Immunie sexual dimorphism: Can sex steroids affect the Th1/Th2 cytokine profile?;Dimorfismo sexual inmunitario: ¿Pueden los esteroides sexuales polarizar el perfil de citocinas Th1/Th2?

Revista de Investigacion Clinica

Volumn 58, Issue 2, 2006, Pages 161-169

  De León Nava, Marco ^a   Morales Montor, Jorge ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Cytokines; Immune response; Polarization; Sex steroids; Th1, Th2

Indexed keywords

ANTIGEN; CYTOKINE; IMMUNOLOGIC FACTOR; SEX HORMONE; GESTAGEN;

AUTOREGULATION; CYTOKINE RELEASE; ENDOCRINE SYSTEM; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; MALE; MAMMAL; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SEX DIFFERENCE; TH1 CELL; TH2 CELL; BIOSYNTHESIS; IMMUNITY; IMMUNOLOGY; PHYSIOLOGY; SEXUAL DEVELOPMENT;

CYTOKINES; FEMALE; GONADAL STEROID HORMONES; HUMANS; IMMUNITY; MALE; PROGESTINS; SEX CHARACTERISTICS; TH1 CELLS; TH2 CELLS;

EID: 33745793204     PISSN: 00348376     EISSN: 00348376     Source Type: Journal    
DOI: None     Document Type: Review

References (65)

