Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains

Behavior Genetics

Volumn 36, Issue 4, 2006, Pages 536-552

  Crabbe, John C ^a,e   Metten, Pamela ^a   Ponomarev, Igor ^b   Prescott, Carol A ^c   Wahlsten, Douglas ^d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF WINDSOR   (Canada)

^e PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Acute tolerance; Chronic tolerance; Ethanol; Hypothermia; Inbred mouse strains; Loss of righting reflex; Pharmacogenetics

Indexed keywords

ALCOHOL;

ALCOHOL METABOLISM; ALCOHOL TOLERANCE; ANIMAL EXPERIMENT; ARTICLE; BODY TEMPERATURE; FEMALE; GENOTYPE; HYPOTHERMIA; INBRED STRAIN; MALE; MEASUREMENT; MOUSE; NONHUMAN; PHARMACOGENETICS; RIGHTING REFLEX; STRAIN DIFFERENCE;

ALCOHOLISM; ANIMALS; BRAIN; ETHANOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HYPNOTICS AND SEDATIVES; HYPOTHERMIA; MALE; MICE; MICE, INBRED A; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, INBRED STRAINS; MOTOR ACTIVITY; REFLEX; SPECIES SPECIFICITY;

ANIMALIA;

EID: 33745676769     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10519-006-9067-6     Document Type: Article

References (58)

