Bcr interacts with components of the endosomal sorting complex required for transport-I and is required for epidermal growth factor receptor turnover

Cancer Research

Volumn 66, Issue 12, 2006, Pages 6250-6257

  Olabisi, Oyenike O ^a   Mahon, Gwendolyn M ^a   Kostenko, Elena V ^a   Liu, Zhuoming ^a   Ozer, Harvey L ^a   Whitehead, Ian P ^a,b  

^a University of Medicine and Dentistry of New Jersey   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; CARRIER PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN; UNCLASSIFIED DRUG; VACUOLAR SORTING PROTEIN 28;

ANIMAL CELL; ARTICLE; CANCER GROWTH; CELL CULTURE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN TARGETING; UBIQUITINATION;

3T3 CELLS; ADENOSINE TRIPHOSPHATASES; ANIMALS; DNA-BINDING PROTEINS; ENDOSOMES; GTPASE-ACTIVATING PROTEINS; HELA CELLS; HL-60 CELLS; HUMANS; K562 CELLS; MICE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCR; RECEPTOR, EPIDERMAL GROWTH FACTOR; REPRESSOR PROTEINS; SUBCELLULAR FRACTIONS; TRANSCRIPTION FACTORS; UBIQUITIN; VESICULAR TRANSPORT PROTEINS;

EID: 33745700186     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-0536     Document Type: Article

References (49)

