NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells

Cancer Research

Volumn 66, Issue 12, 2006, Pages 6008-6013

  Chang, Pei Yun ^a   Draheim, Kyle ^b   Kelliher, Michelle A ^b   Miyamoto, Shigeki ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETOPOSIDE; INTERCELLULAR ADHESION MOLECULE 1; ONCOPROTEIN; PROTEIN P50; PROTEIN TAL1; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CONTROLLED STUDY; GENE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; NF KAPPA B 1 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; T CELL LEUKEMIA;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; ETOPOSIDE; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA, T-CELL, ACUTE; MICE; MICE, TRANSGENIC; NF-KAPPA B P50 SUBUNIT; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC;

EID: 33745700226     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-0194     Document Type: Article

References (15)

1. Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell 1996;86:47-57.
2. Tremblay M, Herblot S, Lecuyer E, Hoang T. Regulation of pT alpha gene expression by a dosage of E2A, HEB, SCL. J Biol Chem 2003;278:12680-7.
3. O'Neil J, Shank J, Cusson N, Murre C, Kelliher M. TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. Cancer Cell 2004;5:587-96.
4. Talora C, Cialfi S, Oliviero C, et al. Cross-talk among Notch3, pre-TCR and Tal-1 in T-cell development and leukemogenesis. Blood 2006;107:3313-20.
5. Ferrando AA, Neuberg DS, Staunton J, et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 2002;1:75-87.
6. Chang PY, Miyamoto S. Nuclear factor-kappaB dimer exchange promotes a p21(waf1/cip1) superinduction response in human T leukemic cells. Mol Cancer Res 2006;4:101-12.
7. Wissink S, van de Stolpe A, Caldenhoven E, Koenderman L, van der Saag PT. NF-kappa B/Rel family members regulating the ICAM-1 promoter in monocytic THP-1 cells. Immunobiology 1997;198:50-64.
8. Krosl G, He G, Lefrancois M, et al. Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells. J Exp Med 1998;188:439-50.
9. Kelliher MA, Seldin DC, Leder P. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha. EMBO J 1996;15:5160-6.
10. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000;403:503-11.
11. Li Z, Wang X, Yu RY, et al. BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit. J Immunol 2005;174:205-14.
12. Otsuki T, Yano T, Clark HM, et al. Analysis of LAZ3 (BCL-6) status in B-cell non-Hodgkin's lymphomas:results of rearrangement and gene expression studies and a mutational analysis of coding region sequences. Blood 1995;85:2877-84.
13. Bernard M, Delabesse E, Smit L, et al. Helix-loop-helix (E2-5, HEB, TAL1 and Id1) protein interaction with the TCRalphadelta enhancers. Int Immunol 1998;10:1539-49.
14. Schlaeger TM, Schuh A, Flitter S, et al. Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Mol Cell Biol 2004;24:7491-502.
15. Aggarwal BB. Nuclear factor-kappaB:the enemy within. Cancer Cell 2004;6:203-8.