The dynamics of estrogen receptor activity

Maturitas

Volumn 54, Issue 4, 2006, Pages 315-320

  Ciana, P ^a   Scarlatti, F ^a   Biserni, A ^a   Ottobrini, L ^a   Brena, A ^a   Lana, A ^a   Zagari, F ^a   Lucignani, G ^a   Maggi, A ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Bioluminescence; Drug evaluation; Estrogen receptors; Insulators; Intracellular receptors; Luciferase; Molecular imaging; Pre clinical animal models; SERMs; Transgenic mice

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ARTICLE; CLINICAL RESEARCH; ESTROGEN ACTIVITY; ESTROGEN RESPONSIVE ELEMENT; ESTROGEN SYNTHESIS; ESTROGEN THERAPY; ESTRUS CYCLE; IMAGE ANALYSIS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; OPTICAL DENSITY; POSTMENOPAUSE; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR SENSITIVITY; REPORTER GENE; SIGNAL TRANSDUCTION; SPECIES COMPARISON;

ANIMALS; FEMALE; GENES, REPORTER; LUCIFERASES; MICE; MODELS, ANIMAL; RECEPTORS, ESTROGEN;

ANIMALIA;

EID: 33745727881     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2006.04.016     Document Type: Article

References (27)

1. Wenger NK, Paoletti R, editors. International position paper on women's health and menopause: a comprehensive approach. NIH publication no. 02-3284, Bethesda, MD; 2002. p. 1-23.
2. Maggi A., Ciana P., Belcredito S., and Vegeto E. Estrogen in nervous system: mechanisms in non reproductive functions. Annu Rev Physiol 66 (2004) 291-313
3. Power R.F., Mani S.K., Codina J., Conneely O.M., and O'Malley B.W. Dopaminergic and ligand-independent activation of steroid hormone receptors. Science 254 (1991) 1636-1639
4. Ma Z.Q., Spreafico E., Pollio G., et al. Activated estrogen receptor mediates growth arrest and differentiation of a neuroblastoma cell line. Proc Natl Acad Sci USA 90 (1993) 3740-3744
5. Kato S., Endoh H., Masuhiro Y., et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270 (1995) 1491-1494
6. Bunone G., Briand P.A., Miksicek R.J., and Picard D. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J 15 (1996) 2174-2183
7. Patrone C., Ma Z.Q., Pollio G., Agrati P., Parker M.G., and Maggi A. Cross-coupling between insulin and estrogen receptor in human neuroblastoma cells. Mol Endocrinol 10 (1996) 499-507
8. Stein B., and Yang M.X. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol Cell Biol 15 (1995) 4971-4979
9. Webb P., Lopez G.N., Uht R.M., and Kushner P.J. Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens. Mol Endocrinol 9 (1995) 443-456
10. Paech K., Webb P., Kuiper G.G., et al. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 277 (1997) 1508-1510
11. Bjornstrom L., and Sjoberg M. Signal transducers and activators of transcription as downstream targets of nongenomic estrogen receptor actions. Mol Endocrinol 16 (2002) 2202-2214
12. Ciana P., Ghisletti S., Mussi P., Eberini I., Vegeto E., and Maggi A. ERalpha a molecular switch converting TGFalpha-mediated proliferation into differentiation in neuroblastoma cells. J Biol Chem 278 (2003) 31737-31744
13. Vegeto E., Belcredito S., Etteri S., et al. Estrogen receptor-alpha mediates the inhibitory activity of estradiol on brain macrohage reactivity. Proc Natl Acad Sci USA 100 (2003) 9614-9619
14. Migliaccio A., Di Domenico M., Castoria G., et al. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J 15 (1996) 1292-1300
15. Simoncini T., Hafezi-Moghadam A., Brazil D.P., Ley K., Chin W.W., and Liao J.K. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature 407 (2000) 538-541
16. Wade C.B., Robinson S., Shapiro R.A., and Dorsa D.M. Estrogen receptor (ER)alpha and ERbeta exhibit unique pharmacologic properties when coupled to activation of the mitogen-activated protein kinase pathway. Endocrinology 142 (2001) 2336-2442
17. Riggs B.L., and Hartmann L.C. Selective estrogen-receptor modulators-mechanisms of action and application to clinical practice. N Engl J Med 348 (2003) 618-629
18. Maggi A., Ottobrini L., Biserni A., Lucignani G., and Ciana P. Techniques: reporter mice-a new way to look at drug action. Trends Pharmacol Sci 25 (2004) 337-342
19. Maggi A., and Ciana P. Reporter mice and drug discovery and development. Nat Rev Drug Discov 4 (2005) 249-255
20. Ciana P., Di Luccio G., Belcredito S., et al. Engineering of a mouse for the in vivo profiling of estrogen receptor activity. Mol Endocrinol 15 (2001) 1104-1113
21. Di Lorenzo D., Villa R., Biasiotto G., et al. Isomer-specific activity of dichlorodyphenyltrichloroethane with estrogen receptor in adult and suckling estrogen reporter mice. Endocrinology 143 (2002) 4544-4551
22. Klotz D.M., Hewitt S.C., Ciana P., et al. Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. J Biol Chem 8 (2002) 8531-8537
23. Patrone C., Tobias N., Cassel T.N., et al. Estrogen regulates lung homeostasis via estrogen receptor α. Mol Cell Biol 23 (2003) 8542-8552
24. Ciana P., Raviscioni M., Mussi P., et al. In vivo imaging of transcriptionally active estrogen receptors. Nat Med 9 (2003) 82-86
25. Ciana P., Mussi P., Raviscioni M., et al. The ERE-luc reporter mouse. Ernst Schering Res Found Workshop 46 (2004) 151-168
26. Massoud T.F., and Gambhir S.S. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 17 (2003) 545-580
27. Rossouw J.E., Anderson G.L., Prentice R.L., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. JAMA 288 (2002) 321-333