Design, synthesis and initial in vitro evaluation of novel prodrugs for the treatment of cystinosis

Letters in Drug Design and Discovery

Volumn 3, Issue 5, 2006, Pages 336-345

  Anderson, R J ^a   Cairns, D ^a,d   Cardwell, W A ^a   Case, M ^b   Groundwater, P W ^a   Hall, A G ^b   Hogarth, L ^b   Jones, A L ^c   Meth Cohn, O ^a   Suryadevara, P ^a   Tindall, A ^a   Thoene, J G ^c  

^a UNIVERSITY OF SUNDERLAND   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ROBERT GORDON UNIVERSITY   (United Kingdom)

Author keywords

Cystamine; Cysteamine; Cystinosis; GGT; Prodrugs

Indexed keywords

AMINE; CYSTAMINE DERIVATIVE; CYSTEAMINE DERIVATIVE; GAMMA GLUTAMYLTRANSFERASE; N PHENYLALANYLCYSTEAMINE TRIFLUOROACETATE; N TYROSYLCYSTEAMINE TRIFLUOROACETATE; N(ALPHA GLUTAMYL)CYSTEAMINE TRIFLUOROACETATE; N(CALPHA BENZYL GAMMA GLUTAMYL)CYSTEAMINE TRIFLUOROACETATE; N(GAMMA GLUTAMYL)CYSTEAMINE TRIFLUOROACETATE; N,N(BIS ALANYL)CYSTAMINE BISTRIFLUOROACETATE; N,N(BIS ALPHA GLUTAMYL)CYSTAMINE BISTRIFLUOROACETATE; N,N(BIS GAMMA GLUTAMYL)CYSTAMINE BISTRIFLUOROACETATE; N,N(BIS GLYCYL)CYSTAMINE BISTRIFLUOROACETATE; N,N(BIS PHENYLALANYL)CYSTAMINE BISTRIFLUOROACETATE; N,N(BIS TYROSYL)CYSTAMINE BISTRIFLUOROACETATE; N,N[BIS(CALPHA BENZYL GAMMA GLUTAMYL)]CYSTAMINE BISTRIFLUOROACETATE; PRODRUG; THIOL GROUP; UNCLASSIFIED DRUG;

ARTICLE; CYSTINOSIS; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; GASTROINTESTINAL IRRITATION; GASTROINTESTINAL SYMPTOM; HALITOSIS; HUMAN; IN VITRO STUDY; LD 50; NAUSEA; NONHUMAN; PALATABILITY; PRIORITY JOURNAL;

EID: 33745618138     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018006777574258     Document Type: Article

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