Time- and dose-response effects of the mycotoxin, fumonisin B1 on sphingoid base elevations in precision-cut rat liver and kidney slices

Toxicology in Vitro

Volumn 10, Issue 3, 1996, Pages 349-358

  Norred, W P ^a   Riley, R T ^a   Meredith, F I ^a   Bacon, C W ^a   Voss, K A ^a  

^a RUSSELL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUMONISIN B1; MYCOTOXIN; SPHINGANINE; SPHINGOLIPID;

ANIMAL TISSUE; ARTICLE; BIOASSAY; CONTROLLED STUDY; CORN; DOSE TIME EFFECT RELATION; KIDNEY SLICE; LIPOGENESIS; LIVER SLICE; LIVER TOXICITY; MALE; NEPHROTOXICITY; NONHUMAN; RAT;

ANIMALIA; FUNGI; FUSARIUM; GIBBERELLA FUJIKUROI; SPHINGIODEA; ZEA MAYS;

EID: 0029954708     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/0887-2333(96)00013-6     Document Type: Article

References (32)

1. Azri S., Gandolfi A. J. and Brendel K. (1990) Precision-cut liver slices: an in vitro system for profiling potential hepatotoxicants. In Vitro Toxicology 3, 309-320.
2. 1, a mycotoxin produced on corn by Fusarium moniliforme. Contemporary Topics in Laboratory Animal Science 32, 26-28.
3. 1, in rats. Carcinogenesis 12, 1247-1251.
4. 1 on rat hepatocytes in primary culture. Carcinogenesis 16, 625-631.
5. Harrison L. R., Colvin B. M., Greene J. T., Newman L. E. and Cole J. R. (1990) Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme. Journal of Veterinary Diagnostic Investigation 2, 217-221.
6. Hassanin N. and Gabal M. A. (1990) Biological and chemical characterization of metabolites of Fusarium moniliforme isolates. Veterinary and Human Toxicology 32, 536-540.
7. Krumdieck C. L., Dos Santos J. E. and Ho K.-J. (1980) A new instrument for the rapid preparation of tissue slices. Analytical Biochemistry 104, 118-123.
8. Mandala S. M., Thornton R. A., Fromer B. R., Curotto J. E., Rozdilsky W., Kurtz M. B., Giacobbe R. A., Bills G. F., Cabello M. A., Martin I., Pelaez F. and Harris G. H. (1995) The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporormiella australis. Journal of Antibiotics 48, 349-356.
9. Marasas W. F. O., Kellerman T. S., Gelderblom W. C. A., Coetzer J. A. W., Thiel P. G. and van der Lugt J. J. (1988) Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort Journal of Veterinary Research 55, 197-203.
10. 1 from rice culture. Journal of Agricultural and Food Chemistry 44, 195-198.
11. Merrill A. H., Jr (1991) Cell regulation by sphingosine and more complex sphingolipids. Journal of Bioenergetics and Biomembranes 23, 83-104.
12. Merrill A. H., Jr, Schmelz E.-M., Wang E., Schroeder J. J., Dillehay D. L. and Riley R. T. (1995) Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases. Journal of Nutrition 125, 1677S-1682S.
13. Merrill A. H., Jr, Wang E., Gilchrist D. G. and Riley R. T. (1993a) Fumonisins and other inhibitors of de novo sphingolipid biosynthesis. Advances in Lipid Research 26, 215-231.
14. Merrill A. H., Jr, Wang E. and Riley R. T. (1993b) Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination. Official Gazette of the United States Patent and Trademark Office 1153, 384.
15. 1 in male Sprague-Dawley rats. Natural Toxins 1, 341-346.
16. Norred W. P., Wang E., Yoo H., Riley R. T. and Merrill A. H., Jr (1992) In vitro toxicology of fumonisins and the mechanistic implications. Mycopathologia 117, 73-78.
17. Pestka J. J., Azcona-Olivera J. L., Plattner R. D., Minervini F., Doko M. B. and Visconti A. (1994) Comparative assessment of fumonisin in grain-based foods by ELISA, GC-MS, and HPLC. Journal of Food Protection 57, 169-172.
18. Riley R. T., An N.-H., Showker J. L., Yoo H.-S., Norred W. P., Chamberlain W. J., Wang E., Merrill A. H., Jr, Motelin G., Beasley V. R. and Haschek W. M. (1993a) Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker in pigs of exposure to fumonisin-containing feeds. Toxicology and Applied Pharmacology 118, 105-112.
19. Riley R. T., Hinton D. M., Chamberlain W. J., Bacon C. W., Merrill A. H. and Voss K. A. (1993b) Fumonisin (FB) inhibition of sphingolipid (SL) biosynthesis: a new mechanism of nephrotoxicity. Toxicologist 13, 133.
20. 1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity. Journal of Nutrition 124, 594-603.
21. Riley R. T., Voss K. A., Yoo H. S., Gelderblom W. C. A. and Merrill A. H., Jr (1994b) Mechanism of fumonisin toxicity and carcinogenesis. Journal of Food Protection 57, 638-645.
22. Riley R. T., Wang E. and Merrill A. H., Jr (1995) Liquid Chromatographic determination of sphinganine and sphingosine: use of the free sphinganine-to-sphingosine ratio as a biomarker for consumption of fumonisins. Journal of the Association of Official Analytical Chemists International 77, 533-540.
23. 1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme. Journal of Biological Chemistry 269, 3475-3481.
24. Stevens V. L., Nimkar S., Jamison W. C., Liotta D. C. and Merrill A. H., Jr (1990) Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for involvement of protein kinase C. Biochemica et Biophysica Acta 1051, 37-45.
25. Voss K. A., Chamberlain W. J., Bacon C. W. and Norred W. P. (1993) A preliminary investigation on renal and hepatic toxicity in rats fed purified fumonisin B1. Natural Toxins 1, 222-228.
26. 1 in B6C3F1 mice and Fischer 344 rats. Fundamental and Applied Toxicology 24, 102-110.
27. Voss K. A., Norred W. P., Plattner R. D. and Bacon C. W. (1989) Hepatotoxicity and renal toxicity in rats of corn samples associated with field cases of equine leukoencephalomalacia. Food and Chemical Toxicology 27, 89-96.
28. Wang E., Norred W. P., Bacon C. W., Riley R. T. and Merrill A. H., Jr (1991) Inhibition of sphingolipid biosynthesis by fumonisins: implications for diseases associated with Fusarium moniliforme. Journal of Biological Chemistry 266, 14486-14490.
29. Wang E., Ross P. F., Wilson T. M., Riley R. T. and Merrill A. H., Jr (1992) Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme. Journal of Nutrition 122, 1706-1716.
30. Wróblewski F. and LaDue J. S. (1955) Lactic dehydrogenase activity in blood. Proceedings of the Society for Experimental Biology and Medicine 90, 210-213.
31. 1. Toxicology in Vitro 10, 77-84.
32. Yoo H., Norred W. P., Wang E., Merrill A. H., Jr and Riley R. T. (1992) Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. Toxicology and Applied Pharmacology 113, 9-15.