Contactless magnetocardiographic mapping in anesthetized Wistar rats: Evidence of age-related changes of cardiac electrical activity

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 291, Issue 1, 2006, Pages

  Brisinda, Donatella ^a   Caristo, Maria Emiliana ^a   Fenici, Riccardo ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Aging; Cardiac mapping; Magnetocardiography; Sex; Ventricular repolarization

Indexed keywords

AGING; ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; DATA BASE; DIPOLE; ELECTROCARDIOGRAM; FEMALE; HEART ATRIUM; HEART ELECTROPHYSIOLOGY; HEART REPOLARIZATION; HEART VENTRICLE; IMAGING SYSTEM; MAGNETOCARDIOGRAPHY; MALE; NONHUMAN; PR INTERVAL; PRIORITY JOURNAL; QRS COMPLEX; QT INTERVAL; RAT; RR INTERVAL; SIGNAL NOISE RATIO;

ADAPTATION, PHYSIOLOGICAL; AGING; ANESTHESIA; ANIMALS; BODY SURFACE POTENTIAL MAPPING; DATABASES, FACTUAL; ELECTROCARDIOGRAPHY; ELECTRODES; EVIDENCE-BASED MEDICINE; FEMALE; HEART CONDUCTION SYSTEM; ITALY; MAGNETICS; MALE; RATS; RATS, WISTAR; REFERENCE VALUES;

EID: 33745712645     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01048.2005     Document Type: Article

References (77)

1. Achenbach S, Moshage W, and Bachmann K. Magnetocardiography: clinical investigations with a biomagnetic multichannel system. Physiol Meas 14: 61-68, 1993.
2. Aiba T, Inagaki M, Shimizu W, Matsuo K, Taguchi A, Suyama K, Kurita T, Aihara N, Sunagawa K, and Kamakura S. Recovery time dispersion measured from 87-lead body surface potential mapping as a predictor of sustained ventricular tachycardia in patients with idiopathic dilated cardiomyopathy. J Cardiovasc Electrophysiol 11: 968-974, 2000.
3. Aimi B, Stilli D, Sgoifo A, Manghi M, and Musso E. Effects of aging on cardiac electrical activity in a rat model. A longitudinal study. In: Electrocardiology 92, edited by McFarlane PW and de Padua F. Lisbon, Portugal: World Scientific, 1992.
4. Andrade Lima E, Hall Barbosa C, Costa Monteiro E, Marchesin D, and Haueisen J. Analysis of a secondary activity during reentry propagation in rabbit atrial tissue. In: Proceedings of the 13th International Conference on Biomagnetism, edited by Nowak H, Haueisen J, Giebler F, and Huonker R. Berlin: VDE Verlag, 2002.
5. Antzelevitch C. Cellular basis and mechanism underlying normal and abnormal myocardial repolarization and arrhythmogenesis. Ann Med 36 Suppl 1: 5-14, 2004.
6. Baillard C, Mansier P, Ennezat PV, Mangin L, Medigue C, Swynghedauw B, and Chevalier B. Converting enzyme inhibition normalizes QT interval in spontaneously hypertensive rats. Hypertension 36: 350-354, 2000.
7. Baker LC, London B, Choi BR, Koren G, and Salama G. Enhanced dispersion of repolarization and refractoriness in transgenic mouse hearts promotes reentrant ventricular tachycardia. Circ Res 86: 396-407, 2000.
8. Bernadic M and Zlatos L. Cardioelectrical field in experimental cardiomegaly in rats. Bratisl Lek Listy 97: 543-549, 1996.
9. Berul CI, Aronovitz MJ, Wang PJ, and Mendelsohn ME. In vivo cardiac electrophysiology studies in the mouse. Circulation 94: 2641-2648, 1996.
10. Bidoggia H, Maciel JP, Capalozza N, Mosca S, Blaksley EJ, Valverde E, Bertran G, Arini P, Biagetti MO, and Quinteiro RA. Sex differences on the electrocardiographic pattern of cardiac repolarization. Possible role of testosterone. Am Heart J 140: 678-683, 2000.