1. Allan, A. M., and Harris, R. A. (1991). Neurochemical studies of genetic differences in alcohol action. In J. C. Crabbe and R. A. Harris (eds.), The Genetic Basis for Alcohol and Drug Actions. New York: Plenum, pp. 105-152.
2. Barbosa, A. D., and Morato, G. S. (2000). Effect of epipregnanolone and pregnenolone sulfate on chronic tolerance to ethanol. Pharmacol. Biochem. Behav. 67:459-464.
3. Barbosa, A. D., and Morato, G. S. (2001). Influence of neurosteroids on the development of rapid tolerance to ethanol in mice. Eur. J. Pharmacol. 431:179-188.
4. Belknap, J. K., Crabbe, J. C., and Young, E. R. (1993). Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology 112:503-510.
5. Bennett, B., Beeson, M., Gordon, L., Carosone-Link, A. P., and Johnson, T. E. (2002). Genetic dissection of quantitative trait loci specifying sedative/hypnotic sensitivity to ethanol: mapping with interval-specific congenic recombinant lines. Alcohol. Clin. Exp. Res. 26:1615-1624.
6. Crabbe, J. C. (1983). Sensitivity to ethanol in inbred mice: genotypic correlations among several behavioral responses. Behav. Neurosci. 97:2-280289.
7. Crabbe, J. C. (1994). Tolerance to ethanol hypothermia in HOT and COLD mice. Alcohol. Clin. Exp. Res. 18:42-46.
8. Crabbe, J. C., Belknap, J. K., Mitchell, S. R., and Crawshaw, L. I. (1994a). Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice. J. Pharmacol. Exp. Ther. 269:184-192.
9. Crabbe, J. C., Cotnam, C. J., Cameron, A. J., Schlumbohm, J. P., Rhodes, J. S., Metten, P., and Wahlsten, D. (2003a). Strain differences in three measures of ethanol intoxication in mice, the screen, dowel and grip strength tests. Genes Brain Behav. 2:201-213.
10. Crabbe, J. C., Feller, D. J., and Dorow, J. S. (1989). Sensitivity and tolerance to ethanol-induced hypothermia in genetically selected mice. J. Pharmacol. Exp. Ther. 249:2-456461.
11. Crabbe, J. C., Gallaher, E. S., Phillips, T. J., and Belknap, J. K. (1994b). Genetic determinants of sensitivity to ethanol in inbred mice. Behav. Neurosci. 108:186-195.
12. Crabbe, J. C., Janowsky, J. S., Young, E. R., Kosobud, A., Stack, J., and Rigter, H. (1982). Tolerance to ethanol hypothermia in inbred mice: genotypic correlations with behavioral responses. Alcohol. Clin. Exp. Res. 6:4-446458.
13. Crabbe, J. C., Kosobud, A., Tam, B. R., Young, E. R., and Deutsch, C. M. (1987). Genetic selection of mouse lines sensitive (cold) and resistant (hot) to acute ethanol hypothermia. Alcohol Drug Res. 7:163-174.
14. Crabbe, J. C., Metten, P., Cameron, A. J., and Wahlsten, D. (2005). An analysis of the genetics of alcohol intoxication in inbred mice. Neurosci. Biobehav. Rev. 28:785-802.
15. Crabbe, J. C., Metten, P., Yu, C.-H., Schlumbohm, J. P., Cameron, A. J., and Wahlsten, D. (2003b). Genotypic differences in ethanol sensitivity in two tests of motor incoordination. J. Appl. Physiol. 95:1338-1351.
16. Crabbe, J. C., Phillips, T. J., Gallaher, E. J., Crawshaw, L. I., and Mitchell, S. R. (1996). Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci. J. Pharmacol. Exp. Ther. 277:624-632.
17. Crabbe, J. C., Rigter, H., Uijlen, J., and Strijbos, C. (1979). Rapid development of tolerance to the hypothermic effect of ethanol in mice. J. Pharmacol. Exp. Ther. 208:1-128133.
18. Crabbe, J. C., Wahlsten, D., and Dudek, B. C. (1999). Genetics of mouse behavior: interactions with laboratory environment. Science 284:1670-1672.
19. Crawshaw, L. I., Crabbe, J. C., and Hayteas, D. L. (1994). Temperature regulation in mice during withdrawal from ethanol dependence. Am. J. Physiol. 267:R929-R934.
20. Dixon, W. J., and Mood, A. M. (1948). A method for obtaining and analyzing sensitivity data. J. Am. Stat. Assoc. 43:109-126.
21. Draski, L. J., and Deitrich, R. A. (1996). Initial effects of ethanol on the central nervous system. In R. A. Deitrich and V. G. Erwin (eds.), Pharmacological Effects of Ethanol on the Nervous System. Boca Raton FL: CRC Press, pp. 227-250.
22. Erwin, V. G., and Deitrich, R. A. (1996). Genetic selection and characterization of mouse lines for acute functional tolerance to ethanol. J. Pharmacol. Exp. Ther. 279:1310-1317.
23. Erwin, V. G., Radcliffe, R. A., and Jones, B. C. (1992). Chronic ethanol consumption produces genotype-dependent tolerance to ethanol in LS/Ibg and SS/Ibg mice. Pharmacol. Biochem. Behav. 41:275-281.
24. Fuller, J. L. (1964). Measurement of alcohol preference in genetic experiments. J. Comp. Physiol. Psych. 57:85-88.
25. Grieve, S. J., and Littleton, J. M. (1979). Age and strain differences in the rate of development of functional tolerance to ethanol by mice. J. Pharm. Pharmacol. 31:696-700.
26. Grubb, S. C., Churchill, G. A., and Bogue, M. A. (2004). A collaborative database of inbred mouse strain characteristics. Bioinformatics 20:2857-2859.
27. Hegmann, J. P., and Possidente, B. (1981). Estimating genetic correlations from inbred strains. Behav. Genet. 11:103-114.
28. Kalant, H. (1996). Current state of knowledge about the mechanisms of alcohol tolerance. Addict. Biol. 1:133-141.
29. Kalant, H., and Lê, A. D. (1984). Effects of ethanol on thermoregulation. Pharmacol. Ther. 23:313-364.
30. Kalant, H., LeBlanc, A. E., and Gibbins, R. J. (1971). Tolerance to, and dependence on, some non-opiate psychotropic drugs. Pharmacol. Rev. 23:135-191.
