Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3

Journal of Cell Biology

Volumn 174, Issue 1, 2006, Pages 19-25

  Lam, Karen K Y ^a   Davey, Michael ^a   Sun, Beimeng ^b   Roth, Amy F ^b   Davis, Nicholas G ^b   Conibear, Elizabeth ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ASPARTYLHISTIDYLHISTIDYLCYSTEINE; CHAPERONE; CHITIN SYNTHASE; MEMBRANE PROTEIN; PROTEIN ACYLTRANSFERASES; PROTEIN CHS3; PROTEIN CHS7; PROTEIN PFA4; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVITY; CELL SURFACE; ENDOPLASMIC RETICULUM; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; YEAST;

ACYLTRANSFERASES; ENDOPLASMIC RETICULUM; PALMITIC ACID; PROTEIN PROCESSING, POST-TRANSLATIONAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 33745623380     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200602049     Document Type: Article

References (31)

1. Bijlmakers, M.J., and M. Marsh. 2003. The on-off story of protein palmitoylation. Trends Cell Biol. 13:32-42.
2. Conibear, E., and T.H. Stevens. 2000. Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi. Mol. Biol. Cell. 11:305-323.
3. Conibear, E., and T.H. Stevens. 2002. Studying yeast vacuoles. Methods Enzymol. 351:408-432.
4. Cos, T., R.A. Ford, J.A. Trilla, A. Duran, E. Cabib, and C. Roncero. 1998. Molecular analysis of Chs3p participation in chitin synthase III activity. Eur. J. Biochem. 256:419-426.
5. Drisdel, R.C., and W.N. Green. 2004. Labeling and quantifying sites of protein palmitoylation. Biotechniques. 36:276-285.
6. Drisdel, R.C., E. Manzana, and W.N. Green. 2004. The role of palmitoylation in functional expression of nicotinic alpha7 receptors. J. Neurosci. 24:10502-10510.
7. Gilstring, C.F., M. Melin-Larsson, and P.O. Ljungdahl. 1999. Shr3p mediates specific COPII coatomer-cargo interactions required for the packaging of amino acid permeases into ER-derived transport vesicles. Mol. Biol. Cell. 10:3549-3565.
8. Hou, H., K. Subramanian, T.J. LaGrassa, D. Markgraf, L.E. Dietrich, J. Urban, N. Decker, and C. Ungermann. 2005. The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8. Proc. Natl. Acad. Sci. USA. 102:17366-17371.
9. Keller, C.A., X. Yuan, P. Panzanelli, M.L. Martin, M. Alldred, M. Sassoe-Pognetto, and B. Luscher. 2004. The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ. J. Neurosci. 24:5881-5891.
10. Kota, J., and P.O. Ljungdahl. 2005. Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER. J. Cell Biol. 168:79-88.
11. Lesage, G., A.M. Sdicu, P. Menard, J. Shapiro, S. Hussein, and H. Bussey. 2004. Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin. Genetics. 167:35-49.
12. Levine, T.P., C.A. Wiggins, and S. Munro. 2000. Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae. Mol. Biol. Cell. 11:2267-2281.
13. Lobo, S., W.K. Greentree, M.E. Linder, and R.J. Deschenes. 2002. Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae. J. Biol. Chem. 277:41268-41273.
14. Longtine, M.S., A. McKenzie III, D.J. Demarini, N.G. Shah, A. Wach, A. Brachat, P. Philippsen, and J.R. Pringle. 1998. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast. 14:953-961.
15. Malkus, P., L.A. Graham, T.H. Stevens, and R. Schekman. 2004. Role of Vma21p in assembly and transport of the yeast vacuolar ATPase. Mol. Biol. Cell. 15:5075-5091.
16. Meusser, B., C. Hirsch, E. Jarosch, and T. Sommer. 2005. ERAD: the long road to destruction. Nat. Cell Biol. 7:766-772.
17. Mitchell, D.A., A. Vasudevan, M.E. Linder, and R.J. Deschenes. 2006. Protein palmitoylation by a family of DHHC protein S-acyltransferases. J. Lipid Res. 47:1118-1127.
18. Politis, E.G., A.F. Roth, and N.G. Davis. 2005. Transmembrane topology of the protein palmitoyl transferase Akr1. J. Biol. Chem. 280:10156-10163.
19. Roncero, C. 2002. The genetic complexity of chitin synthesis in fungi. Curr. Genet. 41:367-378.
20. Roncero, C., and A. Duran. 1985. Effect of Calcofluor white and Congo red on fungal cell wall morphogenesis: in vivo activation of chitin polymerization. J. Bacteriol. 163:1180-1185.
21. Roth, A.F., Y. Feng, L. Chen, and N.G. Davis. 2002. The yeast DHHC cysteinerich domain protein Akr1p is a palmitoyl transferase. J. Cell Biol. 159:23-28.
22. Roth, A.F., J. Wan, A.O. Bailey, B. Sun, J.A. Kuchar, W.N. Green, B.S. Phinney, J.R. Yates III, and N.G. Davis. 2006. Global analysis of protein palmitoylation in yeast. Cell. 125:1003-10013.
23. Schulein, R. 2004. The early stages of the intracellular transport of membrane proteins: clinical and pharmacological implications. Rev. Physiol. Biochem. Pharmacol. 151:45-91.
24. Sheff, M.A., and K.S. Thorn. 2004. Optimized cassettes for fluorescent protein tagging in Saccharomyces cerevisiae. Yeast. 21:661-670.
25. Smotrys, J.E., M.J. Schoenfish, M.A. Stutz, and M.E. Linder. 2005. The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. J. Cell Biol. 170:1091-1099.
26. Tong, A.H., M. Evangelista, A.B. Parsons, H. Xu, G.D. Bader, N. Page, M. Robinson, S. Raghibizadeh, C.W. Hogue, H. Bussey, et al. 2001. Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science. 294:2364-2368.
27. Trilla, J.A., A. Duran, and C. Roncero. 1999. Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae. J. Cell Biol. 145:1153-1163.
28. Valdez-Taubas, J., and H. Pelham. 2005. Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation. EMBO J. 24:2524-2532.
29. Valdivia, R.H., and R. Schekman. 2003. The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane. Proc. Natl. Acad. Sci. USA. 100:10287-10292.
30. Ziman, M., J.S. Chuang, and R.W. Schekman. 1996. Chs1p and Chs3p, two proteins involved in chitin synthesis, populate a compartment of the Saccharomyces cerevisiae endocytic pathway. Mol. Biol. Cell. 7:1909-1919.
31. Ziman, M., J.S. Chuang, M. Tsung, S. Hamamoto, and R. Schekman. 1998. Chs6p-dependent anterograde transport of Chs3p from the chitosome to the plasma membrane in Saccharomyces cerevisiae. Mol. Biol. Cell. 9:1565-1576.