1. Besedovsky HO, Del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr Revs 1996; 17: 64-102.
2. Morales-Montor J, Chavarria A, De León MA, Del Castillo LI, Escobedo, EG, Sánchez EN, Vargas JA, Hernández-Flares M, Romo-González T, Larralde C. Host gender in parasitic infections of mammals: an evaluation of the female host supremacy paradigm. J Parasitol 2004; 90: 531-46.
3. Armstrong MD, Klein JR. Immune-endocrine interactions of the hypothalamus-pituitary-thyroid axis: integration, communication and homeostasis. Arch Immunol Ther Exp (Warsz) 2001; 49: 231-7:
4. Chikanza IC, Grossman AB. Reciprocal interactions between the neuroendocrine and immune systems during inflammation. Rheum Dis Clin North Am 2000; 26: 693-711.
5. Giron-Gonzalez JA, Moral FJ, Elvira J, Garcia-Gil D, Guerrero F, Gavilán I, Escobar L. Consistent production of a higher TH1:TH2 cytokine ratio by stimulated T cells in men compared with women. Eur J Endocrinol 2000; 43: 31-6.
6. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 2348-57.
7. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383: 787-93.
8. Lucey DR, Clerici M, Shearer GM. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin Microbiol Rev 1996; 9(4): 532-62.
9. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996; 17: 138-46.
10. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7: 145-73.
11. Romagnani S. Lymphokine production by human T cells in diseases states. Annu Rev Immunol 2004; 12: 227-57.
12. D'Ambrosio D, Iellem A, Colantonio L, Clissi B, Pardi R, Sinigaglia F. Localization of Th-cell subsets in inflammation: differential thresholds for extravasation of Th1 and Th2 cells. Immunol Today 2000; 19: 568-74.
13. Jankovic D, Sher A, Yap G. Th1/Th2 effector choice in parasitic infection: decision making by committee. Curr Opin Immunol 2001; 13: 403-9.
14. Kidd P. Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev 2003; 8: 223-46.
15. Sad S, Marcotte R, Mosmann TR. Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines. Immunity 1995; 2: 271-9.
16. Amel Kashipaz MR, Huggins ML, Lanyon P, Robins A, Powell RJ, Todd I. Assessment of Be1 and Be2 cells in systemic lupus erythematosus indicates elevated interleukin-10 producing CD5+ B cells. Lupus 2003; 12: 356-63.
17. Moser M, Murphy M. Dendritic cell regulation of TH1-TH2 development. Nat Immunol 2000; 1: 199-205.
18. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002; 23: 549-55.
19. Cooper MA, Fehniger TA, Caligiuri MA. The biology of human natural killer-cell subsets. Trends Immunol 2001; 22: 633-40.
20. Grossman CJ, Roselle GA, Mendenhall CL. Sex steroid regulation of autoimmunity. J Steroid Biochem Molec Biol 1991; 40: 649-59.
21. a ed. EUA: Saunders.
22. Grossman CJ, Sholiton LJ, Nathan P. Rat thymic estrogen receptor. I. Preparation, location, and physiochemical properties. J Steroid Biochem 1979; 11: 1233-40.
23. Calzolari A. Rescherches experimentales sur un rapport probable entre la function du thymus et celle des testicules. Arch Ital Biol 1898; 30: 71.
24. Chiodi H. The relationship between the thymus and the sexual organs. Endocrinol 1940; 26: 107.
25. Grossman CJ. Possible underlaying mechanism of sexual dimorphism in the immune response, fact and hypothesis. J Steroid Biochem 1989; 34: 241-51.
26. Bebo BF, Schuster JC, Vandenbark AA, Offner H. Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells. J Immunol 1999; 162: 35-40.
27. Da Silva JA. Sex hormones and glucocorticoids: interactions with the immune system. Ann N Y Acad Sci 1999; 876: 102-18.
28. Olsen NJ, Kovacs WJ. Effects of androgens on T and B lymphocyte development. Immunol Res 2001; 23(2-3): 281-8.
29. Jacobson DL, Gange SJ, Rose NR, Grahan MH. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol 1997; 84: 223-43.
30. Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev 2003; 2: 119-25.
31. Zuk M, McKean A. Sex differences in parasite infections: Patterns and processes. Int J Parasitol 1996; 26(10): 1009-23.
32. Lahita RG, Bradlow HL, Kunkel HG, Fishman J. Alterations of estrogen metabolism in SLE. Arthritis Rheum 1979; 22: 1198-1200.
33. Maret A, Coudert JD, Garidou L, Foucras G, Gourdy P, Krust A, Dupont S, Chambon P, Druet P, Bayard F, Guery JC. Estradiol enhances primary antigen-specific CD4 T cell responses and Th1 development in vivo. Essential role of estrogen receptor alpha expression in hematopoietic cells. Eur J Immunol. 2003; 33: 512-21.
34. Salem ML, Hossain MS, Nomoto K. Mediation of the immunomodulatory effect of beta-estradiol on inflammatory responses by inhibition of recruitment and activation of inflammatory cells and their gene expression of TNF-a and IFN-g. Int Arch Allergy Immunol 2000; 121: 235-45.
35. Salem ML, Matsuzaki G, Kishihara K, Madkour GA, Nomoto K. β-estradiol suppresses T cell-mediated delayed-type hypersensitivity through suppression of antigen-presenting cell function and Th1 induction. Int Arch Allergy Immunol 2000; 121: 161-9.
36. Ahmed SA, Gogal RM, Walsh JE, Saunders G. Estrogen induces defects in T cell functions of mice. FASEB J 1996; 10: 961-5.
37. Fox HS, Bond BL, Parslow TG. Estrogen regulates the IFN-γ promoter. J Immunol 1991; 146: 4362-7.
