Adenosine A2A receptor mediated protective effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on retinal ischaemia/reperfusion damage in rats

British Journal of Ophthalmology

Volumn 90, Issue 7, 2006, Pages 900-905

  Konno, Takashi ^a   Sato, A ^a   Uchibori, T ^a   Nagai, A ^a   Kogi, K ^a   Nakahata, N ^b  

^a TOA EIYO LTD   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (6 CYANO 1 HEXYN 1 YL)ADENOSINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 P(2 CARBOXYETHYL)PHENETHYLAMINO 5' N ETHYLCARBOXAMIDOADENOSINE; 8 (3 CHLOROSTYRYL)CAFFEINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE A2B RECEPTOR ANTAGONIST; DIZOCILPINE; FLAVINE MONONUCLEOTIDE; UNCLASSIFIED DRUG; 2-(6-CYANO-1-HEXYN-1-YL)ADENOSINE; ADENOSINE; AMINO ACID RECEPTOR BLOCKING AGENT; ANTIHYPERTENSIVE AGENT; DIZOCILPINE MALEATE; DRUG DERIVATIVE; PHENETHYLAMINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; EYE PROTECTION; HISTOPATHOLOGY; INTRAOCULAR PRESSURE; MALE; NONHUMAN; NUCLEAR LAMINA; PRESSURE TRANSDUCER; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; REPERFUSION INJURY; RETINA GANGLION CELL; RETINA ISCHEMIA; ANIMAL; CHEMISTRY; DRUG POTENTIATION; ISCHEMIC PRECONDITIONING; METABOLISM; PATHOLOGY; RETINA BLOOD VESSEL; SPRAGUE DAWLEY RAT; TOPICAL DRUG ADMINISTRATION;

ADENOSINE; ADMINISTRATION, TOPICAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; INTRAOCULAR PRESSURE; ISCHEMIC PRECONDITIONING; MALE; PHENETHYLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A2A; REPERFUSION INJURY; RETINAL VESSELS;

EID: 33745640024     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.2006.091496     Document Type: Article

References (32)

1. Weber M, Bonaventure N, Sahel JA. Protective role of excitatory amino acid antagonists in experimental retinal ischemia. Graefes Arch Clin Exp Ophthalmol 1995;233:360-5.
2. Lam TT, Siew E, Chu R, et al. Ameliorative effect of MK-801 on retinal ischemia. J Ocul Pharmacol Ther 1997;13:129-37.
3. Ffythce TJ. A rationalization of treatment of central retinal artery occlusion. Trans Ophthal Soc UK 1974;94:468-79.
4. Kaushik S, Pandav SS, Ram J. Neuroprotection in glaucoma. J Postgrad Med 2003;49:90-5.
5. Osborne NN, Melena J, Chidlow G, et al. A hypothesis to explain ganglion cell death caused by vascular insults at the optic nerve head: possible implication for the treatment of glaucoma. Br J Ophthalmol 2001;85:1252-9.
6. Braunagel SC, Xiao JG, Chiou GC. The potential role of adenosine in regulating blood flow in the eye. J Ocul Pharmacol 1988;4:61-73.
7. Blazynski C, Perez MT. Adenosine in vertebrate retina: localization, receptor characterization, and function. Cell Mol Neurobiol 1991;11:463-84.
8. Polska E, Ehrlich P, Luksch A, et al. Effects of adenosine on intraocular pressure, optic nerve head blood flow, and choroidal blood flow in healthy humans. Invest Ophthalmol Vis Sci 2003;44:3110-14.
9. Ghiardi GJ, Gidday JM, Roth S. The purine nucleoside adenosine in retinal ischemia-reperfusion injury. Vis Res 1999;39:2519-35.
10. Roth S, Park SS, Sikorski CW, et al. Concentrations of adenosine and its metabolites in the rat retina/choroid during reperfusion after ischemia. Curr Eye Res 1997;16:875-85.
11. Roth S, Rosenbaum PS, Osinski J, et al. Ischemia induces significant changes in purine nucleoside concentration in the retina-choroid in rats. Exp Eye Res 1997;65:771-9.
12. Larsen AK, Osborne NN. Involvement of adenosine in retinal ischemia. Studies on the rat. Invest Ophthalmol Vis Sci 1996;37:2603-11.
13. Li B, Rosenbaum PS, Jennings NM, et al. Differing roles of adenosine receptor subtypes in retinal ischemia-reperfusion injury in the rat. Exp Eye Res 1999;68:9-17.
14. Li B, Roth S. Retinal ischemic preconditioning in the rat: requirement for adenosine and repetitive induction. Invest Ophthalmol Vis Sci 1999;40:1200-16.
15. 2a receptors blocks glutamate excitotoxicity in cultures of avian retinal neurons. Brain Res 2001;900:169-76.
16. 2A receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells. Exp Eye Res 2000;70:577-87.
17. Matsudo A, Shinozaki M, Yamaguchi T, et al. Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects. J Med Chem 1992;35:241-52.
18. Konno T, Murakami A, Uchibori T, et al. Involvement of adenosine A(2a) receptor in intraocular pressure decrease induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-cyano-1-hexyn-1-yl)adenosine. J Pharmacol Sci 2005;97:501-9.
19. Konno T, Ohnuma S, Uemoto K, et al. Effects of 2-alkynyladenosine derivatives on intraocular pressure in rabbits. Eur J Pharmacol 2004;486:307-16.
20. 2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rat retina. Exp Eye Res 2000;70:475-84.
21. Stefansson E, Wilson CA, Schoen T, et al. Experimental ischemia induces cell mitosis in the adult rat retina. Invest Ophthalmol Vis Sci 1988;29:1050-5.
22. Seki M, Tanaka T, Matsuda H, et al. Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model. Br J Ophthalmol 2005;89:504-7.
23. Osborne NN, Casson RJ, Wood JP, et al. Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Prog Retin Eye Res 2004;23:91-147.
24. Pop E. Trends in neuroprotection. Arch Soc Esp Oftalmol 2002;77:295-7.
25. Campochiaro PA, Sen HA. Adenosine and its agonists cause retinal vasodilation and hemorrhages. Implications for ischemic retinopathies. Arch Ophthalmol 1989;107:412-16.
26. Gidday JM, Park TS. Microcirculatory responses to adenosine in the newborn pig retina. Pediatr Res 1993;33:620-7.
27. Matsugi T, Chen Q, Anderson DR. Adenosine-induced relaxation of cultured bovine retinal pericytes. Invest Ophthalmol Vis Sci 1997;38:2695-701.
28. 2A receptors, nitric oxide, and KATP channels in retinal arteriolar dilation in response to adenosine. Invest Ophthalmol Vis Sci 2005;46:2113-9.
29. Paul S, Feoktistov I, Hollister AS, et al. Adenosine inhibits the rise in intracellular calcium and platelet aggregation produced by thrombin: evidence that both effects are coupled to adenylate cyclase. Mol Pharmacol 1990;37:870-5.
30. 2A receptor agonists as anti-inflammatory agents. Curr Opin Investig Drugs 2003;4:1313-19.
31. Kogi K, Uchibori T, Aihara K, et al. Pharmacological profile of the 2-alkynyladenosine derivative 2-octynyladenosine (YT-146) in the cardiovascular system. Jpn J Pharmacol 1991;57:153-65.
32. 2A receptor agonists reduce ischemia/reperfusion injury of rat liver mainly by inhibiting leukocyte activation. J Pharmacol Exp Ther 2000;294:1034-42.