Levetiracetam for cerebellar tremor in multiple sclerosis: An open-label pilot tolerability and efficacy study

Journal of Neurology

Volumn 253, Issue 6, 2006, Pages 762-766

  Striano, P ^a,b   Coppola, A ^a   Vacca, G ^a   Zara, F ^b   Brescia Morra, V ^a   Orefice, G ^a   Striano, S ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b G GASLINI INSTITUTE   (Italy)

Author keywords

Cerebellar tremor; Clinical trial; Levetiracetam; Multiple sclerosis

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CARBAMAZEPINE; ETIRACETAM; PRIMIDONE; TOPIRAMATE;

ADULT; AGITATION; ARTICLE; ATAXIA CLINICAL SCALE; CEREBELLUM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DISEASE COURSE; DISEASE DURATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG TOLERABILITY; FATIGUE; FEMALE; HUMAN; MALE; MULTIPLE SCLEROSIS; OPEN STUDY; PRIORITY JOURNAL; RATING SCALE; SIDE EFFECT; SOMNOLENCE; SPIRAL DRAWING SCALE; TREMOR; WILCOXON SIGNED RANKS TEST;

ACTIVITIES OF DAILY LIVING; ADULT; ANTICONVULSANTS; CEREBELLAR NEOPLASMS; DISABILITY EVALUATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PILOT PROJECTS; PIRACETAM; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC;

EID: 33745562173     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-006-0112-4     Document Type: Article

References (22)

1. Alusi SH, Worthington J, Glickman S, Bain PG (2001) A study tremor in multiple sclerosis. Brain 124:720-730
2. Sechi GP, Zuddas M, Piredda M, et al. (1989) Treatment of cerebellar tremors with carbamazepine: A controlled trial with long-term follow-up. Neurology 39:1113-1115
3. Sechi GP, Agnetti V, Sulas FMI, et al. (2003) Effects of topiramate in patients with cerebellar tremor. Prog Neuropsychopharmacol Biol Psychiatry 27:1023-1027
4. Leppik IE, Biton V, Sander JW, Wieser HG (2003) Levetiracetam and partial seizure subtypes: pooled data from three randomized, placebo-controlled trials. Epilepsia 44:1585-1587
5. Striano P, Manganelli F, Boccella P, Perretti A, Striano S (2005) Levetiracetam in patients with cortical myoclonus: A clinical and electrophysiological study. Mov Disord 20:1610-1614
6. Klitgaard H, Matagne A, Gobert J, Wulfert E (1998) Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. Eur J Pharmacol 353:191-206
7. Niespodziany I, Klitgaard H, Margineanu DG (2001) Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices. Neurosci Lett 306:5-8
8. Poser CM, Paty DW, Scheinberg L, et al. (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227-231
9. Deuschl G, Bain PG, Brin M (1998) Consensus statement of the movement disorder society on tremor. Ad hoc scientific committee. Mov Disord 13 (Suppl 3):S41-S48
10. Alusi SH, Worthington J, Glickman S, Findley LJ, Bain PG (2000) Evaluation of three different ways of assessing tremor in multiple sclerosis. J Neurol Neurosurg Psychiatry 68:756-760
11. Bain PG, Findley LJ, Atchinson P, et al. (1993) Assessing tremor severity. J Neurol Neurosurg Psychiatry 56:868-873
12. Pittock SJ, McClelland RL, Mayr WT, Rodriguez M, Matsumoto JY (2004) Prevalence of tremor in multiple sclerosis and associated disability in the Olmsted County population. Mov Disord 19:1482-1485
13. Lynch BA, Lambeng N, Nocka K, et al. (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci USA 101:9861-9866
14. Fuks B, Gillard M, Michel P, et al. (2003) Localization and photoaffinity of the levetiracetam binding site in rat brain and certain cell lines. Eur J Pharmacol 478:11-19
15. th Ed., pp 419-427
16. Bushara KO, Malik T, Exconde RE (2005) The effect of levetiracetam on essential tremor. Neurology 64:1078-1080
17. Handforth A, Martin FC (2004) Pilot efficacy and tolerability: a randomized, placebo-controlled trial of Levetiracetam for essential tremor. Mov Disord 19:1215-1221
18. Striano P, Orefice G, Brescia Morra V, et al. (2003) Epileptic seizures in Multiple Sclerosis: clinical and EEG correlations. Neurol Sci 24:322-328
19. Hawker K, Frohman E, Racke M (2003) Levetiracetam for phasic spasticity in multiple sclerosis. Arch Neurol 60:1772-1774
20. Deuschl G, Raethjen J, Lindemann M, Krack P (2001) The pathophysiology of tremor. Muscle Nerve 24:716-735 (Review)
21. Margineanu DG, Klitgaard H (2000) Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs. Pharmacol Res 42:281-285
22. Feys P, Helsen W, Liu X, Mooren D, Albrecht H, Nuttin B, Ketelaer P (2005) Effects of peripheral cooling on intention tremor in multiple sclerosis. J Neurol Neurosurg Psychiatry 76:373-379