Quaternary benzo[c]phenathridine alkaloids sanguinarine and chelerythrine do not affect transcriptional activity of aryl hydrocarbon receptor: Analyses in rat hepatoma cell line H4IIE.luc

Food and Chemical Toxicology

Volumn 44, Issue 9, 2006, Pages 1466-1473

  Dvořák, Zdeněk ^a   Sovadinová, Iva ^b   Bláha, Luděk ^b   Giesy, John P ^c   Ulrichová, Jitka ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Aryl hydrocarbon receptor; Chelerythrine; Safety; Sanguinarine; Transcription

Indexed keywords

ALKALOID DERIVATIVE; AROMATIC HYDROCARBON RECEPTOR; CHELERYTHRINE; DIOXIN; LUCIFERASE; SANGUINARINE;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL VIABILITY; CHEMOLUMINESCENCE; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY TEST; ENZYME ACTIVITY; HEPATOMA CELL; IN VITRO STUDY; MOUSE; NONHUMAN; RAT; TRANSCRIPTION INITIATION;

EID: 33745596789     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.04.016     Document Type: Article

References (21)

1. Dostal J., Taborska E., and Slavik J. Preparative column chromatography of quaternary benzophenanthridine alkaloids of Dicranostigma lactucoides. Fitoterapia. 63 (1992) 67-70
2. Dvorak Z., Modriansky M., Simanek V., Ulrichova J., Vicar J., Vrba J., and Walterova D. Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues. Toxicol Lett. 158 (2005) 164-165
3. Giuliana G., Pizzo G., Milici M.E., Musotto G.C., and Giangreco R. In vitro antifungal properties of mouthrinses containing antimicrobial agents. J Periodontol. 68 (1997) 729-733
4. Hilscherova K., Machala M., Kannan K., Blackenship A.L., and Giesy J.P. Cell Bioassays for detection of aryl hydrocarbon (AhR) and estrogen receptor (ER) mediated activity in environmental samples. Environ. Sci. Pollut. Res. 7 (2000) 159-171
5. Hong S.J., Jeong S.S., and Song K.B. Effects of sanguinaria in fluoride-containing dentifrices on the remineralisation of subsurface carious lesion in vitro. Int. Dent. J. 55 (2005) 128-132
6. Karp J.M., Rodrigo K.A., Pei P., Pavlick M.D., Andersen J.D., McTigue D.J., Fields H.W., and Mallery S.R. Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues. Toxicol. Lett. 158 (2005) 50-60
7. Kosina P., Walterova D., Ulrichova J., Lichnovsky V., Stiborova M., Rydlova H., Vicar J., Krecman V., Brabec M.J., and Simanek V. Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment. Food Chem. Toxicol. 42 (2004) 85-91
8. Long W.P., Pray-Grant M., Tsai J.C., and Perdew G.H. Protein kinase C activity is required for aryl hydrocarbon receptor pathway-mediated signal transduction. Mol. Pharmacol. 53 (1998) 691-700
9. Maiti M., Nandi R., and Chaudhuri K. Sanguinarine: a monofunctional intercalating alkaloid. FEBS Lett. 142 (1982) 280-284
10. Psotova J., Klejdus B., Vecera R., Kosina P., Kuban V., Vicar J., Simanek V., and Ulrichova J. A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 830 (2006) 165-172
11. Sanderson J.T., Aarts J.M., Brouwer A., Froese K.L., Denison M.S., and Giesy J.P. Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-O-deethylase induction in H4IIE cells: implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons. Toxicol Appl Pharmacol. 137 (1996) 316-325
12. Schmeller T., Latz-Bruning B., and Wink M. Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores. Phytochemistry 44 (1997) 257-266
13. Southon I.W., and Buckingham J. Dictionary of Alkaloids (1989), Chapman and Hall, London
14. Stiborova M., Simanek V., Frei E., Hobza P., and Ulrichova J. DNA adduct formation from quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine as revealed by the 32 P-postlabeling technique. Chem. Biol. Interact. 140 (2002) 231-242
15. Stoscheck C.M. Quantitation of protein. Methods Enzymol. 182 (1990) 50-68
16. Vrba J., Kosina P., Ulrichova J., and Modriansky M. Involvement of cytochrome P450 1A in sanguinarine detoxication. Toxicol. Lett. 151 (2004) 375-387
17. Vrzal R., Zdarilova A., Ulrichova J., Blaha L., Giesy J.P., and Dvorak Z. Activation of the aryl hydrocarbon receptor by berberine in HepG2 and H4IIE cells: Biphasic effect on CYP1A1. Biochem. Pharmacol. 70 (2005) 925-936
18. Walterova D., Ulrichova J., Valka I., Vicar J., Vavreckova C., Taborska E., Harjrader R.J., Meyer D.L., Cerna H., and Simanek V. Benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine: biological activities and dental care applications. Acta Univ. Palacki Olomuc. Fac. Med. 139 (1995) 7-16
19. Wang B.H., Lu Z.X., and Polya G.M. Inhibition of eukaryote protein kinases by isoquinoline and oxazine alkaloids. Planta Med. 63 (1997) 494-498
20. Williams M.K., Dalvi S., and Dalvi R.R. Influence of 3-methylcholanthrene pretreatment on sanguinarine toxicity in mice. Vet. Hum. Toxicol. 42 (2000) 196-198
21. Zdarilova A., Vrzal R., Rypka M., Ulrichova J., and Dvorak Z. Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells. Food Chem. Toxicol. 44 (2006) 242-249