메뉴 건너뛰기




Volumn 114, Issue 7, 2006, Pages 1083-1091

Uncoupling of ATP-mediated calcium signaling and dysregulated interleukin-6 secretion in dendritic cells by nanomolar thimerosal

Author keywords

Calcium; Calcium channel; Dendritic cell; Ethyl mercury; Immunotoxicity; Interleukin 6; Organic mercury; Redox; Thimerosal

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CALCIUM CHANNEL; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; INTERLEUKIN 6; RYANODINE; RYANODINE RECEPTOR; THIOMERSAL; TRANSCRIPTOME; UNCOUPLING PROTEIN;

EID: 33745791935     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.8881     Document Type: Article
Times cited : (26)

References (55)
  • 1
    • 0029417220 scopus 로고
    • 2+ release channel ryanodine receptor from skeletal muscle sarcoplasmic reticulum
    • 2+ release channel ryanodine receptor from skeletal muscle sarcoplasmic reticulum. J Biol Chem 270:29644-29647.
    • (1995) J Biol Chem , vol.270 , pp. 29644-29647
    • Abramson, J.J.1    Zable, A.C.2    Favero, T.G.3    Salama, G.4
  • 3
    • 0347128370 scopus 로고    scopus 로고
    • Calcium signaling through phospholipase C activates dendritic cells to mature and is necessary for the activation and maturation of dendritic cells induced by diverse agonists
    • Bagley KC, Abdelwahab SF, Tuskan RG, Lewis GK. 2004. Calcium signaling through phospholipase C activates dendritic cells to mature and is necessary for the activation and maturation of dendritic cells induced by diverse agonists. Clin Diagn Lab Immunol 11:77-82.
    • (2004) Clin Diagn Lab Immunol , vol.11 , pp. 77-82
    • Bagley, K.C.1    Abdelwahab, S.F.2    Tuskan, R.G.3    Lewis, G.K.4
  • 4
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. 1998. Dendritic cells and the control of immunity. Nature 392:245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 5
    • 0029032070 scopus 로고
    • Thapsigargin and cyclopiazonic acid initiate rapid and dramatic increases of IL-6 mRNA expression and IL-6 secretion in murine peritoneal macrophages
    • Bost KL, Mason MJ. 1995. Thapsigargin and cyclopiazonic acid initiate rapid and dramatic increases of IL-6 mRNA expression and IL-6 secretion in murine peritoneal macrophages. J Immunol 155:285-296.
    • (1995) J Immunol , vol.155 , pp. 285-296
    • Bost, K.L.1    Mason, M.J.2
  • 6
    • 0027081874 scopus 로고
    • Ryanodine stabilizes multiple conformational states of the skeletal muscle calcium release channel
    • Buck E, Zimanyi I, Abramson JJ, Pessah IN. 1992. Ryanodine stabilizes multiple conformational states of the skeletal muscle calcium release channel. J Biol Chem 267:23560-23567.
    • (1992) J Biol Chem , vol.267 , pp. 23560-23567
    • Buck, E.1    Zimanyi, I.2    Abramson, J.J.3    Pessah, I.N.4
  • 8
    • 0033538377 scopus 로고    scopus 로고
    • Notice to readers: Thimerosal in vaccines: A joint statement of the American Academy of Pediatrics and the Public Health Service
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. 1999. Notice to readers: thimerosal in vaccines: a joint statement of the American Academy of Pediatrics and the Public Health Service. MMWR Morb Mortal Wkly Rep 48(26):563-565.
    • (1999) MMWR Morb Mortal Wkly Rep , vol.48 , Issue.26 , pp. 563-565
  • 10
    • 21544478454 scopus 로고    scopus 로고
    • Differential intracellular distributions of inositol trisphosphate and ryanodine receptors within and among hematopoietic cells
    • Clark AJ, Petty HR. 2005. Differential intracellular distributions of inositol trisphosphate and ryanodine receptors within and among hematopoietic cells. J Histochem Cytochem 53:913-916.
    • (2005) J Histochem Cytochem , vol.53 , pp. 913-916
    • Clark, A.J.1    Petty, H.R.2
  • 11
    • 0006157275 scopus 로고
    • Mercurial poisoning with the fungicide Granosan M
    • Damluji S. 1962. Mercurial poisoning with the fungicide Granosan M. J Fac Med Baghdad 4:83-103.