11. Brisinda D, Fenici R, Meloni AM, and Fenici P. Unshielded multichannel magnetocardiographic mapping of small animals. Biomed Tech (Berl) 48: 162-164, 2004.
12. Brisinda D, Meloni AM, and Fenici R. Magnetocardiographic differences of ventricular repolarization parameters between Wistar rats and guinea pigs. Neurol Clin Neurophysiol 2004: 9, 2004.
13. Brisinda D, Meloni AM, and Fenici R. Contactless magnetocardiographic study of ventricular repolarization in intact Wistar rats: evidence of gender-related differences. Basic Res Cardiol 99: 193-203, 2004.
14. Brisinda D, Meloni AM, Fenici P, and Fenici R. Unshielded multichannel magnetocardiographic study of ventricular repolarization in healthy subjects. Biomed Tech (Berl) 48: 165-167, 2004.
15. Brisinda D, Meloni AM, and Fenici R. First 36-channel magnetocardiographic study of CAD patients in an unshielded laboratory for interventional and intensive cardiac care. Lecture Note Comp Sci 2674: 122-131, 2003.
16. Brisinda D, Comani S, Meloni AM, Alleva G, Mantini D, and Fenici R. Multichannel mapping of fetal magnetocardiogram in an unshielded hospital setting. Prenat Diagn 25: 376-382, 2005.
17. Burke JH, Goldberger JJ, Ehlert FA, Kruse JT, Parker MA, and Kadish AH. Gender-related differences in heart rate before and after autonomic blockade: evidence against and intrinsic gender effect. Am J Med 100: 537-543, 1996.
18. Ks channel expression in adult murine heart. Am J Physiol Heart Circ Physiol 284: H168-H175, 2003.
19. Cohen I, Giles W, and Noble D. Cellular bases for the T wave of the electrocardiogram. Nature 262: 657-661, 1976.
20. Cohen D, Edelsack EA, and Zimmermann JE. Magnetocardiograms taken in a shielded room with a superconducting point-contact magnetometer. Appl Phys Lett 16: 278-280, 1970.
21. Committee for Proprietary Medicinal Products. Points to Consider: The Assessment of the Potential for QT Interval Prolongation by Non-Cardiovascular Medicinal Products. London: Committee for Proprietary Medicinal Products, 1997. (Rep. CPMP/987/96)
22. Costa Monteiro E, Hall Barbosa C, Andrade Lima E, Eiselt M, Gieâler F, and Haueisen J. Experimental detection of reflected reentry propagation in rabbit atrial tissue using a multi-channel SQUID system. In: Proceedings of 13th International Conference on Biomagnetism, edited by Nowak H, Haueisen J, Giessler F, and Huonker R. Berlin: VDE Verlag, 2002.
23. Costa Monteiro E, Barbosa CH, Eiselt M, Giessler F, Flemming L, and Haueisen J. Magnetic imaging of electrical propagation at the apex of isolated rabbit heart. Biomed Tech (Berl) 48: 168-170, 2004.
24. Danik S, Cabo C, Chiello C, Kang S, Wit AL, and Coromilas J. Correlation of repolarization of ventricular monophasic action potential with ECG in the murine heart. Am J Physiol Heart Circ Physiol 283: H372-H381, 2002.
25. Dias da Silva VJ, Ferreira Neto E, Salgado HC, and Fazan R Jr. Chronic converting enzyme inhibition normalizes QT interval in aging rats. Braz J Med Biol Res 35: 1025-1031, 2002.
26. Dritsas A, Sbarouni E, Gilligan D, Nihoyannopoulos P, and Oakley CM. QT interval abnormalities in hypertrophic cardiomyopathy. Clin Cardiol 15: 739-742, 1992.
27. FDA/Health Canada. Preliminary concept paper: The clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for nonantiarrhythmic drugs [Online]. FDA/Health Canada. http://www.fda.gov/cder/calendar/meeting/ qt4jam.pdf [2002].