31. Keir, W. J., and Deitrich, R. A. (1990). Development of central nervous system sensitivity to ethanol and pentobarbital in short-and long-sleep mice. J. Pharmacol. Exp. Ther. 254:3-831835.
32. Khanna, J. M., Kalant, H., Shah, G., and Weiner, J. (1991). Rapid tolerance as an index of chronic tolerance. Pharmacol. Biochem. Behav. 38:427-432.
33. Khanna, J. M., Kalant, H., Weiner, J., Chau, A., and Shah, G. (1992). Ketamine retards chronic but not acute tolerance to ethanol. Pharmacol. Biochem. Behav. 42:347-350.
34. Khanna, J. M., Morato, G. S., Chau, A., Shah, G., and Kalant, H. (1994). Effect of NMDA antagonists on rapid and chronic tolerance to ethanol: Importance of intoxicated practice. Pharmacol. Biochem. Behav. 48:755-763.
35. Khanna, J. M., Morato, G. S., and Kalant, H. (2002). Effect of NMDA antagonists, an NMDA agonist, and serotonin depletion on acute tolerance to ethanol. Pharmacol. Biochem. Behav. 72:291-298.
36. Mackay, T. F. (2001). The genetic architecture of quantitative traits. Annu. Rev. Genet. 35:303-339.
37. Markel, P. D., Bennett, B., Beeson, M., Gordon, L., and Johnson, T. E. (1997). Confirmation of quantitative trait loci for ethanol sensitivity in long- sleep and short-sleep mice. Genome Res. 7:92-99.
38. Markel, P. D., DeFries, J. C., and Johnson, T. E. (1995). Ethanol-induced anesthesia in inbred strains on long-sleep and short-sleep mice: A genetic analysis of repeated measures using censored data. Behav. Genet. 25(1):67-73.
39. McClearn, G. E., and Kakihana, R. (1981). Selective breeding for ethanol sensitivity: short-sleep and long-sleep mice. In G. E. McClearn, R. A. Deitrich and V. G. Erwin (eds.), Development of Animal Models as Pharmacogenetic Tools. Rockville MD: USDHHS:NIAAA, pp. 147-159.
40. McClearn, G. E., and Rodgers, D. A. (1959). Differences in alcohol preference among inbred strains of mice. Q. J. Stud. Alcohol 20:691-695.
41. Mellanby, E. (1919). Alcohol: Its Absorption into and Disappearance from the Blood under Different Conditions. London: Medical Research Committee.
42. Metten, P., Best, K. L., Cameron, A. J., Saultz, A. B., Zuraw, J. M., Yu, C.-H., Wahlsten, D., and Crabbe, J. C. (2004). Observer-rated ataxia: rating scales for assessment of genetic differences in ethanol-induced intoxication in mice. J. Appl. Physiol. 97:360-368.
43. Metten P. and Crabbe J. C. (2005). Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. Behav. Neurosci. 119:911-925.
44. Owens, J. C., Bennett, B., and Johnson, T. E. (2002). Possible pleiotropic effects of genes specifying sedative/hypnotic sensitivity to ethanol on other alcohol-related traits. Alcohol. Clin. Exp. Res. 26:1461-1467.
45. Phillips, T. J. (1997). Behavior genetics of drug sensitization. Crit. Rev. Neurobiol. 11:21-33.
46. Phillips, T. J., and Crabbe, J. C. (1991). Behavioral studies of genetic differences in alcohol action. In J. C. Crabbe and R. A. Harris (eds.), The Genetic Basis of Alcohol and Drug Actions. New York: Plenum Press, pp. 25-104.
47. Ponomarev, I., and Crabbe, J. C. (2004). Characterization of acute functional tolerance to the hypnotic effects of ethanol in mice. Alcohol. Clin. Exp. Res. 28:991-997.
48. Ponomarev, I., and Crabbe, J. C. (2002). A novel method to assess initial sensitivity and acute functional tolerance to hypnotic effects of ethanol. J. Pharmacol. Exp. Ther. 302:257-263.
49. Preacher, K. J., and MacCallum, R. C. (2002). Exploratory factor analysis in behavior genetics research: factor recovery with small sample sizes. Behav. Genet. 32:153-161.
50. Rodgers, D. A. (1972). Factors underlying differences in alcohol preference in inbred strains of mice. In B. Kissin and H. Begleiter (eds.), The Biology of Alcoholism. New York: Plenum, pp. 107-130.
51. Rustay, N. R., Boehm, S. L., Schafer, G. L., Browman, K. E., Erwin, V. G., and Crabbe, J. C. (2001). Sensitivity and tolerance to ethanol-induced incoordination and hypothermia in HAFT and LAFT mice. Pharmacol. Biochem. Behav. 70:167-174.
52. Rustay, N. R., and Crabbe, J. C. (2004). Genetic analysis of rapid tolerance to ethanol's incoordinating effects in mice: Inbred strains and artificial selection. Behav. Genet. 34:441-451.
53. Rustay, N. R., Wahlsten, D., and Crabbe, J. C. (2003). Assessment of genetic susceptibility to ethanol intoxication in mice. Proc. Nat. Acad. Sci. USA 100:2917-2922.
54. Schuckit, M. A. (1994). Low level of response to alcohol as a predictor of future alcoholism. Am. J. Psychiat. 151: 184-189.
55. Schuckit, M. A., Smith, T. L., and Kalmijn, J. (2004). The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. Alcohol. Clin. Exp. Res. 28:1449-1458.
56. Sokal, R. R., and Rohlf, F. J. (1981). Biometry. Freeman: San Francisco.
57. Wahlsten, D., Metten, P., and Crabbe, J. C. (2003a). A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain Behav. 2:71-79.
58. Wahlsten, D., Metten, P., Phillips, T. J., Boehm, S. L. II, Burkhart-Kasch, S., Dorow, J., Doerksen, S., Downing, C., Fogarty, J., Rodd-Henricks, K., Hen, R., McKinnon, C. S., Merrill, C. M., Nolte, C., Schalomon, M., Schlumbohm, J. P., Sibert, J. R., Wenger, C. D., Dudek, B. C., and Crabbe, J. C. (2003b). Different data from different labs: lessons from studies of gene-environment interaction. J. Neurobiol. 54:283-311.