Bioinformatics analysis of two-component regulatory systems in Staphylococcus epidermidis

Chinese Science Bulletin

Volumn 49, Issue 12, 2004, Pages 1267-1271

  Qin, Zhiqiang ^a   Zhong, Yang ^b,c   Zhang, Jian ^d   He, Youyu ^e   Wu, Yang ^a   Jiang, Juan ^a   Chen, Jiemin ^a   Luo, Xiaomin ^d   Qu, Di ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c SHANGHAI CENTER FOR BIOINFORMATION TECHNOLOGY   (China)

^d SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^e Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

Bioinformatics; Drug target; Histidine kinase; Response regulator; Staphylococcus epidermidis; Two component regulatory system

Indexed keywords

BACILLUS SUBTILIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 33745690599     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1360/03wc0384     Document Type: Article

References (24)

1. Rupp, M. E., Archer, G. L., Coagulase-negative staphylococci: Pathogens associated with medical progress, Clin. Infect. Dis., 1994, 19: 231-243.
2. Thylefors, J. D., Harbarth, S., Pittet, D., Increasing bacteremia due to coagulase-negative staphylococci: fiction or reality? Infect Control Hosp Epidemiol., 1998, 19: 581-589.
3. Zhang, X. Q., Ren, S. X., Li, H. L. et al., Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228), Mol. Microbiol., 2003, 49: 1577-1593.
4. Stephenson, K., Hoch, J. A., Two-component and phosphorelay signal-transduction systems as therapeutic targets, Curr. Opin. Pharmacol., 2002, 2: 507-512.
5. Schwede, T., Kopp, J., Guex, N. et al., SWISS-MODEL: An automated protein homology-modelling server, Nucleic Acids Res., 2003, 31: 3381-3385.
6. Guex, N., Peitsch, M. C., SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modelling, Electrophoresis, 1997, 18: 2714-2723.
7. Peitsch, M. C., Protein modelling by E-mail, Bio/Technology, 1995, 13: 658-660.
8. Throup, J. P., Koretke, K. K., Bryant, A. P. et al., A genomic analysis of two-component signal transduction in Streptococcus pneumoniae, Mol. Microbiol., 2000, 35: 566-576.
9. Lange, R., Wagner, C., de Saizieu, A. et al., Domain organization and molecular characterization of 13 two-component systems identified by genome sequencing of Streptococcus pneumoniae, Gene, 1999, 237: 223-234.
10. Vuong, C., Gerke, C., Somerville, G. A. et al., Quorum-sensing control of biofilm factors in Staphylococcus epidermidis, J. Infect Dis., 2003, 188: 706-718.
11. Fabret, C., Hoch, J. A., A two-component signal transduction system essential for growth of Bacillus subtilis: Implications for anti-infective therapy, J. Bacteriol., 1998, 180: 6375-6383.
12. Giraudo, A. T., Calzolari, A., Cataldi, A. A. et al., The sae locus of Staphylococcus aureus encodes a two-component regulatory system, FEMS Microbiol. Lett., 1999, 177: 15-22.
13. Fournier, B., Hooper, D. C., A new two-component regulatory system involved in adhesion, autolysis, and extracellular proteolytic activity of Staphylococcus aureus, J. Bacteriol., 2000, 182: 3955-3954.
14. Yarwood, J. M., McCormick, J. K., Schlievert, P. M., Identification of a novel two-component regulatory system that acts in global regulation of virulence factors of Staphylococcus aureus, J. Bacteriol., 2001, 183: 1113-1123.
15. + antiporter, influences expression of the phoPR operon and production of alkaline phosphatases, J. Bacteriol., 2001, 183: 2505-2515.
16. Recsei, P., Kreiswirth, B., O' Reilly, M. et al., Regulation of exo protein gene expression in Staphylococcus aureus by agar, Mol. Gen. Genet., 1986, 202: 58-61.
17. Brunskill, E. W., Bayles, K. W., Identification of LytSR-regulated genes from Staphylococcus aureus, J. Bacteriol., 1996, 178: 5810 -5812.
18. Dartois, V., Debarbouille, M., Kunst, F. et al., Characterization of a novel member of the DegS-DegU regulon affected by salt stress in Bacillus subtilis, J. Bacteriol., 1998, 180: 1855-1861.
19. Tanaka, T., Saha, S. K., Tomomori, C. et al., NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ, Nature, 1998, 396: 88-92.
20. Cho, H. S., Lee, S. Y., Yan, D. et al., NMR structure of activated Che Y, J. Mol. Biol., 2000, 297: 543-551.
21. Stephenson, K., Hoch, J. A., Virulence and antibiotic resistance-associated two-component signal transduction systems of Gram-positive pathogenic bacteria as targets for antimicrobial therapy, Pharmacol. Ther., 2002, 93: 293-305.
22. Roychoudhury, S., Zielinski, N. A., Ninfa, A. J. et al., Inhibitors of two-component signal transduction systems: Inhibition of alginate gene activation in Pseudomonas aeruginosa, Proc. Natl. Acad. Sci. USA, 1993, 90: 965-969.
23. Stephenson, K., Yamaguchi, Y., Hoch, J. A., The mechanism of action of inhibitors of bacterial two-component signal transduction systems, J. Biol. Chem., 2000, 275: 38900-38904.
24. Hilliard, J. J., Goldschmidt, R. M., Licata, L. et al., Multiple mechanisms of action for inhibitors of histidine protein kinases from bacterial two-component systems, Antimicrob Agents Chemother, 1999, 43: 1693-1699.