28. Fenici R, Brisinda D, Nenonen J, and Fenici P. Phantom validation of multichannel magnetocardiography source localization. Pacing Clin Electrophysiol 26: 426-430, 2003.
29. Fenici R, Brisinda D, and Meloni AM. Clinical application of magnetocardiography. Expert Rev Mol Diagn 5: 291-313, 2005.
30. Fenici R, Nenonen J, Pesola K, Korhonen P, Lotjonen J, Makijarvi M, Toivonen L, Poutanen VP, Keto P, and Katila T. Nonfluoroscopic localization of an amagnetic stimulation catheter by multichannel magnetocardiography. Pacing Clin Electrophysiol 22: 1210-1220, 1999.
31. Fenici R, Brisinda D, Meloni AM, Sternickel K, and Fenici P. Clinical validation of machine learning for automatic analysis of multichannel magnetocardiography. Lecture Note Comp Sci 3504: 143-152, 2005.
32. Fenici R and Fenici P. Multiple monophasic action potential recording with a single magnetocardiographically localizable amagnetic catheter. In: Monophasic Action Potentials: Bridging Cell and Bedside, edited by Franz MR. New York: Futura, 1999.
33. Fleg JL. Ventricular arrhythmias in the elderly: prevalence, mechanisms, and therapeutic implications. Geriatrics 43: 23-29, 1988.
34. Folkow B and Svanborg A. Physiology of cardiovascular aging. Physiol Rev 73: 725-764, 1993.
35. Goldberg RJ, Bengtson J, Chen Z, Anderson KM, Locati E, and Levy D. Duration of the QT interval and total and cardiovascular mortality in healthy persons (the Framingham Heart Study experience). Am J Cardiol 67: 55-58, 1991.
36. Hailer B, Chaikovsky I, Auth-Eisernitz S, Schafer H, and Van Leeuwen P. The value of magnetocardiography in patients with and without relevant stenoses of the coronary arteries using an unshielded system. Pacing Clin Electrophysiol 28: 8-16, 2005.
37. Hänninen H, Takala P, Mäkijärvi M, Montonen J, Korhonen P, Oikarinen L, Nenonen J, Katila T, and Toivonen L. Detection of exercise-induced myocardial ischemia by multichannel magnetocardiography in patients with single vessel coronary artery disease. Ann Noninvasive Electrocardiol 5: 147-157, 2000.
38. Havranek S, Micek M, Paclt I, Slavicek J, Kittnar O, Dohnalova A, Brizman E, Hala P, Kittzlerova E, and Pisvejcova K. QT dispersion estimated from 80 body surface potential map leads and from standard 12-lead ECG in psychiatric patients treated with dosulepin. Prague Med Rep 105: 53-63, 2004.
39. International Conference on Harmonisation. ICH Draft Consensus Guideline: The Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals. [Online]. http:/www.ich.org/MediaServer.jser?@_ID=505&@_MODE=GLB[2002].
40. Kandori A, Shimizu W, Yokokawa M, Kamakura S, Miyatake K, Murakami M, Miyashita T, Ogata K, and Tsukada K. Reconstruction of action potential of repolarization in patients with congenital long-QT syndrome. Phys Med Biol 49: 2103-2105, 2004.
41. Kanzaki H, Nakatani S, Kandori A, Tsukada K, and Miyatake K. A new screening method to diagnose coronary artery disease using multichannel magnetocardiogram and simple exercise. Basic Res Cardiol 98: 124-132, 2003.
42. Koch H. Recent advances in magnetocardiography. J Electrocardiol 37 Suppl: 117-122, 2004.
43. Korhonen P, Montonen J, Mäkijärvi M, Katila T, Nieminen MS, and Toivonen L. Late fields of the magnetocardiographic QRS complex as indicators of propensity to sustained ventricular tachycardia after myocardial infarction. J Cardiovasc Electrophysiol 11: 413-420, 2000.
