Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins

Proteomics

Volumn 6, Issue 12, 2006, Pages 3718-3727

  Batista, Cesar V F ^a   D'Suze, Gina ^a,b,e   Gómez Lagunas, Froylan ^c   Zamudio, Fernando Z ^a   Encarnación, Sergio ^d   Sevcik, Carlos ^a,b   Possani, Lourival D ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^b INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^c Medical School   (Mexico)

^d INSTITUTO DE CIENCIAS FÍSICAS   (Mexico)

^e IVIC CBB   (Venezuela)

Author keywords

MALDI TOF MS; Mass spectrometry; N terminal sequencing; Peptide mass fingerprinting; Peptide sequencing

Indexed keywords

AMINO ACID; PEPTIDE; POTASSIUM CHANNEL; PROTEIN TDK2; PROTEIN TDK3; SCORPION VENOM; SODIUM CHANNEL; TITYUS TOXIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; DRUG MECHANISM; FINGER DERMATOGLYPHICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEOMICS; SCORPION;

AMINO ACID SEQUENCE; ANIMALS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHYSIOLOGY; HYDROLYSIS; MOLECULAR WEIGHT; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PROTEOME; SCORPION VENOMS; SCORPIONS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPODOPTERA; TOXINS, BIOLOGICAL; TRYPSIN;

SCORPIONES; TITYUS DISCREPANS;

EID: 33745697811     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.200500525     Document Type: Article

References (32)

1. Possani, L. D., Selisko, B., Gurrola, G., Perspect Drug Discov. Des. 1999, 15/16, 15-40.
2. Possani, L. D., Becerril, B., Delepierre, M., Tytgat, T., Eur. J. Biochem. 1999, 264, 287-300.
3. Tytgat, J., Chandy, K. G., Garcia, M. L., Gutman, G. A. et al., Trends Pharmacol. Sci. 1999, 20, 444-447.
4. Mota, J. V., Ghersy de Nieto, M. T., Bastardo, M. C., Rodriguez, J. C. et al., Bol. Hosp. Niños 1994, 30, 36-40.
5. Ghersy de Nieto, M. T., Ortega, O. M. A., Castellini, P., Mota, J. et al., Arch. Venez. Puer. Pediatr. 2002, 65, 150-158.
6. D'Suze, G., Comellas, A., Pesce, L., Sevcik, C., Sanchez-de-León, R., Toxicon 1999, 37, 173-180.
7. D'Suze, G., Moncada, S., González, C., Sevcik, C. et al., Toxicon 2003, 41, 367-375.
8. D'Suze, G., Salazar, V., Díaz, P., Sevcik, C. et al., Toxicon 2004, 44, 851-860.
9. Novoa, E., D'Suze, G., Winter, M., Crespo, A. et al., Resp. Physiol. Neurobiol. 2003, 134, 33-41.
10. Pimenta, A. M., De Marco Almeida, F., de Lima, M. E., Martin-Eauclaire, M. F., Bougis, P. E., Rapid Commun. Mass Specrom. 2003, 17, 413-418.
11. Batista, C. V. F., del Pozo, L., Zamudio, F. Z., Contreras, S. et al., J. Chromatogr. B 2004, 803, 55-66.
12. Diego-García, E., Batiste, C. V. F., García-Góez, B. I., Lucas, S. et al., Toxicon 2005, 45, 273-283.
13. Zamudio, F. Z., Conde, R., Arevalo, C., Becerril, B. et al., J. Biol. Chem. 1997, 272, 11886-11894.
14. Kleiber, K., Williams, N., Roberts, T. M., Papazian, D. M. et al., Neuron 1990, 5, 221-226.
15. Hamill, O. P., Marty, A., Neher, E., Sakmann, B., Sigworth, F. J., Pflügers Arch. 1981, 391, 85-100.
16. Becerril, B., Marangoni, S., Possani, L. D., Toxicon 1997, 35, 821-835.
17. D'Suze, G., Zamudio, F. Z., Gómez-Lagunas, F., Possani, L., FEBS Lett. 1999, 456, 146-148.
18. D'Suze, G., Batista, C. V. F., Frau, A., Murgia, A. R. et al., Arch. Biochem. Biophys. 2004, 430, 256-263.
19. D'Suze, G., Sevcik, C., Batista, C., Zamudio, F., Possani, L., Toxicon 2004, 43, 263-272.
20. Rodríguez de la Vega, R. C., Possani, L. D., Toxicon 2004, 43, 865-875.
21. Hatta, S., Sakamoto, J., Horio, Y., Med. Electron. Microsc. 2002, 35, 117-126.
22. Beeton, C., Pennington, M. W., Wulff, H., Singh, S. et al., Mol. Pharmacol. 2005, 67, 1369-1381.
23. Rodríguez de Vega, R. C., Possani, L. D., Toxicon 2005, 46, 831-844.
24. D'Suze, G., Corona, F., Possani, L. D., Sevcik, C., Toxicon 1996, 34, 591-598.
25. Possani, L. D., Merino, E., Corona, M., Bolivar, F., Becerril, B., Biochimie 2000, 82, 861-868.
26. D'Suze, G., Sevcik, C., Pérez, J. F., Fox, J., Toxicon 1997, 35, 1683-1689.
27. Bagdány, M., Batista, C. V. F., Valdez-Cruz, N. A., Somodi, S. et al., Mol. Pharmacol. 2005, 67, 1034-1044.
28. Batista, C. V. F., Gómez-Lagunas, F., Rodriguez de la Vega, R. C., Hajduc, P. et al., Biochim. Biophys. Acta 2002, 1601, 123-131.
29. Cociancich, S., Goyffon, M., Bontemps, F., Bulet, P. et al., Biochem. Biophys. Res. Commun. 1993, 194, 17-22.
30. Conde, R., Zamudio, F. Z., Rodríguez, M. H., Possani, L. D., FEBS Lett. 2000, 471, 165-168.
31. Rogowski, R. S., Krueger, B. K., Collins, J. H., Blaustein, M. P., Proc. Natl Acad. Sci. USA 1994, 91, 1475-1479.
32. Zhu, S., Tytgat, J., Cell. Mol. Life Sci. 2004, 67, 1751-1763.