38. Gilmore W, Weiner LP, Correale J. Effect of estradiol on cytokine secretion by proteolip protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects. J Immunol 1997; 158: 446-51.
39. Correale J, Arias M, Gilmore W. Steroid hormone regulation of cytokine secretion by proteolipid protein-specific CD4+ T cell clones isolated from multiple sclerosis patients and normal control subjects. J Immunol 1998; 161: 3365-74.
40. Cutolo M. Estrogen metabolites: increasing evidence for their role in rheumatoid arthritis and systemic lupus erythematosus. J Rheumatol 2004; 31: 419-21.
41. Piccinni MP. T cell cytokines in pregnancy. Am J Reprod Immunol 2002; 47(5): 289-94.
42. Miyaura H, Iwata M. Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids. J Immunol 2002; 168: 1087-94.
43. Piccinni MP, Maggi E, Romagnani S. Role of hormone-controlled T-cell cytokines in the maintenance of pregnancy. Biochem Soc Trans 2000; 28(2): 212-15.
44. Piccini MP, Scaletti C, Maggi E, Romagnani S. Role of hormone-controlled Th1-and Th2-type cytokines in successful pregnancy. J Neuroinmunol 2000; 109: 30-3.
45. Ragusa A, de Carolis C, del Lago A, Miriello D, Ruggiero G, Brucato A, Pisoni MP, Muscara M, Merati R, Maccario L, Nobili M. Progesterone supplement in pregnancy: an immunologic therapy? Lupus 2004; 13(9): 639-42.
46. Faas M, Bouman A, Moesa H, Heineman MJ, de Leij L, Schuiling G. The immune response during the luteal phase of the ovarian cycle: a Th2-type response? Fertil Steril 2000; 74(5): 1008-13.
47. Verthelyi D, Petri M, Ylamus M, Klinman DM. Disassociation of sex hormone levels and cytokine production in SLE patients. Lupus 2001; 10(5): 352-8.
48. D'Agostino P, Milano S, Barbera C, Di Bella G, La Rosa M, Ferlazzo V, Farruggio R, Miceli DM, Miele M, Castagnetta L, Cillari E. Sex hormones modulate inflammatory mediators produced by macrophages. Ann N Y Acad Sci 1999; 876: 426-9.
49. Posma E, Moes H, Heineman MJ, Faas MM. The effect of testosterone on cytokine production in the specific and non-specific immune response. Am J Reprod Immunol 2004; 52(4): 237-43.
50. Liva SM, Voskuhl RR. Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production. J Immunol 2001; 167: 2060-7.
51. Le N, Yousefi S, Vaziri N, Carandang G, Ocariz J, Cesario T. The effect of beta-estradiol, progesterone and testosterone on the production of human leukocyte derived interferons. J Ciol Regul Homeost Agents 1988; 2(4): 199-204.
52. Wunderlich F, Dkhil MA, Mehnert LI, Braun JV, El-Khadragy M, Borsch E, Hermsen D, Benten WP, Pfeffer K, Mossmann H, Krucken J. Testosterone responsiveness of spleen and liver in female lymphotoxin beta receptor-deficient mice resistant to blood-stage malaria. Microbes Infect 2005; 7(3): 399-409.
53. Matejuk A, Hopke C, Vandenbark AA, Hum. PD, Offner H. Middle-age male mice have increased severity of experimental autoimmune encephalomyelitis and are unresponsive to testosterone therapy. J Immunol 2005; 174(4): 2387-95.
54. Muscettola M, Massai L, Lodi L, Briganti F, Fontani G, Lupo C. IFN-gamma production in rabbits: behavioral and endocrine correlates. Life Sci 2003; 72(12): 1331-43.
55. Yesilova Z, Ozata M, Kocar IH, Turan M, Pekel A, Sengul A, Ozdemir IC. The effects of gonadotropin treatment on the immunological features of male patients with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2000; 85(1): 66-70.
56. Araneo BA, Dowell T, Diegel M, Daynes RA. Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 (IL-4), IL-5, and gamma-interferon, but not IL-2 by activated murine T cells. Blood 1991; 78: 688-99.
57. Moynihan JA, Callahan TA, Kelley SP, Campbell LM. Adrenal hormone modulation of type 1 and type 2 cytokine production by spleen cells: dexamethasone and dehydroepiandrosterone suppress interleukin-2, interleukin-4, and interferon-γ production in vitro. Cell Immunol 1998; 184: 58-64.
58. Angele MK, Knoferl MW, Ayala A, Bland KI, Chaudry IH. Testosterone and estrogen differently effect Th1 and Th2 cytokine release following trauma-haemorrhage. Cytokine 2001; 16: 22-30.
59. Morales-Montor J, Baig S, Hallal-Calleros C, Damian RT. Taenia crassiceps: androgen reconstitution of the host leads to protection during cysticercosis. Exp Parasitol 2002; 100(4): 209-16.
60. Falkenstein E, Tillmann HC, Christ M, Feuring M, Wehling M. Multiple actions of steroid hormones -a focus on rapid, non-genomic effects. Pharmacol Rev 2000; 52: 513-55.
61. Bridges ED, Greenstein BD, Khamashta MA, Hughes GR. Specificity of estrogen receptors in rat thymus. Int J Immunopharmacol 1993; 15: 927-32.
62. Sakazaki H, Ueno H, Nakamuro K. Estrogen receptor alpha in mouse splenic lymphocytes: possible involvement in immunity. Toxicol Lett 2002; 133(2-3): 221-9.
63. Benten WP, Becker A, Schmitt-Wrede HP, Wunderlich F. Developmental regulation of intracellular and surface androgen receptors in T cells. Steroids 2002; 67: 925-31.
64. Auci DL, Ahlem C, Li M, Trauer R, Dowding C, Paillard F, et al. The immunobiology and therapeutic potential of androstene hormones and their synthetic derivatives: novel anti-inflammatory and immune regulating steroid hormones. Mod Asp Immunobiol 2003; 3: 64-70.
65. Polanczy MJ, Carson BD, Subramanian S, Afentoulis M, Vandenbark AA, Ziegler SF, Offner H. Cutting edge: Estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment. J Immunol 2004; 173: 2227-30.