44. Korhonen P, Vaananen H, Makijarvi M, Katila T, and Toivonen L. Repolarization abnormalities detected by magnetocardiography in patients with dilated cardiomyopathy and ventricular arrhythmias. J Cardiovasc Electrophysiol 12: 772-777, 2001.
45. Lakatta EG. Cardiovascular regulatory mechanism in advanced age. Physiol Rev 73: 413-467, 1993.
46. Lee HN, Park TS, Lee SY, and Huh Y. Spatial filters based on independent component analysis for magnetic noise reduction in the magnetocardiogram. Med Biol Eng Comput 42: 532-534, 2004.
47. Liu B, Iden JB, Kovithavongs K, Gulamhusein R, Duff HJ, and Kavanagh KM. In vivo temporal and spatial distribution of depolarization and repolarization and the illusive murine T wave. J Physiol 555: 267-279, 2003.
48. Locati E and Schwartz PJ. Prognosis value of QT interval prolongation in postmyocardial infarction patients. Eur Heart J 8, Suppl A: 121-126, 1987.
49. Musso E, Stilli D, Olivetti G, Ricci R, and Lagrasta C. Body surface maps in chronically instrumented rats. In: Electrocardiology, edited by Abel H. Amsterdam: Elsevier Science, 1989.
50. Nakai K, Izumoto H, Kawazoe K, Tsuboi J, Oshima Y, Takanori O, Yoshioka K, Syozushima M, Manabu I, Shimizu T, and Yoshizawa M. Three-dimensional recovery time dispersion map by 64-channel magnetocardiography may demonstrate the location of a myocardial injury and heterogeneity of repolarization. Int J Cardiovasc Imaging. In press.
51. Nakaya Y. Magnetocardiography. Clin Phys Physiol Meas 13: 191-229, 1992.
52. Nenonen J. Magnetocardiography. In: SQUID Handbook, edited by Clarke J and Braginski A. Berlin: Wiley, 2005.
53. Nenonen J, Pesola K, Hanninen H, Lauerma K, Takala P, Makela T, Makijarvi M, Knuuti J, Toivonen L, and Katila T. Current-density estimation of exercise-induced ischemia in patients with multivessel coronary artery disease. J Electrocardiol 34: 37-42, 2001.
54. Park JW, Hill PM, Chung N, Hugenholtz PG, and Jung F. Magnetocardiography predicts coronary artery disease in patients with acute chest pain. Ann Noninvasive Electrocardiol 10: 312-323, 2005.
55. Perkiomaki JS, Sourander LB, Levomaki L, Raiha IJ, Puukka P, and Huikuri HV. QT dispersion and mortality in elderly. Ann Noninvasive Electrocardiol 6: 183-192, 2001.
56. Provan G, Stanton A, Sutton A, Rankin-Burkart A, and Laycock SK. Development of a surgical approach for telemetering guinea pigs as a model for screening QT interval effects. J Pharmacol Toxicol Methods 52: 223-228, 2005.
57. Ramanathan C and Rudy Y. Electrocardiographic imaging. I. Effect of torso inhomogeneities on body surface electrocardiographic potentials. J Cardiovasc Electrophysiol 12: 229-240, 2001.
58. Reardon M and Malik M. QT interval changes with age in an overtly healthy older population. Clin Cardiol 19: 949-952, 1996.
59. Saito J, Niwano S, Niwano H, Inomata T, Yumoto Y, Ikeda K, Inuo K, Kojima J, Horie M, and Izumi T. Electrical remodeling of the ventricular myocardium in myocarditis: studies of rat experimental autoimmune myocarditis. Circ J 66: 97-103, 2002.
60. Shah RR. Pharmacogenetic aspects of drug-induced torsade de pointes: potential tool for improving clinical drug development and prescribing. Drug Saf 27: 145-172, 2004.
61. Shulga SN, Korsun N, Bakarev A, and Maluskin AV. Effective magnetic dipole localization for magnetocardiography. In: Proceedings of the 14th International Conference on Biomagnetism, edited by Halgre E, Ahlfors S, Häimäläinen M, and Cohen D. Boston, MA: Biomag, 2004.