    • (1962) J Fac Med Baghdad , vol.4 , pp. 83-103
    • Damluji, S.1
  • 13
    • 0035253835 scopus 로고    scopus 로고
    • Nucleotide receptors: An emerging family of regulatory molecules in blood cells
    • Di Virgilio F, Chiozzi P, Ferrari D, Falzoni S, Sanz JM, Morelli A, et al. 2001b. Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 97:587-600.
    • (2001) Blood , vol.97 , pp. 587-600
    • Di Virgilio, F.1    Chiozzi, P.2    Ferrari, D.3    Falzoni, S.4    Sanz, J.M.5    Morelli, A.6
  • 14
    • 0037408497 scopus 로고    scopus 로고
    • IL-6 production by pulmonary dendritic cells impedes Th1 immune responses
    • Dodge IL, Carr MW, Cernadas M, Brenner MB. 2003. IL-6 production by pulmonary dendritic cells impedes Th1 immune responses. J Immunol 170:4457-4464.
    • (2003) J Immunol , vol.170 , pp. 4457-4464
    • Dodge, I.L.1    Carr, M.W.2    Cernadas, M.3    Brenner, M.B.4
  • 15
    • 0033917137 scopus 로고    scopus 로고
    • 2+ inhibition of calcium-induced calcium release in skeletal muscle triads
    • 2+ inhibition of calcium-induced calcium release in skeletal muscle triads. Biophys J 79:279-286.
    • (2000) Biophys J , vol.79 , pp. 279-286
    • Donoso, P.1    Aracena, P.2    Hidalgo, C.3
  • 16
    • 0033669308 scopus 로고    scopus 로고
    • The P2 purinergic receptors of human dendritic cells: Identification and coupling to cytokine release
    • Ferrari D, la Sala A, Chiozzi P, Morelli A, Falzoni S, Girolomoni G, et al. 2000. The P2 purinergic receptors of human dendritic cells: identification and coupling to cytokine release. FASEB J 14:2466-2476.
    • (2000) FASEB J , vol.14 , pp. 2466-2476
    • Ferrari, D.1    la Sala, A.2    Chiozzi, P.3    Morelli, A.4    Falzoni, S.5    Girolomoni, G.6
  • 17
    • 0042707954 scopus 로고    scopus 로고
    • Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresol
    • Fessenden JD, Perez CF, Goth S, Pessah IN, Allen PD. 2003. Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresol. J Biol Chem 278:28727-28735.
    • (2003) J Biol Chem , vol.278 , pp. 28727-28735
    • Fessenden, J.D.1    Perez, C.F.2    Goth, S.3    Pessah, I.N.4    Allen, P.D.5
  • 18
    • 0034703465 scopus 로고    scopus 로고
    • Control of interleukin-18 secretion by dendritic cells: Role of calcium influxes
    • Gardella S, Andrei C, Poggi A, Zocchi MR, Rubartelli A. 2000. Control of interleukin-18 secretion by dendritic cells: role of calcium influxes. FEBS Lett 481:245-248.
    • (2000) FEBS Lett , vol.481 , pp. 245-248
    • Gardella, S.1    Andrei, C.2    Poggi, A.3    Zocchi, M.R.4    Rubartelli, A.5
  • 19
    • 33745795491 scopus 로고    scopus 로고
    • GenBank. GenBank Homepage. Available: [accessed 7 June 2006]
    • GenBank. 2006. GenBank Homepage. Available: http://www.ncbi.nlm.nih.gov/Genbank/ [accessed 7 June 2006].
    • (2006)
  • 20
    • 30844446913 scopus 로고    scopus 로고
    • Oxygen tension regulates the in vitro maturation of GM-CSF expanded murine bone marrow dendritic cells by modulating class II MHC expression
    • Goth SR, Chu RA, Pessah IN. 2006. Oxygen tension regulates the in vitro maturation of GM-CSF expanded murine bone marrow dendritic cells by modulating class II MHC expression. J Immunol Methods 308:179-191.
    • (2006) J Immunol Methods , vol.308 , pp. 179-191
    • Goth, S.R.1    Chu, R.A.2    Pessah, I.N.3
  • 21
    • 0001608030 scopus 로고    scopus 로고
    • Malignant hyperthermia
    • (Miller RD, ed). 6th ed. Philadelphia, PA:Churchill Livingstone
    • Gronert GA, Pessah IN, Muldoon SM, Tautz TJ. 2004. Malignant hyperthermia. In: Anesthesia (Miller RD, ed). 6th ed. Philadelphia, PA:Churchill Livingstone, 1033-1052.
