Synthesis of indole derivatives as potential COX-2 inhibitors from N-substituted indolyl acetic acids via Curtius rearrangement

Bulletin of the Korean Chemical Society

Volumn 27, Issue 6, 2006, Pages 933-935

  Hwang, Ki Jun ^a   Lee, Seung Jae ^a   Kim, Beom Tae ^a   Raucher, Stanley ^b  

^a Chonbuk National University   (South Korea)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

COX 2; Curtius rearrangement; Indole; Levulinic acid

Indexed keywords

EID: 33745584355     PISSN: 02532964     EISSN: 12295949     Source Type: Journal    
DOI: 10.5012/bkcs.2006.27.6.933     Document Type: Article

References (8)

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2. (b) Talley, J. J.; Brown, D. L.; Carter, J. W.; Graneto, M. J.; Koboldt, C. M.; Zweifel, B. S.; Seibert, K. J. Med. Chem. 2000, 43, 775.
3. (c) Black, W. C.; Brideau, C.; Chan, C. C.; Carleson, S.; Chauret, N.; Clavean, D.; Ethier, D.; Riendeau, D.; Prasit, P. J. Med. Chem. 1999, 42, 1274.
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5. Kalguthar, A. S.; Marnett, A. B.; Crews, B. C.; Remmel, R. P.; Marnett, L. J. J. Med. Chem. 2000, 43, 2860.
6. For the good reference for the indole chemistry, refer to the book, Sundgerg, R. J. Indoles; Academic Press: New York, U.S.A., 1996.
7. Page, P. C.; Van Niel, M. B.; Prodger, J. C. Tetrahedron 1989, 45, 7643.
8. For the details to prepare this material, refer to the book. Phamaceutical Substances, 3rd ed.; Thieme Stuttgart: New York, 1999; vol. 1, pp 1002-1005.