Metabolite 1 of protopanaxadiol-type saponins, an axonal regenerative factor, stimulates teneurin-2 linked by PI3-kinase cascade

Neuropsychopharmacology

Volumn 31, Issue 6, 2006, Pages 1158-1164

  Tohda, Chihiro ^a   Hashimoto, Itsuki ^a   Kuboyama, Tomoharu ^a   Komatsu, Katsuko ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Axon; Ginseng; M1; mPar3; Synapse; Teneurin 2

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 20 O BETA DEXTRO GLUCOPYRANOSYL 20 PROTOPANAXADIOL; AMYLOID BETA PROTEIN[25-35]; CELL SURFACE PROTEIN; GINSENOSIDE RD; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN MPAR3; PROTOPANAXADIOL; RNA; SAPONIN; SMALL INTERFERING RNA; TENEURIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG TARGETING; EMBRYO; ENZYME ACTIVATION; FEMALE; GINSENG; IMMUNOPRECIPITATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SILVER STAINING; SYNAPSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMYLOID BETA-PROTEIN; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MORPHOLINES; NEURITES; NEURONS; PEPTIDES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SAPOGENINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSFECTION; TRITERPENES;

EID: 33745641914     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300943     Document Type: Article

References (19)

1. Bagutti C, Forro G, Ferralli J, Rubin B, Chiquet-Ehrismann R (2003). The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription. J Cell Sci 116: 2957-2966.
2. Edström A, Ekström PA (2003). Role of phosphatidylinositol 3-kinase in neuronal survival and axonal outgrowth of adult mouse dorsal root ganglia explants. J Neurosci Res 74: 726-735.
3. Klesse LJ, Parada LF (1999). Trks: signal transduction and intracellular pathways. Microsc Res Tech 45: 210-216.
4. Lee SJ, Sung JH, Lee SJ, Moon CK, Lee BH (1999). Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin. Cancer Lett 144: 39-43.
5. Levine A, Bashan-Ahrend A, Budai-Hadrian O, Gartenberg D, Menasherow S, Wides R (1994). Odd Oz: a novel Drosophila pair rule gene. Cell 77: 587-598.
6. Menager C, Arimura N, Fukata Y, Kaibuchi K (2004). PIP3 is involved in neuronal polarization and axon formation. J Neurochem 9: 109-118.
7. Minet AD, Chiquet-Ehrismann R (2000). Phylogenetic analysis of teneurin genes and comparison to the rearrangement hot spot elements of E. coli. Gene 257: 87-97.
8. 1 in the rat. Chem Pharm Bull 31: 1059-1066.
9. Otaki JM, Firestein S (1999). Neurestin: putative transmembrane molecule implicated in neuronal development. Dev Biol 212: 165-181.
10. Rodgers EE, Theibert AB (2002). Functions of PI3-kinase in development of the nervous system. Int Dev Neurosci 20: 187-197.
11. Rubin BP, Tucker RP, Brown-Luedi M, Martin D, Chiquet-Ehrismann R (2002). Teneurin 2 is expressed by the neurons of the thalamofugal visual system in situ and promotes homophilic cell-cell adhesion in vitro. Development 129: 4697-4705.
12. Rubin BP, Tucker RP, Martin D, Chiquet-Ehrismann R (1999). Teneurins: a novel family of neuronal cell surface proteins in vertebrates, homologous to the Drosophila pair-rule gene product Ten-m. Dev Biol 216: 195-209.
13. Schwamborn JC, Püschel AW (2004). The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity. Nat Neurosci 7: 923-929.
14. Shi SH, Jan LY, Jan YN (2003). Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell 112: 63-75.
15. Tawab MA, Bahr U, Karas M, Wurglics M, Schubert-Zsilavecz M (2003). Degeneration of ginsenosides in humans after oral administration. Drug Metab Dispos 31: 1065-1071.
16. Tohda C, Matsumoto N, Zou K, Meselhy MR, Komatsu K (2004). Aβ (25-35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins. Neuropsychopharmacology 29: 860-868.
17. Tohda C, Matsumoto N, Zou K, Meselhy RM, Komatsu K (2002). Axonal and dendritic extension by protopanaxadiol-type saponins from ginseng drugs in SK-N-SH cells. Jpn J Pharmacol 90: 254-262.
18. Tucker RP, Chiquet-Ehrismann R, Chevron MP, Martin D, Hall RJ, Rubin BP (2001). Teneurin-2 is expressed in tissues that regulate limb and somite pattern formation and is induced in vitro and in situ by FGF8. Dev Dyn 220: 27-39.
19. Wakabayashi C, Murakami K, Hasegawa H, Murata J, Saiki I (1998). An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem Biophys Res Commun 246: 725-730.