    • (2004) Anesthesia , pp. 1033-1052
    • Gronert, G.A.1    Pessah, I.N.2    Muldoon, S.M.3    Tautz, T.J.4
  • 23
    • 21244469342 scopus 로고    scopus 로고
    • Organic mercury compounds and autoimmunity
    • Havarinasab S, Hultman P. 2005. Organic mercury compounds and autoimmunity. Autoimmun Rev 4:270-275.
    • (2005) Autoimmun Rev , vol.4 , pp. 270-275
    • Havarinasab, S.1    Hultman, P.2
  • 24
    • 33744991787 scopus 로고    scopus 로고
    • Alteration of the spontaneous systemic autoimmune disease in (NZB × NZW)F1 mice by treatment with thimerosal ethyl mercury
    • doi:10.1016/j.taap.2005.12.004 [Online 27 January 2006]
    • Havarinasab S, Hultman P. 2006. Alteration of the spontaneous systemic autoimmune disease in (NZB × NZW)F1 mice by treatment with thimerosal ethyl mercury. Toxicol Appl Pharmacol; doi:10.1016 /j.taap.2005.12.004 [Online 27 January 2006].
    • (2006) Toxicol Appl Pharmacol
    • Havarinasab, S.1    Hultman, P.2
  • 26
    • 4243086215 scopus 로고    scopus 로고
    • Neurotoxic effects of postnatal thimerosal are mouse strain dependent
    • Hornig M, Chian D, Lipkin WL. 2004. Neurotoxic effects of postnatal thimerosal are mouse strain dependent. Mol Psychiatry 9:833-845.
    • (2004) Mol Psychiatry , vol.9 , pp. 833-845
    • Hornig, M.1    Chian, D.2    Lipkin, W.L.3
  • 28
    • 0036682506 scopus 로고    scopus 로고
    • Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors
    • Idzko M, Dichmann S, Ferrari D, Di Virgilio F, la Sala A, Girolomoni G, et al. 2002. Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. Blood 100:925-932.
    • (2002) Blood , vol.100 , pp. 925-932
    • Idzko, M.1    Dichmann, S.2    Ferrari, D.3    Di Virgilio, F.4    la Sala, A.5    Girolomoni, G.6
  • 29
    • 0028151010 scopus 로고
    • Purified reconstituted inositol 1,4,5-trisphosphate receptors. Thiol reagents act directly on receptor protein
    • Kaplin AI, Ferris CD, Voglmaier SM, Snyder SH. 1994. Purified reconstituted inositol 1,4,5-trisphosphate receptors. Thiol reagents act directly on receptor protein. J Biol Chem 269:28972-28978.
    • (1994) J Biol Chem , vol.269 , pp. 28972-28978
    • Kaplin, A.I.1    Ferris, C.D.2    Voglmaier, S.M.3    Snyder, S.H.4
  • 30
    • 0035253431 scopus 로고    scopus 로고
    • Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses
    • la Sala A, Ferrari D, Corinti S, Cavani A, Di Virgilio F, Girolomoni G. 2001. Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses. J Immunol 166:1611-1617.
    • (2001) J Immunol , vol.166 , pp. 1611-1617
    • la Sala, A.1    Ferrari, D.2    Corinti, S.3    Cavani, A.4    Di Virgilio, F.5    Girolomoni, G.6
  • 31
    • 0036493389 scopus 로고    scopus 로고
    • Dendritic cells exposed to extracellular adenosine trisphosphate acquire the migratory properties of mature cells and show a reduced capacity to attract type 1 T lymphocytes
    • la Sala A, Sebastiani S, Ferrari D, Di Virgilio F, Idzko M, Norgauer J, et al. 2002. Dendritic cells exposed to extracellular adenosine trisphosphate acquire the migratory properties of mature cells and show a reduced capacity to attract type 1 T lymphocytes. Blood 99:1715-1722.
    • (2002) Blood , vol.99 , pp. 1715-1722
    • la Sala, A.1    Sebastiani, S.2    Ferrari, D.3    Di Virgilio, F.4    Idzko, M.5    Norgauer, J.6
  • 33
    • 0141457730 scopus 로고    scopus 로고
    • Mechanism of release of nucleotides and integration of their action as P2X-and P2Y-receptor activating molecules
    • Lazarowski ER, Boucher RC, Harden TK. 2003. Mechanism of release of nucleotides and integration of their action as P2X-and P2Y-receptor activating molecules. Mol Pharmacol 64:785-795.
