β-sheet is the bioactive conformation of the anti-angiogenic anginex peptide

Biochemical Journal

Volumn 373, Issue 1, 2003, Pages 281-288

  Dings, Ruud P M ^a,b   Arroyo, Monica M ^a   Lockwood, Nathan A ^a   Van Eijk, Loes I ^b   Haseman, Judy R ^a   Griffioen, Arjan W ^b   Mayo, Kevin H ^a  

^a University of Minnesota   (United States)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apoptosis; Disulphides; Endothelial cell proliferation; NMR; Peptide; Structure

Indexed keywords

CELLS; NUCLEAR MAGNETIC RESONANCE;

BIOACTIVE CONFORMATION;

PROTEINS;

ANGINEX; ANGIOGENESIS INHIBITOR; CYSTEINE DERIVATIVE; CYSTEINE DISULFIDE; PEPTIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BETA SHEET; CELL PROLIFERATION; CELL SURFACE; CIRCULAR DICHROISM; CONTROLLED STUDY; DISULFIDE BOND; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANGIOGENESIS INHIBITORS; CELL DIVISION; CELLS, CULTURED; CIRCULAR DICHROISM; ENDOTHELIUM, VASCULAR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN STRUCTURE, SECONDARY; PROTEINS;

EID: 0038343115     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030295     Document Type: Article

References (34)

