Ardiscretin a novel arthropod-selective toxin from Tityus discrepans scorpion venom

Toxicon

Volumn 43, Issue 3, 2004, Pages 263-272

  D'Suze, G ^a   Sevcik, C ^a   Corona, M ^b   Zamudio, F Z ^b   Batista, C V F ^b   Coronas, F I ^b   Possani, L D ^b  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

Author keywords

cDNA; Na+ channel; Scorpion toxin; Sequence; Squid giant axon; Tityus discrepans

Indexed keywords

ARDISCRETIN; ARTHROPOD VENOM; CHLORPHENOTANE; COMPLEMENTARY DNA; CYSTEINE; DISULFIDE; SCORPION VENOM; SODIUM CHANNEL; SODIUM ION; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPOLARIZATION; GIANT AXON; INVERTEBRATE; MALE; MASS SPECTROMETRY; MOLECULAR CLONING; MOUSE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; SCORPION; SEQUENCE ANALYSIS; SODIUM CURRENT; TITYUS DISCREPANS;

AMINO ACID SEQUENCE; ANIMALS; ARTHROPODS; BASE SEQUENCE; DNA PRIMERS; MALE; MICE; MOLECULAR SEQUENCE DATA; NEUROTOXINS; PHYLOGENY; POLYMERASE CHAIN REACTION; SCORPION VENOMS; SEQUENCE ALIGNMENT; SODIUM CHANNELS;

ARTHROPODA; CEPHALOPODA; DECAPODA (CRUSTACEA); GRYLLIDAE; INSECTA; INVERTEBRATA; SCORPIONES; TITYUS; TITYUS DISCREPANS;

EID: 1642389248     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2003.12.004     Document Type: Article

References (39)