    • (2003) Mol Pharmacol , vol.64 , pp. 785-795
    • Lazarowski, E.R.1    Boucher, R.C.2    Harden, T.K.3
  • 34
    • 0028567151 scopus 로고
    • Molecular interaction between ryanodine receptor and glycoprotein triadin involves redox cycling of functionally important hyperreactive sulfhydryls
    • Liu G, Pessah IN. 1994. Molecular interaction between ryanodine receptor and glycoprotein triadin involves redox cycling of functionally important hyperreactive sulfhydryls. J Biol Chem 269:33028-33034.
    • (1994) J Biol Chem , vol.269 , pp. 33028-33034
    • Liu, G.1    Pessah, I.N.2
  • 35
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • Lutz MB, Kukutsch N, Ogilvie AL, Rossner S, Koch F, Romani N, et al. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 223:77-92.
    • (1999) J Immunol Methods , vol.223 , pp. 77-92
    • Lutz, M.B.1    Kukutsch, N.2    Ogilvie, A.L.3    Rossner, S.4    Koch, F.5    Romani, N.6
  • 37
    • 0036772856 scopus 로고    scopus 로고
    • IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension
    • Murata Y, Ohteki T, Koyasu S, Hamuro J. 2002. IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension. Eur J Immunol 32:2866-2873.
    • (2002) Eur J Immunol , vol.32 , pp. 2866-2873
    • Murata, Y.1    Ohteki, T.2    Koyasu, S.3    Hamuro, J.4
  • 38
    • 0036431675 scopus 로고    scopus 로고
    • A reducing microenvironment leads to the generation of FcepsilonRIhigh inflammatory dendritic epidermal cells (IDEC)
    • Novak N, Kraft S, Haberstok J, Geiger E, Allam P, Bieber T. 2002. A reducing microenvironment leads to the generation of FcepsilonRIhigh inflammatory dendritic epidermal cells (IDEC). J Invest Dermatol 119:842-849.
    • (2002) J Invest Dermatol , vol.119 , pp. 842-849
    • Novak, N.1    Kraft, S.2    Haberstok, J.3    Geiger, E.4    Allam, P.5    Bieber, T.6
  • 39
    • 0037070183 scopus 로고    scopus 로고
    • Identification of functional type 1 ryanodine receptors in mouse dendritic cells
    • O'Connell PJ, Klyachko VA, Ahern GP. 2002. Identification of functional type 1 ryanodine receptors in mouse dendritic cells. FEBS Lett 512:67-70.
    • (2002) FEBS Lett , vol.512 , pp. 67-70
    • O'Connell, P.J.1    Klyachko, V.A.2    Ahern, G.P.3
  • 40
    • 12144285678 scopus 로고    scopus 로고
    • Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: Impact on the development of humoral immunity
    • Partida-Sanchez S, Goodrich S, Kusser K, Oppenheimer N, Randall TD, Lund FE. 2004. Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity. Immunity 20:279-291.
    • (2004) Immunity , vol.20 , pp. 279-291
    • Partida-Sanchez, S.1    Goodrich, S.2    Kusser, K.3    Oppenheimer, N.4    Randall, T.D.5    Lund, F.E.6
  • 41
    • 0036583321 scopus 로고    scopus 로고
    • Redox sensing properties of the ryanodine receptor complex
    • Pessah IN, Kim KH, Feng W. 2002. Redox sensing properties of the ryanodine receptor complex. Front Biosci 7:a72-79.
    • (2002) Front Biosci , vol.7
    • Pessah, I.N.1    Kim, K.H.2    Feng, W.3
  • 43
    • 0032571244 scopus 로고    scopus 로고
    • Involvement of dihydropyridine-sensitive calcium channels in human dendritic cell function. Competition by HIV-1 Tat
    • Poggi A, Rubartelli A, Zocchi MR. 1998. Involvement of dihydropyridine-sensitive calcium channels in human dendritic cell function. Competition by HIV-1 Tat. J Biol Chem 273:7205-7209.
    • (1998) J Biol Chem , vol.273 , pp. 7205-7209
    • Poggi, A.1    Rubartelli, A.2    Zocchi, M.R.3
  • 44
    • 0037379708 scopus 로고    scopus 로고
    • Kinetic studies of calcium-induced calcium release in cardiac sarcoplasmic reticulum vesicles
    • Sanchez G, Hidalgo C, Donoso P. 2003. Kinetic studies of calcium-induced calcium release in cardiac sarcoplasmic reticulum vesicles. Biophys J 84:2319-2330.
