Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5699-5710

  George, Tesmol G ^a   Johnsamuel, Jayaseharan ^a   Delfín, Dawn A ^a   Yakovich, Adam ^a   Mukherjee, Mitali ^a   Phelps, Mitch A ^a   Dalton, James T ^a   Sackett, Dan L ^b   Kaiser, Marcel ^c   Brun, Reto ^c   Werbovetz, Karl A ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Chemotherapy; Dinitroaniline; Leishmania; Trypanosome; Tubulin

Indexed keywords

BENZAMIDE DERIVATIVE; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; IC 50; NONHUMAN; PARASITE; PURIFICATION; RAT; TRYPANOSOMA;

ANIMALS; ANTIMITOTIC AGENTS; ANTIPROTOZOAL AGENTS; BENZAMIDES; INHIBITORY CONCENTRATION 50; KINETOPLASTIDA; LEISHMANIA DONOVANI; LIVER; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFANILAMIDES; TRYPANOSOMA; TUBULIN;

KINETOPLASTIDA;

EID: 33745611775     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.017     Document Type: Article

References (26)

1. Croft S., Barrett M., and Urbina J. Trends Parasitol. 21 (2005) 508-512
2. Dow G., Armson A., Boddy M., Itenge T., McCarthy D., Parkin J., Thompson R., and Reynoldson J. Exp. Parasitol. 100 (2002) 155-160
3. Stokkermans T., Schwartzman J., Keenan K., Morrissette N., Tilney L., and Roos D. Exp. Parasitol. 84 (1996) 355-370
4. Benbow J., Bernberg E., Korda A., and Mead J. Antimicrob. Agents Chemother. 42 (1998) 339-343
5. Chan M., Triemer R.E., and Fong D. Differentiation 46 (1991) 15-21
6. Chan M., Grogl M., Chen C.-C., Bienen E.J., and Fong D. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 5657-5661
7. Callahan H.L., Kelley C., Pereira T., and Grogl M. Antimicrob. Agents Chemother. 40 (1996) 947-952
8. Bhattacharya G., Salem M., and Werbovetz K. Bioorg. Med. Chem. Lett. 12 (2002) 2395-2398
9. Traub-Cseko Y., Ramalho-Ortigao J., Dantas A., de Castro S., Barbosa H., and Downing K. Trends Parasitol. 17 (2001) 136-141
10. Morrissette N., Mitra A., Sept D., and Sibley L. Mol. Biol. Cell 15 (2004) 1960-1968
11. Fennell B., Naughton J., Dempsey E., and Bell A. Mol. Biochem. Parasitol. 145 (2006) 226-238
12. Chan M., and Fong D. Science 249 (1990) 924-926
13. Werbovetz K., Sackett D., Delfin D., Bhattacharya G., Salem M., Obrzut T., Rattendi D., and Bacchi C. Mol. Pharmacol. 64 (2003) 1325-1333
14. Bhattacharya G., Herman J., Delfin D., Salem M., Barszcz T., Mollet M., Riccio G., Brun R., and Werbovetz K. J. Med. Chem. 47 (2004) 1823-1832
15. Wu, D.; George, T.; Hurh, E.; Werbovetz, K.; Dalton, J. Life Sci., in press.
16. Dubowchik G., Michne J., and Zuev D. Bioorg. Med. Chem. Lett. 14 (2004) 3147-3149
17. Schultz H. 2,6-Dinitroaniline. In: Rabjohn N. (Ed). Organic Syntheses (1963), John Wiley, New York 364-366
18. Hamel E. Cell Biochem. Biophys. 38 (2003) 1-22
19. Groom C., Thillet J., North A., Pictet R., and Geddes A. J. Biol. Chem. 266 (1991) 19890-19893
20. Wyss P., Gerber P., Hartman P., Hubschwerlen C., Locher H., Marty H., and Stahl M. J. Med. Chem. 46 (2003) 2304-2312
21. Selassie C., Gan W., Kallander L., and Klein T. J. Med. Chem. 41 (1998) 4261-4272
22. Werbovetz K., Brendle J., and Sackett D. Mol. Biochem. Parasitol. 98 (1999) 53-65
23. Pez D., Leal I., Zuccotto F., Boussard C., Brun R., Croft S., Yardley V., RuizPerez L., Gonzalez Pacanowska D., and Gilbert I. Bioorg. Med. Chem. 11 (2003) 4693-4711
24. Heilmann J., Brun R., Mayr S., Rali T., and Sticher O. Phytochemistry 57 (2001) 1281-1285
25. Salem M., and Werbovetz K. J. Nat. Prod. 68 (2005) 108-111
26. Stephens C., Brun R., Salem M., Werbovetz K., Tanious F., Wilson W., and Boykin D. Bioorg. Med. Chem. Lett. 13 (2003) 2065-2069