1. Becerril B., Corona M., García C., Bolivar F., Possani L.D. Cloning of genes encoding scorpion toxins: an interpretive review. J. Toxicol. Toxin Rev. 14:1995;339-357.
2. Ben Khalifa R., Stankiewics M., Lapied B., Turkov M., Zilberberg N., Gurevitz M., Pelhate M. Refined electrophysiological analysis suggests that a depressant toxin is a sodium channel opener rather than a blocker. Life Sci. 61:1997;819-830.
3. Brune D.C. Alkylation of cysteine with acrylamide for protein sequence analysis. Anal. Biochem. 207:1992;285-290.
4. Chirgwin J.M., Przybyla A.E., MacDonald R.J., Rutter W.J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:1979;5294-5299.
5. +-channels blocking peptides from scorpions of the genus Centruroides. FEBS Lett. 532:2002;121-126.
6. - channel ligand from the venom of the scorpion. Am. J. Physiol. Cell. Physiol. 264:1993;C361-C369.
7. De Lima M.E., Martin-Euclaire M.F. The toxins purified from Tityus serrulatus (Lutz & Melo) venom. J. Toxicol. Toxin Rev. 14:1995;457-481.
8. De Lima M.E., Martin-Euclaire M.F., Diniz C.R., Rochat H. Tityus serrulatus toxin VII bears pharmacological properties of both α-toxin and insect toxin from scorpion venoms. Biochem. Biophys. Res. Commun. 139:1986;296-302.
9. De Maagd R.A., Bravo A., Crickmore N. How Bacillus thuringiensis has evolved specific toxins to colonize the insect world. Trends Genet. 17:2001;193-199.
10. D'Suze G., Sevcik C., Ramos M. Presence of curarizing polypeptides and a muscarinic pancreatitis-inducing fraction without muscarinic effects in the venom of the Venezuelan scorpion Tityus discrepans (Karsch). Toxicon. 33:1995;333-345.
11. D'Suze G., Corona F., Possani L.D., Sevcik C. HPLC purification and amino acid sequence of toxins from the muscarinic fraction of Tityus discrepans scorpion venom. Toxicon. 34:1996;591-598.
12. D'Suze G., Zamudio F., Gomez-Lagunas F., Possani L.D. A novel K+ channel blocking toxin from Tityus discrepans scorpion venom. FEBS Lett. 456:1999;146-148.
13. D'Suze G., Moncada S., González C., Sevcik C., Aguilar V., Alagón A. Relationship between plasmatic levels of IL6, IL1-α, TNF-α, PTT, PT, amylasemia, Glycemia, and venom concentration following Tityus scorpion sting. Toxicon. 41:2003;367-375.
14. Escoubas P., Stankiewics M., Takaoka T., Pelhate M., Romi-Lebrun R., Wu F.Q., Nakajima T. Sequence and electrophysiological characterization of two insect-selective excitatory toxins from the venom of the Chinese scorpion Buthus martensi. FEBS Lett. 483:2000;175-180.
15. Gordon D., Gurevitz M. The selectivity of scorpion α-toxins for sodium channel subtypes is determined by subtle variations at the interacting surface. Toxicon. 41:2003;125-128.
16. Higgins D.G., Sharp P.M. Fast and sensitive multiple sequence alignments on a microcomputer. CABIOS. 5:1989;151-153.
17. Higgins D.G., Bleasby A.J., Fuchs R. CLUSTAL V: improved software for multiple sequence alignment. CABIOS. 8:1991;189-191.
18. Hodgkin A.L., Katz B. The effect of sodium ions on the electrical activity of the giant axon of the squid. J. Physiol. 108:1949;37-77.
19. Hollander M., Wolfe D.A. Nonparametric Statistical Procedures. 1973;Wiley, New York.
20. Jablonski M.J., Jackson P.L., Krishna N.R. Solution structure of an insect-specific neurotoxin from the new world scorpion Centruroides sculpturatus Ewing. Biochemistry. 40:2001;8273-8282.
21. Martin-Eauclaire M.F., Ceard B., Ribeiro A.M., Diniz C.R., Rochat H., Bougis P.E. Molecular cloning and nucleotide sequence analysis of a cDNA encoding the main β-neurotoxin from the venom of the South American scorpion Tityus serrulatus. FEBS Lett. 302:1992;220-222.
22. McCutchen B.F., Hammock B.D. Recombinant baculovirus expressing an insect-selective neurotoxin. Hedin P.A., Menn J.J., Hollingworth R.M. Natural and Engineered Pest Management Agent. 1994;348-367 American Chemical Society Symposium Series, Washington, DC.
23. Nakawaka Y., Lee Y.M., Lehmberg E., Herrmann R., Herrmann R., Moskowitz H., Jones A.D., Hammock B.D. Anti-insect toxin 5 (AaIT5) from A. australis. Eur. J. Biochem. 246:1997;496-501.
24. Narahashi T. Mode of action of DDT and allethrin on nerve: cellular and molecular mechanisms. Residue Rev. 25:1969;275-288.
25. Pelhate M., Zlotkin E. Actions of insect toxin and other toxins derived from the venom of the scorpion Androctonus australis on isolated giant axons of the cockroach (Periplaneta americana). J. Exp. Biol. 97:1982;67-77.
26. Perriere G., Gouy M. WWW-Query: an on-line retrieval system for biological sequence banks. Biochimie. 78:1996;364-369.
27. Pimenta A.M., Martin-Euclaire M.F., Rochat H., Figueiredo S.G., Kalapothakis E., Afonso L.C., De Lima M.E. Purification, amino-acid sequence and partial characterization of two toxins with anti-insect activity from the venom of the South America scorpion Tityus bahiensis (Buthidae). Toxicon. 39:2001;1009-1019.
28. +-channels. Eur. J. Biochem. 264:1999;287-300.
29. Possani L.D., Merino E., Corona M., Bolivar F., Becerril B. Peptides and genes coding for scorpion toxins that affect ion-channels. Biochimie. 82:2000;861-868.
30. Possani L.D., Merino E., Corona M., Becerril B. Scorpion genes and peptides specific for potassium channels: structure, function and evolution. Ménez A. Perspectives in Molecular Toxinology. 2002;201-214 Wiley, New York.
31. Rojas E., Armstrong C.M. Sodium conductance activation without inactivation in pronase-perfused axons. Nat. New Biol. 229:1971;177-178.
32. Selisko B., Garcia C., Becerril B., Delepierre M., Possani L.D. An insect-specific toxin from Centruroides noxius Hoffmann. CDNA, primary structure, three-dimensional model and electrostatic surface potentials in comparison with other toxin variants. Eur. J. Biochem. 242:1996;235-242.
33. Sevcik C., Narahashi T. Effect of proteolytic enzymes on ionic conductances of squid axon membranes. J. Memb. Biol. 24:1975;329-341.
34. Tytgat J., Chandy G.K., Garcia M.L., Gutman G.A., Martin-Eauclaire M.F., van del Walt J., Possani L.D. A unified nomenclature for short-chain peptides isolated from scorpion venoms: α-KTx molecular subfamilies. Trends Pharmacol. Sci. 20:1999;444-447.
35. Wang C.M., Narahashi T., Yamada M. The neurotoxic action of dieldrin and its derivatives in the cockroach. Pest. Biochem. Physiol. 1:1971;84-91.
36. Wu C.H., Van Den Bercken J., Narahashi T. The structure-activity relationship of DDT analogs in crayfish giant axons. Pest. Biochem. Physiol. 5:1975;142-149.
37. Zlotkin E. The insect voltage-gated sodium channel as target of insecticides. Annu. Rev. Entomol. 44:1999;429-455.
38. Zlotkin E., Eitan M., Bindokan V.P., Adams M.E., Moyer M., Burkhart W., Fowler E. Functional duality and structural uniqueness of depressant insect-selective neurotoxins. Biochemistry. 30:1991;4814-4821.
39. Zlotkin E., Moskowitz H., Herrmann R., Pelhate M., Gordon D. Insect sodium channel as the target for insect-selective neurotoxins from scorpion venom. Dark J.M. Molecular action of insecticides on ion channels. 1995;56-85. Washington, DC:ACS.