    • (2003) Biophys J , vol.84 , pp. 2319-2330
    • Sanchez, G.1    Hidalgo, C.2    Donoso, P.3
  • 46
    • 1442357027 scopus 로고    scopus 로고
    • CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2
    • Scandella E, Men Y, Legler DF, Gillessen S, Prikler L, Ludewig B, et al. 2004. CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. Blood 103:1595-1601.
    • (2004) Blood , vol.103 , pp. 1595-1601
    • Scandella, E.1    Men, Y.2    Legler, D.F.3    Gillessen, S.4    Prikler, L.5    Ludewig, B.6
  • 47
    • 0034667802 scopus 로고    scopus 로고
    • Extracellular ATP and TNF-α synergize in the activation and maturation of human dendritic cells
    • Schnurr M, Then F, Galambos P, Scholz C, Siegmund B, Endres S, et al. 2001 Extracellular ATP and TNF-α synergize in the activation and maturation of human dendritic cells. J Immunol 165:4704-4709.
    • (2001) J Immunol , vol.165 , pp. 4704-4709
    • Schnurr, M.1    Then, F.2    Galambos, P.3    Scholz, C.4    Siegmund, B.5    Endres, S.6
  • 48
    • 0038156223 scopus 로고    scopus 로고
    • ATP gradients inhibit the migratory capacity of specific human dendritic cell types: Implications for P2Y11 receptor signaling
    • Schnurr M, Toy T, Stoitzner P, Cameron P, Shin A, Beecroft T, et al. 2003. ATP gradients inhibit the migratory capacity of specific human dendritic cell types: implications for P2Y11 receptor signaling. Blood 102:613-620.
    • (2003) Blood , vol.102 , pp. 613-620
    • Schnurr, M.1    Toy, T.2    Stoitzner, P.3    Cameron, P.4    Shin, A.5    Beecroft, T.6
  • 49
    • 0034814542 scopus 로고    scopus 로고
    • Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5
    • Shigemoto-Mogami Y, Koizumi S, Tsuda M, Ohsawa K, Kohsaka S, Inoue K. 2001. Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. J Neurochem 78:1339-1349.
    • (2001) J Neurochem , vol.78 , pp. 1339-1349
    • Shigemoto-Mogami, Y.1    Koizumi, S.2    Tsuda, M.3    Ohsawa, K.4    Kohsaka, S.5    Inoue, K.6
  • 50
    • 24644512474 scopus 로고    scopus 로고
    • Mercury and autoimmunity: Implications for occupational and environmental health
    • Silbergeld EK, Silva IA, Nyland JF. 2005. Mercury and autoimmunity: implications for occupational and environmental health. Toxicol Appl Pharmacol 207:S282-S292.
    • (2005) Toxicol Appl Pharmacol , vol.207
    • Silbergeld, E.K.1    Silva, I.A.2    Nyland, J.F.3
  • 52
    • 0036019581 scopus 로고    scopus 로고
    • JAK/STAT pathways are not involved in the direct activation of antigen-presenting cells by contact sensitizers
    • Valk E, Zahn S, Knop J, Becker D. 2002. JAK/STAT pathways are not involved in the direct activation of antigen-presenting cells by contact sensitizers. Arch Dermatol Res 294:163-167.
    • (2002) Arch Dermatol Res , vol.294 , pp. 163-167
    • Valk, E.1    Zahn, S.2    Knop, J.3    Becker, D.4
  • 53
    • 4544354842 scopus 로고    scopus 로고
    • Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry
    • Voss AA, Lango J, Ernst-Russell M, Morin D, Pessah IN. 2004. Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry. J Biol Chem 279:34514-34520.
    • (2004) J Biol Chem , vol.279 , pp. 34514-34520
    • Voss, A.A.1    Lango, J.2    Ernst-Russell, M.3    Morin, D.4    Pessah, I.N.5
  • 54
    • 0021362207 scopus 로고
    • Clinical observations in ethyl mercury chloride poisoning
    • Zhang J. 1984. Clinical observations in ethyl mercury chloride poisoning. Am J Indust Med 5:251-258.
    • (1984) Am J Indust Med , vol.5 , pp. 251-258
    • Zhang, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.