TGF-β2 stimulates cranial suture closure through activation of the Erk-MAPK pathway

Journal of Cellular Biochemistry

Volumn 98, Issue 4, 2006, Pages 981-991

  Lee, Sang Won ^a   Choi, Kang Young ^a   Cho, Je Yoel ^a   Jung, Sung Hwa ^a   Song, Kun Bae ^a   Park, Eui Kyun ^a   Choi, Je Yong ^a   Shin, Hong In ^a   Kim, Shin Yoon ^a   Woo, Kyung Mi ^b   Baek, Jeong Hwa ^b   Nam, Soon Hyeun ^a   Kim, Young Jin ^a   Kim, Hyun Jung ^a   Ryoo, Hyun Mo ^a,b  

^a Kyungpook National University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MITOGEN ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA2; TGFB2 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; BONE GROWTH; CALVARIA; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CRANIAL SUTURE; CRANIOFACIAL DEVELOPMENT; DURA MATER; ENZYME ACTIVATION; MOUSE; NONHUMAN; ORGAN CULTURE; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN FAMILY; SKULL; WOUND CLOSURE; ANIMAL; BONE DEVELOPMENT; CYTOLOGY; DRUG EFFECT; HUMAN; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CRANIAL SUTURES; DURA MATER; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; ORGAN CULTURE TECHNIQUES; OSTEOBLASTS; OSTEOGENESIS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2;

EID: 33745598562     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20773     Document Type: Article

References (43)