62. Siltanen P. Magnetocardiography. In: Comprehensive Electrocardiology, edited by Macfarlane PW and Lawrie TDW. London: Pergamon, 1989.
63. Statters DJ, Malik M, Ward DE, and Camm AJ. QT dispersion: problems of methodology and clinical significance. J Cardiovasc Electrophysiol 5: 672-685, 1999.
64. Steinberg BA, Rougin A, Watkins SP III, Hill P, Fernando D, and Resar JR. Magnetocardiogram recordings in a nonshielded environment - reproducibility and ischemia detection. Ann Noninvasive Electrocardiol 10: 152-160, 2005.
65. Steinhoff U, Knappe-Grueneberg S, Schnabel A, Trahams L, Smith F, Langley P, Murray A, and Koch H. Magnetocardiography for pharmacology safety studies requiring high patient throughput and reliability. J Electrocardiol 37, Suppl: 187-192, 2004.
66. Stilli D, Aimi B, Sgoifo A, Ciarlini P, Regoliosi G, Lagrasta C, Olivetti G, and Musso E. Dependence of temporal variability of ventricular recovery on myocardial fibrosis. Role of mechanoelectric feedback? Cardiovasc Res 37: 58-65, 1998.
67. Stilli D, Musso E, Sgoifo A, Parmigiani S, Olivetti G, Lagrasta C, Ricci R, Barone P, Ciarilini P, and Regoliosi G. Cardiac arrhythmias and beat-to-beat variability of QRST integral maps, in rats with left ventricular hypertrophy. In: Advances in Electrocardiology, edited by Antalóczy Z. Amsterdam: Elsevier Science, 1990.
68. Stilli D, Sgoifo A, Macchi M, Zaniboni M, De Iasio S, Cerbai E, Mugelli A, Lagrasta C, Olivetti G, and Musso E. Myocardial remodelling and arrhythmogenesis in moderate cardiac hypertrophy in rats. Am J Physiol Heart Circ Physiol 280: H142-H150, 2001.
69. Stroink G, Lamothe R, and Gardner MJ. Magnetocardiographic and electrocardiographic mapping studies. In: SQUID Sensors: Fundamentals, Fabrication and Applications, edited by Weinstock H. Amsterdam: Kluwer, 1996. (NATO ASI Ser.)
70. Taccardi B. Distribution of heart potentials on dog's thoracic surface. Circ Res 11: 862, 1962.
71. Takala P, Hänninen H, Montonen et al. J. Montonen J, Korhonen P, Makijarvi M, Nenonen J, Oikarinen L, Toivonen L, and Katila T. Heart rate adjustment of magnetic field map rotation in detection of myocardial ischemia in exercise magnetocardiography. Basic Res Cardiol 97: 88-96, 2002.
72. Uchida S, Iramina K, Goto K, and Ueno S. Current source imaging for high spatial resolution magnetocardiography in normal and abnormal rat cardiac muscles. J Appl Phys 87: 6205-6207, 2000.
73. Valverde ER, Biagetti MO, Bertran VR, Arini PD, Bidoggia H, and Quinteiro RA. Developmental changes of cardiac repolarization in rabbits: implications for the role of sex hormones. Cardiovasc Res 57: 625-631, 2003.
74. Van Leeuwen P, Hailer B, and Wehr M. Spatial distribution of QT intervals: an alternative approach to QT dispersion. Pacing Clin Electrophysiol 19: 1894-1899, 1996.
75. Wikswo JP and Barach J. Possible sources of new information in the magnetocardiogram. J Theor Biol 95: 721-729, 1982.
76. Williamson SJ and Kaufman L. Biomagnetism. J Magn Mat 22: 129-201, 1981.
77. Yamada S and Yamaguchi I. Magnetocardiograms in clinical medicine: unique information on cardiac ischemia, arrhythmias, and fetal diagnosis. Intern Med 44: 1-19, 2005.