1. Folkman, J. (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1, 27-31
2. Griffioen, A. W. and Molema, G. (2000) Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol. Rev. 52, 237-268
3. Gupta, S. K. and Singh, J. P. (1994) Inhibition of endothelial cell proliferation by platelet factor-4 involves a unique action on S phase progression. J. Cell Biol. 127, 1121-1127
4. Rastinejad, F., Polverini, P. J. and Bouck, N. P. (1989) Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene. Cell (Cambridge, Mass.) 56, 345-355
5. O'Reilly, M. S., Holmgren, L., Shing, Y., Chen, C., Rosenthal, R. A., Moses, M., Lane, W. S., Cao, Y., Sage, E. H. and Folkman, J. (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell (Cambridge, Mass.) 79, 315-328
6. O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R. and Folkman, J. (1997) Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell (Cambridge, Mass.) 88, 277-285
7. van der Schaft, D. W., Toebes, E. A., Haseman, J. R., Mayo, K. H. and Griffioen, A. W. (2000) Bactericidal/permeability-increasing protein (BPI) inhibits angiogenesis via induction of apoptosis in vascular endothelial cells. Blood 96, 176-181
8. Griffioen, A. W., van der Schaft, D. W., Barendsz-Janson, A. F., Cox, A., Struijker Boudier, H. A., Hillen, H. F. and Mayo, K. H. (2001) Anginex, a designed peptide that inhibits angiogenesis. Biochem. J. 354, 233-242
9. Mayo, K. H., van der Schaft, D. W. and Griffioen, A. W. (2001) Designed β-sheet peptides that inhibit proliferation and induce apoptosis in endothelial cells. Angiogenesis 4, 45-51
10. Mayo, K. H., Ilyina, E. and Park, H. (1996) A recipe for designing water-soluble, β-sheet-forming peptides. Protein Sci. 5, 13001-11315
11. Ilyina, E., Roongta, V. and Mayo, K. H. (1997) NMR structure of a de novo designed, peptide 33mer with two distinct, compact β-sheet folds. Biochemistry 36, 5245-5250
12. Mayo, K. H., Haseman, J. R., Ilyina, E. and Gray, B. (1998) Designed β-sheet-forming peptide 33mers with potent human bactericidal/permeability increasing protein-like bactericidal and endotoxin neutralizing activities. Biochim. Biophys. Acta 1425, 81-92
13. van der Schaft, D. W., Dings, R. P., de Lussanet, Q. G., van Eijk, L. I., Nap, A. W., Beets-Tan, R. G., Bouma-Ter Steege, J. C., Wagstaff, J., Mayo, K. H. and Griffioen, A. W. (2002) The designer anti-angiogenic peptide anginex targets tumor endothelial cells and inhibits tumor growth in animal models. FASEB J. 16, 1991-1993
14. Dings, R. P., Yokoyama, Y., Ramakrishnan, S., Griffioen, A. W. and Mayo, K. H. (2003) The designed angiostatic peptide anginex synergistically improves chemotherapy and antiangiogenesis therapy with angiostatin. Cancer Res. 63, 382-385
15. Dings, R. P. M., van der Schaft, D. W., Hargittai, B., Haseman, J. R., Griffioen, A. W. and Mayo, K. H. (2003) Anti-tumor activity of the novel angiogenesis inhibitor anginex. Cancer Lett. (Shannon, Irel.) 194, 55-66
16. Adler, A. J., Greenfield, N. J. and Fasman, G. D. (1973) Circular dichroism and optical rotary dispersion of proteins and polypeptides. Methods Enzymol. 27, 675-735
17. Greenfield, N. and Fasman, G. D. (1969) Computed circular dichroism spectra for the evaluation of protein conformation. Biochemistry. 8, 4108-4116
18. Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J. and Bax, A. (1995) NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J. Biomol. NMR. 6, 277-293
19. Brunger, A. T. (1992) X-plor Manual, Yale University Press, New Haven
20. Mayo, K. H., Haseman, J., Young, H. C. and Mayo, J. W. (2000) Structure-function relationships in novel peptide dodecamers with broad-spectrum bactericidal and endotoxin-neutralizing activities. Biochem. J. 349, 717-728
21. Guex, N. and Peitsch, M. C. (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18, 2714-2723
22. Relou, I. A., Damen, C. A., van der Schaft, D. W., Groenewegen, G. and Griffioen, A. W. (1998) Effect of culture conditions on endothelial cell growth and responsiveness. Tissue Cell 30, 525-530
23. Darzynkiewicz, Z., Bruno, S., Del Bino, G., Gorczyca, W., Hotz, M. A., Lassota, P. and Traganos, F. (1992) Features of apoptotic cells measured by flow cytometry. Cytometry 13, 795-808
24. van der Schaft, D. W., Wagstaff, J., Mayo, K. H. and Griffioen, A. W. (2002) The antiangiogenic properties of bactericidal/permeability-increasing protein (BPI). Ann. Med. 34, 19-27
25. Wild, R., Ramakrishnan, S., Sedgewick, J. and Griffioen, A. W. (2000) Quantitative assessment of angiogenesis and tumor vessel architecture by computer-assisted digital image analysis: effects of VEGF-toxin conjugate on tumor microvessel density. Microvasc. Res. 59, 368-376
26. Johnson, W. C. J. (1990) Protein secondary structure and circular dichroism: a practical guide. Proteins 7, 205-214
27. Waterhous, D. V. and Johnson, Jr, W. C. (1994) Importance of environment in determining secondary structure in proteins. Biochemistry 33, 2121-2128
28. Hanzawa, H., Shimada, I., Kuzuhara, T., Komano, H., Kohda, D., Inagaki, F., Natori, S. and Arata, Y. (1990) 1H nuclear magnetic resonance study of the solution conformation of an antibacterial protein, sapecin. FEBS Lett. 269, 413-420
29. Selsted, M. E. and Harwig, S. S. (1989) Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide. J. Biol. Chem. 264, 4003-4007
30. Bodenhausen, G., Vold, R. L. and Vold, R. R. (1980) Multiple quantum spin echo spectroscopy. J. Magn. Reson. 37, 93-99
31. Hohenester, E., Sasaki, T., Olsen, B. R. and Timpl, R. (1998) Crystal structure of the angiogenesis inhibitor endostatin at 1.5 Å resolution. EMBO J. 17, 1656-1664
32. Mayo, K. H., Roongta, V., Ilyina, E., Milius, R., Barker, S., Quinlan, C., La Rosa, G. and Daly, T. J. (1995) NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer. Biochemistry 34, 11399-11409
33. Baeyens, K. J., De Bondt, H. L., Raeymaekers, A., Fiers, W. and De Ranter, C. J. (1999) The structure of mouse tumour-necrosis factor at 1.4 Å resolution: towards modulation of its selectivity and trimerization. Acta Crystallogr., Sect. D: Biol. Crystallogr. 55, 772-778
34. Beamer, L. J., Carroll, S. F. and Eisenberg, D. (1997) Crystal structure of human BPI and two bound phospholipids at 2.4 Å resolution. Science (Washington, D.C.) 276, 1861-1864