1. Baer MJ. 1954. Patterns of growth of the skull as revealed by vital staining. Hum Biol 26:80-126.
2. Bellus GA, Gaudenz K, Zackai EH, Clarke LA, Szabo J, Francomano CA, Muenke M. 1996. Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes. Nat Genet 14:174-176.
3. Debiais F, Lemonnier J, Hay E, Delannoy P, Caverzasio J, Marie PJ. 2001. Fibroblast growth factor-2 (FGF-2) increases N-cadherin expression through protein kinase C and Src-kinase pathways in human calvaria osteoblasts. J Cell Biochem 81:68-81.
4. Derynck R, Zhang YE. 2003. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425:577-584.
5. el Ghouzzi V, Le Merrer M, Perrin-Schmitt F, Lajeunie E, Benit P, Renier D, Bourgeois P, Bolcato-Bellemin AL, Munnich A, Bonaventure J. 1997. Mutations of the TWIST gene in the Saethre-Chotzen syndrome. Nat Genet 15:42-46.
6. Frenkel SR, Herskovits MS, Singh IJ. 1992. Fibroblast growth factor: Effects on osteogenesis and chondrogenesis in the chick embryo. Acta Anat 145:265-268.
7. Ghayor C, Rey A, Caverzasio J. 2005. Prostaglandin-dependent activation of ERK mediates cell proliferation induced by transforming growth factor β in mouse osteoblastic cells. Bone 36:93-100.
8. Gosain AK, Santoro TD, Song LS, Capel CC, Sudhakar PV, Matloub HS. 2003. Osteogenesis in calvarial defects: Contribution of the dura, the pericranium, and the surrounding bone in adult versus infant animals. Plast Reconstr Surg 112:515-527.
9. Howard TD, Paznekas WA, Green ED, Chiang LC, Ma N, Ortiz de Luna RI, Garcia Delgado C, Gonzalez-Ramos M, Kline AD, Jabs EW. 1997. Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome. Nat Genet 15:36-41.
10. Iseki S, Wilkie AO, Heath JK, Ishimaru T, Eto K, Morriss-Kay GM. 1997. Fgfr2 and osteopontin domains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF2. Development 124:3375-3384.
11. Ito Y, Yeo JY, Chytil A, Han J, Bringas P, Jr., Nakajima A, Shuler CF, Moses HL, Chai Y. 2003. Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Development 130:5269-5280.
12. Jabs EW, Muller U, Li X, Ma L, Luo W, Haworth IS, Klisak I, Sparkes R, Warman ML, Mulliken JB, Snead ML, Maxson R. 1993. A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis. Cell 75:443-450.
13. Jabs EW, Li X, Scott AF, Meyers G, Chen W, Eccles M, Mao JI, Charnas LR, Jackson CE, Jaye M. 1994. Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Nat Genet 8:275-279.
14. Kim HJ, Rice DP, Kettunen PJ, Thesleff I. 1998. FGF-, BMP-, and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development 125:1241-1251.
15. Kim HJ, Lee MH, Park HS, Park MH, Lee SW, Kim SY, Choi JY, Shin HI, Kim HJ, Ryoo HM. 2003. Erk pathway and activator protein 1play crucial roles in FGF2-stimulated premature cranial suture closure. Dev Dyn 227:335-346.
16. Lai CF, Cheng SL. 2002. Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-β in normal human osteoblastic cells. J Biol Chem 277:15514-15522.
17. Lai CF, Chaudhary L, Fausto A, Halstead LR, Ory DS, Avioli LV, Cheng SL. 2001. Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells. J Biol Chem 276:14443-14450.
18. Lemonnier J, Delannoy P, Hott M, Lomri A, Modrowski D, Marie PJ. 2000. The Ser252Trp fibroblast growth factor receptor-2 (FGFR-2) mutation induces PKC-independent downregulation of FGFR-2 associated with premature calvaria osteoblast differentiation. Exp Cell Res 256: 158-167.
19. Levine JP, Bradley JP, Roth DA, McCarthy JG, Longaker MT. 1998. Studies in cranial suture biology: Regional dura mater determines overlying suture biology. Plast Reconstr Surg 101:1441-1447.
20. Lin KY, Nolen AA, Gampper TJ, Jane JA, Opperman LA, Ogle RC. 1997. Elevated levels of transforming growth factors beta 2 and beta 3 in lambdoid sutures from children with persistent plagiocephaly. Cleft Palate Craniofac J 34:331-337.
21. Liu YH, Tang Z, Kundu RK, Wu L, Luo W, Zhu D, Sangiorgi F, Snead ML, Maxson RE. 1999. Msx2 gene dosage influences the number of proliferative osteogenic cells in growth centers of the developing murine skull: A possible mechanism for MSX2-mediated craniosynostosis in humans. Dev Biol 205:260-274.
22. Ma L, Golden S, Wu L, Maxson R. 1996. The molecular basis of Boston-type craniosynostosis: The Pro148 → His mutation in the N-terminal arm of the MSX2 homeodomain stabilizes DNA binding without altering nucleotide sequence preferences. Hum Mol Genet 5:1915-1920.
23. Marie PJ, Debiais F, Hay E. 2002. Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling. Histol Histopathol 17:877-885.
24. Massague J, Wotton D. 2000. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 19:1745-1754.
25. Mayahara H, Ito T, Nagai H, Miyajima H, Tsukuda R, Taketomi S, Mizoguchi J, Kato K. 1993. In vivo stimulation of endosteal bone formation by basic fibroblast growth factor in rats. Growth Factors 9:73-80.
26. Meyers GA, Day D, Goldberg R, Daentl DL, Przylepa KA, Abrams LJ, Graham JM, Jr., Feingold M, Moeschler JB, Rawnsley E, Scott AF, Jabs EW. 1996. FGFR2 exon IIIa and IIIc mutations in Crouzon, Jackson-Weiss, and Pfeiffer syndromes: Evidence for missense changes, insertions, and a deletion due to alternative RNA splicing. Am J Hum Genet 58:491-498.
27. Miyazono K, Kusanagi K, Inoue H. 2001. Divergence and convergence of TGF-beta/BMP signaling. J Cell Physiol 187:265-276.
28. Moursi AM, Winnard PL, Fryer D, Mooney MP. 2003. Delivery of transforming growth factor-beta2-perturbing antibody in a collagen vehicle inhibits cranial suture fusion in calvarial organ culture. Cleft Palate Craniofac J 40:225-232.
29. Muenke M, Schell U. 1995. Fibroblast-growth-factor receptor mutations in human skeletal disorders. Trends in Genetics 11:308-313.
30. Muenke M, Gripp KW, McDonald-McGinn DM, Gaudenz K, Whitaker LA, Bartlett SP, Markowitz RI, Robin NH, Nwokoro N, Mulvihill JJ, Losken HW, Mulliken JB, Guttmacher AE, Wilroy RS, Clarke LA, Hollway G, Ades LC, Haan EA, Mulley JC, Cohen MM, Jr., Bellus GA, Francomano CA, Moloney DM, Wall SA, Wilkie AOM, Zackai EH. 1997. A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome. Am J Hum Genet 60: 555-564.
31. Opperman LA, Sweeney TM, Redmon J, Persing JA, Ogle RC. 1993. Tissue interactions with underlying dura mater inhibit osseous obliteration of developing cranial sutures. Dev Dyn 198:312-322.
32. Opperman LA, Passarelli RW, Morgan EP, Reintjes M, Ogle RC. 1995. Cranial sutures require tissue interactions with dura mater to resist osseous obliteration in vitro. J Bone Miner Res 10:1978-1987.
33. Opperman LA, Passarelli RW, Nolen AA, Gampper TJ, Lin KY, Ogle RC. 1996. Dura mater secretes soluble heparin-binding factors required for cranial suture morphogenesis. In Vitro Cell Dev Biol 32:627-632.
34. Opperman LA, Nolen AA, Ogle RC. 1997. TGF-beta 1, TGF-beta 2, and TGF-beta 3 exhibit distinct patterns of expression during cranial suture formation and obliteration in vivo and in vitro. J Bone Miner Res 12:301-310.
35. Opperman LA, Adab K, Gakunga PT. 2000. TGF-β2 and TGF-β3 regulate fetal rat cranial suture morphogenesis by regulating rates of cell proliferation and apoptosis. Dev Dyn 219:237-247.
36. Reardon W, Winter RM, Rutland P, Pulleyn LJ, Jones BM, Malcolm S. 1994. Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome. Nat Genet 8:98-103.
37. Rice DP, Aberg T, Chan Y, Tang Z, Kettunen PJ, Pakarinen L, Maxson RE, Thesleff I. 2000. Integration of FGF and TWIST in calvarial bone and suture development. Development 127:1845-1855.
38. Roth DA, Longaker MT, McCarthy JG, Rosen DM, McMullen HF, Levine JP, Sung J, Gold LI. 1997. Studies in cranial suture biology: Part I. Increased immunoreactivity for TGF-β isoforms (β1, β2, and β3) during rat cranial suture fusion. J Bone Miner Res 12:311-321.
39. Takeuchi Y, Suzawa M, Kikuchi T, Nishida E, Fujita T, Matsumoto T. 1997. Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells. J Biol Chem 272:29309-29316.
40. Wilkie AOM, Slaney SF, Oldridge M, Poole MD, Ashworth GJ, Hockley AD, Hayward RD, David DJ, Pulleyn LJ, Rutland P, Malcolm S, Winter RM, Reardon W. 1995. Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome. Nat Genet 9:165-172.
41. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K. 1995. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270:2008-2011.
42. Yu L, Hebert MC, Zhang YE. 2002. TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J 21:3749-3759.
43. Zavadil J, Bitzer M, Liang D, Yang YC, Massimi A, Kneitz S, Piek E, Bottinger EP. 2001. Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta. Proc Natl Acad Sci USA 98:6686-6691.