1. Maru Y. Molecular biology of chronic myeloid leukemia. Int J Hematol 2001;73:308-22.
2. Nowell PC, Hungerford DA. The etiology of leukemia: some comments on current studies. Semin Hematol 1966;3:114-21.
3. O'Dwyer ME, Druker BJ. Chronic myelogenous leukaemia-new therapeutic principles. J Intern Med 2001;250:3-9.
4. Lugo TG, Pendergast AM. Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 1990;247:1079-82.
5. Pendergast AM, Quilliam LA, Cripe LD, et al. BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell 1993;75:175-85.
6. McWhirter JR, Galasso DL, Wang JY. A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins. Mol Cell Biol 1993;13:7587-95.
7. Maru Y, Afar DE, Witte ON, Shibuya M. The dimerization property of glutathione S-transferase partially reactivates Bcr-Abl lacking the oligomerization domain. J Biol Chem 1996;271:15353-7.
8. Muller AJ, Young JC, Pendergast AM, et al. BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. Mol Cell Biol 1991;11:1785-92.
9. Whitehead IP, Campbell S, Rossman KL, Der CJ. Dbl family proteins. Biochim Biophys Acta 1997;1332:F1-23.
10. Nalefski EA, Falke JJ. The C2 domain calcium-binding motif: structural and functional diversity. Protein Sci 1996;5:2375-90.
11. Chuang TH, Xu X, Kaartinen V, Heisterkamp N, Groffen J, Bokoch GM. Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc Natl Acad Sci U S A 1995;92:10282-6.
12. Wetzler M, Talpaz M, Van Etten RA, Hirsh-Ginsberg C, Beran M, Kurzrock R. Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation. J Clin Invest 1993;92:1925-39.
13. Laurent E, Talpaz M, Wetzler M, Kurzrock R. Cytoplasmic and nuclear localization of the 130 and 160 kDa Bcr proteins. Leukemia 2000;14:1892-7.
14. Mahon GM, Wang Y, Korus M, et al. The c-Myc oncoprotein interacts with Bcr. Curr Biol 2003;13:437-41.
15. Voncken JW, Baram TZ, Gonzales-Gomez II, et al. Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product. Int J Mol Med 1998;2:577-83.
16. Kaartinen V, Nagy A, Gonzalez-Gomez I, Groffen J, Heisterkamp N. Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs. Dev Dyn 2002;223:517-25.
17. Kaartinen V, Gonzalez-Gomez I, Voncken JW, et al. Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development 2001;128:4217-27.
18. Voncken JW, van Schaick H, Kaartinen V, et al. Increased neutrophil respiratory burst in bcr-null mutants. Cell 1995;80:719-28.
19. Li L, Cohen SN. Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. Cell 1996;85:319-29.
20. Feng GH, Lih CJ, Cohen SN. TSG101 protein steady-state level is regulated posttranslationally by an evolutionarily conserved COOH-terminal sequence. Cancer Res 2000;60:1736-41.
21. Xie W, Li L, Cohen SN. Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency. Proc Natl Acad Sci U S A 1998;95:1595-600.
22. Ruland J, Sirard C, Elia A, et al. p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101. Proc Natl Acad Sci U S A 2001;98:1859-64.
23. Wagner KU, Krempler A, Qi Y, et al. Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues. Mol Cell Biol 2003;33:150-62.
24. Watanabe M, Yanagi Y, Masuhiro Y, et al. A putative tumor suppressor, TSG101, acts as a transcriptional suppressor through its coiled-coil domain. Biochem Biophys Res Commun 1998;245:900-5.
25. Li L, Liao J, Ruland J, Mak TW, Cohen SN. A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control. Proc Natl Acad Sci USA 2001;98:1619-24.
26. Zhong Q, Chen Y, Jones D, Lee WH. Perturbation of TSG101 protein affects cell cycle progression. Cancer Res 1998;58:2699-702.
27. Babst M, Odorizzi G, Estepa EJ, Emr SD. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic 2000;1:248-58.
28. Katzmann DJ, Babst M, Emr SD. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 2001;106:145-55.
29. Whitehead I, Kirk H, Tognon C, Trigo-Gonzalez G, Kay R. Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C. J Biol Chem 1995;270:18388-95.
30. Bishop N, Woodman P. ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. Mol Biol Cell 2000;11:227-39.
31. Chowdary DR, Dermody JJ, Jha KK, Ozer HL. Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway. Mol Cell Biol 1994;14:1997-2003.
32. Whitehead IP, Lambert QT, Glaven JA, et al. Dependence of Dbl and Dbs transformation on MEK and NF-κB activation. Mol Cell Biol 1999;19:7759-70.
33. Rossman KL, Cheng L, Mahon GM, et al. Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. J Biol Chem 2003;278:18393-400.
34. Babst M. A protein's final ESCRT. Traffic 2005;6:2-9.
35. Bishop N, Horman A, Woodman P. Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. J Cell Biol 2002;157:91-101.
36. Bishop N, Woodman P. TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes. J Biol Chem 2001;276:11735-42.
37. Babst M, Sato TK, Banta LM, Emr SD. Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p. EMBO J 1997;16:1820-31.
38. Babst M, Wendland B, Estepa EJ, Emr SD. The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J 1998;17:2982-93.
39. Babst M, Katzmann DJ, Snyder WB, Wendland B, Emr SD. Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body. Dev Cell 2002;3:283-9.
40. Odorizzi G, Katzmann DJ, Babst M, Audhya A, Emr SD. Brol is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae. J Cell Sci 2003;116:1893-903.
41. Yoshimori T, Yamagata F, Yamamoto A, et al. The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells. Mol Biol Cell 2000;11:747-63.
42. Bache KG, Slagsvold T, Cabezas A, Rosendal KR, Raiborg C, Stenmark H. The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Mol Biol Cell 2004;15:4337-46.
43. Lu Q Hope LW, Brasch M, Reinhard C, Cohen SN. TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. Proc Natl Acad Sci U S A 2003;100:7626-31.
44. Reuther GW, Fu H, Cripe LD, Collier RJ, Pendergast AM. Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family. Science 1994;266:129-33.
45. Malmberg EK, Andersson CX, Gentzsch M, et al. Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3. J Cell Sci 2004;117:5535-41.
46. Radziwill G, Erdmann RA, Margelisch U, Moelling K. The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain. Mol Cell Biol 2003;23:4663-72.
47. Katzmann DJ, Odorizzi G, Emr SD. Receptor down-regulation and multivesicular-body sorting. Nat Rev Mol Cell Biol 2002;3:893-905.
48. Babst M, Katzmann DJ, Estepa-Sabal EJ, Meerloo T, Emr SD. Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell 2002;3:271-82.
49. Doyotte A, Russell MR, Hopkins CR, Woodman PG. Depletion of TSG101 forms a mammalian "Class E" compartment: a multicisternal early endosome with multiple sorting defects. J Cell Sci 2005;118:3003-17.