Highly Enantioselective Construction of a Chiral Tertiary Carbon Center by Alkynylation of a Cyclic N-Acyl Ketimine: An Efficient Preparation of HIV Therapeutics

Angewandte Chemie - International Edition

Volumn 43, Issue 2, 2003, Pages 216-218

  Jiang, Biao ^a   Si, Yu Gui ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Alkynes; Amino alcohols; Drug design; Ketimines; Zinc

Indexed keywords

AMINES; CATALYST SELECTIVITY; SYNTHESIS (CHEMICAL); VIRUSES;

ALKYNYLATION; ENANTIOSELECTIVITY;

ENZYME INHIBITION;

BENZENE DERIVATIVE; CARBON; CHLORAMPHENICOL DERIVATIVE; IMINE; KETONE DERIVATIVE; LIGAND; RNA DIRECTED DNA POLYMERASE INHIBITOR; TERTIARY AMINE;

ALKYNYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CHIRALITY; DIASTEREOISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ALKYNES; ANTI-HIV AGENTS; CARBON; STEREOISOMERISM;

EID: 0347753811     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200352301     Document Type: Article

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19. 20 = + 74.3 (c = 0.6, MeOH).