Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy

Acta Crystallographica Section F: Structural Biology and Crystallization Communications

Volumn 62, Issue 7, 2006, Pages 613-617

  Kursula, Petri ^a,b   Flodin, Susanne ^a   Ehn, Maria ^a   Hammarström, Martin ^a   Schüler, Herwig ^a,c   Nordlund, Pär ^a   Stenmark, Pål ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF OULU   (Finland)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYTIDINE TRIPHOSPHATE SYNTHASE; LIGASE; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; ESCHERICHIA COLI; FEEDBACK SYSTEM; GENETICS; HUMAN; ISOLATION AND PURIFICATION; MOLECULAR CLONING; MOLECULAR GENETICS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; BINDING SITES; CARBON-NITROGEN LIGASES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; FEEDBACK; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 33745699187     PISSN: 17443091     EISSN: 17443091     Source Type: Journal    
DOI: 10.1107/S1744309106018136     Document Type: Article

References (37)

1. Brünger, A. T. (1992). Nature (London), 355, 472-474.
2. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T. & Warren, G. L. (1998). Acta Cryst. D54, 905-921.
3. Dereuddre-Bosquet, N., Roy, B., Routledge, K., Clayette, P., Foucault, G. & Lepoivre, M. (2004). Antiviral Res. 61, 67-70.
4. Diederichs, K. & Karplus, P. A. (1997). Nature Struct. Biol. 4, 269-275.
5. Emsley, P. & Cowtan, K. (2004). Acta Cryst. D60, 2126-2132.
6. Endrizzi, J. A., Kim, H., Anderson, P. M. & Baldwin, E. P. (2004). Biochemistry, 43, 6447-6463.
7. Endrizzi, J. A., Kim, H., Anderson, P. M. & Baldwin, E. P. (2005). Biochemistry, 44, 13491-13499.
8. Engh, R. A. & Huber, R. (1991). Acta Cryst. A47, 392-400.
9. Evans, P. (2006). Acta Cryst. D62, 72-82.
10. Fenn, T. D., Ringe, D. & Petsko, G. A. (2003). J. Appl. Cryst. 36, 944-947.
11. Goto, M., Omi, R., Nakagawa, N., Miyahara, I. & Hirotsu, K. (2004). Structure, 12, 1413-1423.
12. Gouet, P., Courcelle, E., Stuart, D. I. & Metoz, F. (1999). Bioinformatics, 15, 305-308.
13. Han, G. S., Sreenivas, A., Choi, M. G., Chang, Y. F., Martin, S. S., Baldwin, E. P. & Carman, G. M. (2005). J. Biol. Chem. 280, 38328-38336.
14. Hindenburg, A. A., Taub, R. N., Grant, S., Chang, G. & Baker, M. A. (1985). Cancer Res. 45, 3048-3052.
15. Hofer, A., Steverding, D., Chabes, A., Brun, R. & Thelander, L. (2001). Proc. Natl Acad. Sci. USA, 98, 6412-6416.
16. Kang, G. J., Cooney, D. A., Moyer, J. D., Kelley, J. A., Kim, H. Y., Marquez, V. E. & Johns, D. G. (1989). J. Biol. Chem. 264, 713-718.
17. Krissinel, E. & Henrick, K. (2004). Acta Cryst. D60, 2256-2268.
18. Kuilenburg, A. B. van, Meinsma, R., Vreken, P., Waterham, H. R. & van Gennip, A. H. (2000). Biochim. Biophys. Acta, 1492, 548-552.
19. Leslie, A. G. W. (1992). Jnt CCP4/ESF-EACBM Newsl. Protein Crystallogr. 26.
20. Long, C. W. & Pardee, A. B. (1967). J. Biol. Chem. 242, 4715-4721.
21. Lunn, F. A. & Bearne, S. L. (2004). Eur. J. Biochem. 271, 4204-4212.
22. Murshudov, G. N., Vagin, A. A. & Dodson, E. J. (1997). Acta Cryst. D53, 240-255.
23. Ostrander, D. B., O'Brien, D. J., Gorman, J. A. & Carman, G. M. (1998). J. Biol. Chem. 273, 18992-19001.
24. Pappas, A., Yang, W. L., Park, T. S. & Carman, G. M. (1998). J. Biol. Chem. 273, 15954-15960.
25. Pettersen, E. F., Goddard, T. D., Huang, C. C., Couch, G. S., Greenblatt, D. M., Meng, E. C. & Ferrin, T. E. (2004). J. Comput. Chem. 25, 1605-1612.
26. Philippsen, A. (2003). DINO: Visualizing Structural Biology. http:// www.dino3d.org.
27. Politi, P. M., Xie, F., Dahut, W., Ford, H. J., Kelley, J. A., Bastian, A., Setser, A., Allegra, C. J., Chen, A. P., Hamilton, J. M., Arbuck, S. F., Linz, P., Brammer, H. & Grem, J. L. (1995). Cancer Chemother. Pharmacol. 36, 513-523.
28. Sanner, M. F., Olson, A. J. & Spehner, J. C. (1996). Biopolymers, 38, 305-320.
29. Thomas, P. E., Lamb, B. J. & Chu, E. H. (1988). Biochim. Biophys. Acta, 953, 334-344.
30. Vagin, A. & Teplyakov, A. (1997). J. Appl. Cryst. 30, 1022-1025.
31. Verschuur, A. C., Van Gennip, A. H., Leen, R., Meinsma, R., Voute, P. A. & van Kuilenburg, A. B. (2000a). Br. J. Haematol. 110, 161-169.
32. Verschuur, A. C., Van Gennip, A. H., Leen, R., Muller, E. J., Elzinga, L., Voute, P. A. & Van Kuilenburg, A. B. (2000b). Eur. J. Cancer, 36, 627-635.
33. Whelan, J., Phear, G., Yamauchi, M. & Meuth, M. (1993). Nature Genet. 3, 317-322.
34. Willemoes, M. (2004). Arch. Biochem. Biophys. 424, 105-111.
35. Willemoes, M. & Sigurskjold, B. W. (2002). Eur. J. Biochem. 269, 4772-4779.
36. Williams, J. C., Kizaki, H., Weber, G. & Morris, H. P. (1978). Nature (London), 271, 71-73.
37. Zhang, H., Cooney, D. A., Zhang, M. H., Ahluwalia, G., Ford, H. J. & Johns, D. G. (1993). Cancer Res. 53, 5714-5720.