Kidney plays a major role in ammonia homeostasis after portasystemic shunting in patients with cirrhosis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 291, Issue 2, 2006, Pages

  Olde Damink, Steven W M ^a,b,d   Dejong, Cornelis H C ^a,b   Deutz, Nicolaas E P ^a   Redhead, Doris N ^b   Hayes, Peter C ^b   Soeters, Peter B ^a   Jalan, Rajiv ^b,c  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^d MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cirrhosis

Indexed keywords

AMMONIA;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FEMORAL VEIN; HEPATIC VEIN; HOMEOSTASIS; HUMAN; KIDNEY FUNCTION; KIDNEY PLASMA FLOW; KIDNEY VEIN; LEG MUSCLE; LIVER BLOOD FLOW; LIVER CIRRHOSIS; MALE; PORTAL VEIN; PORTOSYSTEMIC ANASTOMOSIS; PRIORITY JOURNAL; SPLANCHNIC BLOOD FLOW;

ADAPTATION, PHYSIOLOGICAL; AMMONIA; FEMALE; FIBROSIS; HOMEOSTASIS; HUMANS; KIDNEY; MALE; MIDDLE AGED; MUSCLE, SKELETAL; PORTASYSTEMIC SHUNT, TRANSJUGULAR INTRAHEPATIC;

EID: 33745765238     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00165.2005     Document Type: Article

References (26)

1. Attmane-Elakeb A, Amlal H, and Bichara M. Ammonium carriers in medullary thick ascending limb. Am J Physiol Renal Physiol 280: F1-F9, 2001.
2. Azoulay D, Castaing D, Dennison A, Martino W, Eyraud D, and Bismuth H. Transjugular intrahepatic portosystemic shunt worsens the hyperdynamic circulatory state of the cirrhotic patient: preliminary report of a prospective study. Hepatology 19: 129-132, 1994.
3. Clemmesen JO, Tygstrup N, and Ott P. Hepatic plasma flow estimated according to Fick's principle in patients with hepatic encephalopathy: evaluation of indocyanine green and D- sorbitol as test substances. Hepatology 27: 666-673, 1998.
4. Clemmesen JO, Larsen FS, Kondrup J, Hansen BA, and Ott P. Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology 29: 648-653, 1999.
5. Clemmesen JO, Kondrup J, and Ott P. Splanchnic and leg exchange of amino acids and ammonia in acute liver failure. Gastroenterology 118: 1131-1139, 2000.
6. Cooper AJ and Plum F. Biochemistry and physiology of brain ammonia. Physiol Rev 67: 440-519, 1987.
7. Debatin JF, Zahner B, Meyenberger C, Romanowski B, Schopke W, Marincek B, and Fuchs WA. Azygos blood flow: phase contrast quantitation in volunteers and patients with portal hypertension pre- and postintrahepatic shunt placement. Hepatology 24: 1109-1115, 1996.
8. Dejong CHC, Kampman MT, Deutz NEP, and Soeters PB. Altered glutamine metabolism in rat portal drained viscera and hindquarter during hyperammonemia. Gastroenterology 102: 936-948, 1992.
9. Dejong CH, Deutz NE, and Soeters PB. Metabolic adaptation of the kidney to hyperammonemia during chronic liver insufficiency in the rat. Hepatology 18: 890-902, 1993.
10. Dejong CHC, Deutz NEP, and Soeters PB. Renal ammonia and glutamine metabolism during liver insufficiency-induced hyperammonemia in the rat. J Clin Invest 92: 2834-2840, 1993.
11. van Eijk HM, Rooyakkers DR, Soeters PB, and Deutz NE. Determination of amino acid isotope enrichment using liquid chromatography-mass spectrometry. Anal Biochem 271: 8-17, 1999.
12. Halperin ML, Kamel KS, Ethier JH, Stinebaugh BJ, and Jungas RL. Biochemistry and Physiology of ammonium excretion. In: The Kidney: Physiology and Pathophysiology, edited by Seldin DW and Giebisch G. New York: Raven, 1992 Chapt. 76, p. 2645-2679.
13. Jalan R, Plevris JN, Jalan AR, Finlayson ND, and Hayes PC. A pilot study of indocyanine green clearance as an early predictor of graft function. Transplantation 58: 196-200, 1999.
14. Jalan R, Dabos K, Redhead DN, Lee A, and Hayes PC. Elevation of intracranial pressure following transjugular intrahepatic portosystemic stent-shunt for variceal haemorrhage. J Hepatol 27: 928-933, 1997.
15. Jalan R and Hayes PC. Hepatic encephalopathy and ascites. Lancet 350: 1309-1315, 1997.
16. Jalan R, Newby DE, Olde Damink SWM, Redhead DN, Hayes PC, and Lee A. Acute changes in cerebral blood flow and metabolism during portasystemic shunting. Liver Transpl 7: 274-278, 2001.
17. Jalan R and Kapoor D. Enhanced renal ammonia excretion following volume expansion in patients with well compensated cirrhosis of the liver. Gut 52: 1041-1045, 2003.
18. + in relation to the control of acid-base balance by the kidney. J Nephrol 15, Suppl 5: S128-S134, 2002.
19. Lotterer E, Wengert A, and Fleig WE. Transjugular intrahepatic portosystemic shunt: short-term and long-term effects on hepatic and systemic hemodynamics in patients with cirrhosis. Hepatology 29: 632-639, 1999.
20. Nath KA, Salahudeen AK, Clark EC, Hostetter MK, and Hostetter TH. Role of cellular metabolites in progressive renal injury. Kidney Int Suppl 38: S109-S113, 1992.
21. Olde Damink SWM, Jalan R, Redhead DN, Hayes PC, Deutz NEP, and Soeters PB. Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS. Hepatology 36: 1163-1171, 2002.
22. Olde Damink SW, Jalan R, Deutz NE, Redhead DN, Dejong CH, Hynds P, Jalan RA, Hayes PC, and Soeters PB. The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis. Hepatology 37: 1277-1285, 2003.
23. Selkurt EE. Measurement of renal blood flow. Meth Med Res 1: 191-199, 1948.
24. Uusaro A, Ruokonen E, and Takala J. Estimation of splanchnic blood flow by the Fick principle in man and problems in the use of indocyanine green. Cardiovasc Res 30: 106-112, 1995.
25. Vinay P, Allignet E, Pichette C, Watford M, Lemieux G, and Gougoux A. Changes in renal metabolite profile and ammoniagenesis during acute and chronic metabolic acidosis in dog and rat. Kidney Int 7: 312-325, 1980.
26. Welbourne TC, Childress D, and Givens G. Renal regulation of interorgan glutamine flow in metabolic acidosis. Am J Physiol Regul Integr Comp Physiol 251: R858-R866, 1986.