Development of a surgical approach for telemetering guinea pigs as a model for screening QT interval effects

Journal of Pharmacological and Toxicological Methods

Volumn 52, Issue 2, 2005, Pages 223-228

  Provan, Gayle ^a   Stanton, Andrea ^a   Sutton, Anthea ^a   Rankin Burkart, Ann ^a   Laycock, Sarra K ^a  

^a IQVIA   (United States)

Author keywords

Blood pressure; ECG; Guinea pigs; Implantation; Methods; Surgery; Telemetry

Indexed keywords

ISOFLURANE; LEAD;

ABDOMINAL AORTA; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA RUPTURE; ARTERIAL PRESSURE; ARTICLE; BLOOD PRESSURE; CANNULATION; CAROTID ARTERY; CONTROLLED STUDY; ELECTROCARDIOGRAM; GUINEA PIG; IMPLANT; IMPLANTATION; INFORMATION PROCESSING; MALE; NONHUMAN; POSTOPERATIVE PERIOD; QT INTERVAL; SCREENING; SKIN DEFECT; SKIN INCISION; SURGICAL TECHNIQUE; SURVIVAL; SURVIVAL RATE; TELEMETRY; TRANSDUCER;

ANIMALS; BLOOD PRESSURE DETERMINATION; ELECTROCARDIOGRAPHY; ELECTRODES, IMPLANTED; GUINEA PIGS; LONG QT SYNDROME; MALE; MASS SCREENING; MODELS, ANIMAL; SURGICAL PROCEDURES, OPERATIVE; TELEMETRY; TORSADES DE POINTES;

ANIMALIA; CAVIA; CAVIA PORCELLUS;

EID: 23944454328     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2005.03.006     Document Type: Article

References (17)

1. L. Belardinelli, C. Antzelivitch, and M.A. Vos Assessing predictors of drug-induced Torsade de Pointes TIPS 24 2003 619 625
2. B.P. Brockway, P. Mills, and K. Kramer Fully implanted radio-telemetry for monitoring laboratory animals Laboratory Animals 27 1998 40 45
3. A.M. Brown, and D. Rampe Drug-induced long QT syndrome: Is HERG the root of all evil Pharmaceutical News 7 4 2000 15 20
4. A.J. Camm, M.J. Janse, D.M. Rosen, J. Cinca, and S.M. Cobbe Congenital and acquired long QT syndrome European Heart Journal 21 2000 1232 1237
5. L. Carlsson, O. Almgren, and G. Duker QTU-prolongation and Torsade de Pointes induced by putative class III atiarrhythmic agents in the rabbit. Etiology and interventions Journal of Cardiovascular Pharmacology 16 1990 276 285
6. F. De Clerck, A. Van de Water, J. D'Aubioul, H.R. Lu, K. Van Rossem, and A. Hermans In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: Application to the preclinical cardiovascular safety pharmacology of a new entity Fundamental and Clinical Pharmacology 16 2002 125 140
7. M.J. DePasquale, L.W. Ringer, R.L. Winslow, R.A. Bucholz, and A.A. Fossa Chronic monitoring of cardiovascular function in the conscious guinea pig using radio-telemetry Clinical and Experimental Hypertension 16 2 1994 245 260
8. B. Drolet, M. Khalifa, P. Daleau, B.A. Hamelin, and J. Turgeon Block of the rapid component of the delayed rectifier potassium current by the prokinetic agent cisapride underlies drug related lengthening of the QT interval Circulation 97 1998 204 210
9. W. Haverkamp, G. Briethardt, A.J. Camm, M.J. Janse, M.R. Rosen, and C. Antzelevitch The potential for QT prolongation and proarrhythmia by non-arrhythmic drugs: Clinical and regulatory implications European Heart Journal 21 2000 1216 1231
10. L.M. Hondeghem, K. Dujardin, and F. De Clerck Phase 2 prolongation, in the absence of instability and triangulation, antagonises class III proarrhythmia Cardiovascular Research 50 2001 345 353
11. ICH S7A (Step 5). International Conference on Harmonisation (ICH) guidelines. S7A: Safety Pharmacology Studies for Human Pharmaceuticals. www.ich.org
12. ICH S7B (Step 3). International Conference on Harmonisation (ICH) guidelines. S7B Revised: The Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) By Human Pharmaceuticals. www.ich.org
13. R. Netzer, A. Ebneth, U. Bischoff, and O. Pongs Screening lead compounds for QT interval prolongation Drug Discovery Today 6 2000 78 84
14. R. Shah Drug-induced prolongation of the QT interval: Regulatory dilemmas and implications for approval and labeling of a new chemical entity Fundamental & Clinical Pharmacology 16 2002 147 156
15. R. Shah The significance of QT interval in drug development British Journal of Clinical Pharmacology 54 2002 188 202
16. S.H.L. Thomas Drugs, QT interval abnormalities and ventricular arrhythmias Adverse Drug Reactions and Toxicology Reviews 13 1994 77 102
17. A. Williams, W.S. Redfern, A. Day, K.J. Gracie, and L. Patmore Prolongation of QTc interval by ketoconazole in conscious guinea-pigs implanted with ECG telemetry transducers British Journal of Pharmacology 119 1996 356P (Suppl.)