschu J, Gallati H, et al. Interleukin-6: a sensitive parameter for early diagnosis of neonatal bacterial infection. Pediatrics 1994;93:54-8.
10. Fassbender K, Dempfle CE, Mielke O. Proinflammatory cytokines: indicators of infection in high-risk patients. J Lab Clin Med 1997;130:535-9.
11. Parikh AA, Salzman AL, Fischer JE, et al. Interleukin-1 beta and interferon-gamma regulate interleukin-6 production in cultured human intestinal epithelial cells. Shock 1997;8:249-55.
12. Pritts T, Hungness E, Wang Q, et al. Mucosal and enterocyte IL-6 production during sepsis and endotoxemia - role of transcription factors and regulation by the stress response. Am J Surg 2002;183:372-83.
13. McAlindon ME, Mahida YR. Cytokines and the gut. Eur J Gastroenterol Hepatol 1997;9:1045-50.
14. Mangiarotti P, Moulin F, Palmer P, et al. Interferon-alpha in viral and bacterial gastroenteritis: a comparison with C-reactive protein and interleukin-6. Acta Paediatr 1999;88:592-4.
15. Kutukculer N, Caglayan S. Tumor necrosis factor-alpha and interleukin-6 in stools of children with bacterial and viral gastroenteritis. J Pediatr Gastroenterol Nutr 1997;25:556-7.
16. Vaisman N, Leibovitz E, Dagan R, et al. The involvement of IL-6 and IL-8 in acute invasive gastroenteritis of children. Cytokine 22:194-7.
17. + dendritic cells initiating cytokine expression. Eur J Immunol 1999;29:1107-15.
18. Li Y, Reichenstein K, Ullrich R, et al. Effect of in situ expression of human interleukin-6 on antibody responses against Salmonella typhimurium antigens. FEMS Immunol Med Microbiol 2003;37:135-45.
19. Eckmann L, Kagnoff MF, Fierer J. Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infect Immun 1993;61:4569-74.
20. McCormick BA, Colgan SP, Delp-Archer C, et al. Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils. J Cell Biol 1993;123:895-907.
21. Sansonetti PJ, Arondel J, Huerre M, et al. Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis. Infect Immun 1999;67:1471-80.
22. Mukaida N. Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation. Int J Hematol 2000;72:391-8.
23. Franz AR, Steinbach G, Kron M, et al. Reduction of unnecessary antibiotic therapy in newborn infants using interleukin-8 and C-reactive protein as markers of bacterial infections. Pediatrics 1999;104:447-53.
24. Franz AR, Bauer K, Schalk A, et al. Measurement of interleukin 8 in combination with C-reactive protein reduced unnecessary antibiotic therapy in newborn infants: a multicenter randomized controlled trial. Pediatrics 2004;114:1-8.
25. Franz AR, Kron M, Pohlandt F, et al. Comparison of procalcitonin with interleukin 8, C-reactive protein and differential white blood cell count for the early diagnosis of bacterial infections in newborn infants. Pediatr Infect Dis J 1999;18:666-71.
26. Sheth R, Anderson J, Sato T, et al. Rotavirus stimulates IL-8 secretion from cultured epithelial cells. Virology 1996;221:251-9.
27. Daig R, Andus T, Aschenbrenner E, et al. Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut 1996;38:216-22.
28. Shabib SM, Khabar KSA, Siddiqui S, et al. Elevated levels of interleukin-8 in sera of children with severe intractable diarrhea. J Pediatr Gastroenterol Nutr 1998;27:254.
29. Boissieu DD, Lebon P, Badoual J, et al. Rotavirus induces α-interferon release in children with gastroenteritis. J Pediatr Gastroenterol Nutr 1993;16:29-32.
30. Azim T, Zaki MH, Podder G. Rotavirus-specific subclass antibody and cytokine responses in Bangladeshi children with rotavirus diarrhoea. J Med Virol 2003;69(2):286-95.
31. Hesse DG, Tracey KJ, Fong Y, et al. Cytokine appearance in human endotoxemia and primate bacteremia. Surg Gynecol Obstet 1988;166:147-53.