Effect of low dose mono-ortho 2,3′,4,4′,5 pentachlorobiphenyl on thyroid hormone status and EROD activity in rat offspring: Consequences for risk assessment

Toxicology

Volumn 186, Issue 1-2, 2003, Pages 11-20

  Kuriyama, Sergio ^a   Fidalgo Neto, Antonio ^b   Mathar, Wolfgang ^c   Palavinskas, Richard ^c   Friedrich, Karen ^a   Chahoud, Ibrahim ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c Fed Inst Hlth Protect C   (Germany)

Author keywords

EROD; Low dose; PCB 118; Perinatal exposure; Thyroid; Toxic equivalency factor

Indexed keywords

2,3',4,4',5 PENTACHLOROBIPHENYL; AROMATIC HYDROCARBON RECEPTOR; BIOLOGICAL MARKER; ETHOXYRESORUFIN DEETHYLASE; POLYCHLORINATED BIPHENYL DERIVATIVE; THYROTROPIN; THYROXINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXPOSURE; FEEDING; FEMALE; HOMEOSTASIS; HORMONE DETERMINATION; HUMAN; HUMAN CELL; HYPOPHYSIS THYROID SYSTEM; LACTATION; LIVER; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROGENY; RAT; RISK ASSESSMENT; THYROID DISEASE; THYROID RESISTANCE SYNDROME; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TISSUE DISTRIBUTION; TOXICITY;

ADIPOSE TISSUE; ANIMALS; ANIMALS, NEWBORN; CYTOCHROME P-450 CYP1A1; FEMALE; LIVER; MALE; MICROSOMES, LIVER; ORGAN SIZE; POLYCHLORINATED BIPHENYLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT; THYROID GLAND; THYROID HORMONES; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

ERAGROSTIS TEF;

EID: 0037447625     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00602-9     Document Type: Article

References (23)

1. Bosveld A.T., Kennedy S.W., Seinen W., van den Berg M. Ethoxyresorufin-O-deethylase (EROD) inducing potencies of planar chlorinated aromatic hydrocarbons in primary cultures of hepatocytes from different developmental stage of the chicken. Arch. Toxicol. 71:(12):1997;746-750.
2. Brouwer A., Morse D.C., Lans M.C., Schuur A.G., Murk A.J., Klasson-Wehler E., Bergman A., Visser T.J. Interaction of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health. Toxicol. Ind. Health. 14:(1/2):1998;59-84.
3. Burke M.D., Thompson S., Elcombe C.R., Halpert J., Haaparanta T., Mayer R.T. Ethoxy-pentoxy- and benzyloxyphenoxazones and homologues: a serie of substrates to distinguish between different induced cytochrome (s) P450. Biochem. Pharmacol. 34:1985;3337-3345.
4. Chu I., Villeneuve D.C., Yagminas A., Lecavalier P., Hakansson H., Ahlborg U.G., Valli V.E., Kennedy S.W., Bergman A., Seegal R.F., Feeley M. Toxicity of PCB 77 (3,3′,4,4′- Tetrachlorobiphenyl) and PCB 118 (2,3′,4,4′5-Pentachlorobiphenyl) in the rat following subchronic dietary exposure. Fundam. App. Toxicol. 26:1995;282-292.
5. Davenport J.W., Hennies R.S. Perinatal hypothyroidism in rats: persistent motivational and metabolic effects. Dev. Psychobiol. 9:(1):1976;67-82.
6. Demers A., Ayotte P., Brisson J., Dodin S., Robert J., Dewailly E. Plasma concentrations of polychlorinated biphenyls and the risk of breast cancer: a congener-specific analysis. Am. J. Epidemiol. 155:(7):2002;629-635.
7. Desaulniers D., Leingartner K., Wade M., Fintelman E., Yagminas A., Foster W.G. Effects of acute exposure to PCBs 126 and 153 on anterior pituitary and thyroid hormones and FSH isoforms in adult Sprague-Dawley male rats. Toxicol. Sci. 47:1999;158-169.
8. Desaulniers D., Poon R., Phan W., Leingartner K., Foster W.G., Chu I. Reproductive and thyroid hormone levels in rats following 90-day dietary exposure to PCB 28 (2,4,4-trichlorobiphenyl) or PCB 77 (3,3,4,4-tetrachlorobiphenyl). Toxicol. Indust. Health. 13:1997;627-638.
9. Environmental Health in Europe No. 3. Level of PCBs, PCDDs and PCDFs in human milk. Second round of WHO-coordinated exposure study (1996).
10. Fischer L.J., Seegal R.F., Ganey P.E., Pessah I.N., Kodavanti P.R.S. Symposium overview: toxicity of non-coplanar PCBs. Toxicol. Sci. 41:1998;49-61.
11. Giesy J.P., Kannan K. Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls (PCBs): implications for risk assessment. Critical Rev. Toxicol. 28:(6):1998;511-569.
12. Gray L.E. Jr., Ostby J., Marshall R., Andrews J. Reproductive and thyroid effects of low-level polychlorinated biphenyl (Aroclor 1254) exposure. Fundam. App. Toxicol. 20:1993;288-294.
13. Hansen L.G. Stepping backward to improve assessment of PCB congener toxicities. Environ. Health Perspect. 106:(1):1998;171-189.
14. Hestermann E.V., Stegeman J.J., Hahn M.E. Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency. Toxicol. Appl. Pharmacol. 168:2000;160-172.
15. Kahn M.A., Lichtensteiger C.A., Faroon O., Mumtaz M., Schaeffer D.J., Hansen L.G. The hypothalamo-pituitary-thyroid (HPT) axis: a target of nonpersistent ortho-substituted PCB congeners. Toxicol. Sci. 65:2002;52-61.
16. Kodavanti P.R.S., Ward T.R., Derr-Yellin E.C., Mundy W.R., Casey A.C., Bush B., Tilson H.A. Congener-specific distribution of polychlorinated biphenyls in brain regions, blood, liver and fat of adult rats following repeated exposure to Aroclor 1254. Toxicol. Appl. Pharmacol. 153:1998;199-210.
17. Nagasawa, H., Fujiwara, K., Maejima, K., Matsushita, H., Yamada, J. and Yokoyama, A. (1983) Jikken Dobutsu Handbook, Handbook of Experimental Animals (in japanese). Tokyo: Yokendo.
18. Ness D.K., Schantz S.L., Moshtaghian J., Hansen L.G. Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat. Toxicol. Lett. 68:1993;311-323.
19. Refetoff S. Resistance to Thyroid Hormone. Werner and Ingbar's The Thyroid. seventh ed. 1996;1032-1045 Lippincott-Raven Publishers.
20. Safe S.H. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit. Rev. Toxicol. 24:(2):1994;87-149.
21. Safe S. Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds. Teratog. Carcinog. Mutagen. 17:1997;285-304.
22. Schantz S.L., Moshtaghian J., Ness D.K. Spatial learning deficits in adult rats exposed to ortho-substituted PCB congeners during gestation and lactation. Fundam. App. Toxicol. 26:1995;117-126.
23. Wong P.W., Pessah I.N. Noncoplanar PCB 95 alters microsomal calcium transport by an immunophilin FKB12-dependent mechanism. Mol. Pharmacol. 51:1997;693-702.