Requisite role for interleukin-4 in the acceleration of fatty streaks induced by heat shock protein 65 or Mycobacterium tuberculosis

Circulation Research

Volumn 86, Issue 12, 2000, Pages 1203-1210

  George, Jacob ^a   Shoenfeld, Yehuda ^a   Gilburd, Boris ^a   Afek, Arnon ^a   Shaish, Aviv ^a   Harats, Dror ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

Author keywords

Atherosclerosis; Autoantibodies; Heat shock proteins; Interleukins; Mycobacterium tuberculosis

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; GAMMA INTERFERON; HEAT SHOCK PROTEIN 65; INTERLEUKIN 10; INTERLEUKIN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HUMORAL IMMUNITY; IMMUNIZATION; LYMPHOCYTE ACTIVATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

EID: 0034705376     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.86.12.1203     Document Type: Article

References (31)

1. Ross R. Atherosclerosis: an inflammatory condition. N Engl J Med. 1999; 340:115-126.
2. Libby P, Hansson GK. Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions. Lab Invest. 1991;64:5-15.
3. Wick G, Schett G, Amberger A, Kleindienst R, Xu Q. Is atherosclerosis an immunologically mediated disease? Immunol Today. 1995;16:27-33.
4. Ellis J. Proteins as molecular chaperones. Nature. 1987;328:378-379.
5. Winfield JB. Stress proteins, arthritis, and autoimmunity. Arthritis Rheum. 1989;32:1497-1504.
6. Jones DB, Hunter NR, Duff GW. Heat shock protein 65 as a β cell antigen of insulin dependent diabetes. Lancet. 1990;336:583-585.
7. Xu Q, Willeit J, Marosi M, Kleindienst R, Oberhollenzer F, Kiechl S, Stulnig T, Luef G, Wick G. Association of serum antibodies to heat shock protein 65 with carotid atherosclerosis. Lancet. 1993;341:255-259.
8. Xu Q, Dietrich H, Steiner HJ, Gown AM, Schoel B, Mikuz G, Kaufman SHE, Wick G. Induction of arteriosclerosis in normocholesterolemic mice rabbits by immunization with heat shock protein 65. Arterioscler Thromb. 1992;12:789-799.
9. Xu Q, Kleindienst R, Waitz H, Dietrich H, Wick G. Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65. J Clin Invest. 1993;91:2693-2702.
10. George J, Shoenfeld Y, Afek A, Gilburd B, Keren P, Shaish A, Kopolovic Y, G. Wick, Harats D. Enhanced fatty streak formation in C57BL/6J mice by immunization with heat shock protein 65. Arterioscler Thromb Vasc Biol. 1999;19:505-510.
11. Kol A, Sukhova G, Lichtman AH, Libby P. Chlamydial heat shock protein 60 localizes in atheroma and regulates macrophage tumor necrosis factor-α and matrix metalloproteinase expression. Circulation. 1998;98:300-307.
12. Kol A, Bourcier T, Lichtman AH, Libby P. Chlamydial and human heat shock protein activates human vascular endothelium, smooth muscle cells and macrophages. J Clin Invest. 1999;103:571-577.
13. + T-cells. Annu Rev Immunol. 1994;12:635-673.
14. Paul WE, Seder R. Lymphocyte responses and cytokines. Cell. 1994;76: 241-251.
15. Paigen B, Morrow A, Brandon C, Mitchell D, Holmes PA. Variation in susceptibility to atherosclerosis among inbred strain of mice. Atherosclerosis. 1985;57:65-73.
16. Rocken M, Rack M, Shevach E, IL-4 induced immune deviation as antigen specific therapy for inflammatory autoimmune disease. Immunol Today. 1996;17:225-231.
17. Mueller R, Krahl T, Sarvetnick N. Pancreatic expression of IL-4 abrogates insulinitis and autoimmune diabetes in non-obese diabetic (NOD) mice. J Exp Med. 1996;184:1093-1099.
18. Tang H, Sharp GC, Peterson KE, Braley-Mullen H. Induction of granulomatous experimental autoimmune thyroiditis in IL-4 gene-disrupted mice. J Immunol. 1998;160:155-162.
19. Balasa B, Deng C, Lee J, Christadoss P, Sarvetnick N. The Th2 cytokine IL-4 is not required for the progression of antibody dependent autoimmune myasthenia gravis. J Immunol. 1998;161:2856-2862.
20. Ramanathan S, de Kozak Y, Saoudi O, Goureau P, van der Maide H, Druet P, Bellon B. Recombinant IL-4 aggravates experimental autoimmune uveoretinitis in rats. J Immunol. 1996;157:2209-2216.
21. Jacobs MJ, van den Hoek AE, ven Lent PL, ven den Loo FA, van de Putte, van den Berg WB. Role of IL-2 and IL-4 in exacerbation of murine antigen induced arthritis. Immunology. 1990;83:390-396.
22. Abbas A, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature. 1996;383:377-386.
23. Xu Q, Kiechl S, Mayr M, Metzler B, Egger G, Oberhollenzer F, Willeit J, Wick G. Association of serum antibodies to heat shock protein 65 with carotid atherosclerosis: clinical significance determined in a follow-up study. Circulation. 1999;100:1169-1174.
24. Schett G, Xu Q, Amberger A, Van der Zee R, Recheis H, Willeit J, Wick G. Antibodies against heat shock protein 60 mediate endothelial cytotoxicity. J Clin Invest. 1995;96:2569-2577.
25. Elhage R, Maret A, Pieraggi MT, Thiers JC, Arnal JF, Bayard F. Differential effects of interleukin-1 receptor antagonist and tumor necrosis factor binding protein on fatty streak formation in apolipoprotein E deficient mice. Circulation. 1998;97:242-244.
26. Iademarco MF, Barks JL, Dean DC. Regulation of vascular cell adhesion molecule expression by IL-4 and TNF-α in cultured endothelial cells. J Clin Invest. 1995;95:264-271.
27. Barks JL, McQuillan JJ, Iademarco MF. TNF-α and IL-4 synergistically increase vascular adhesion molecule 1 expression in cultured vascular smooth muscle cells. J Immunol. 1995;95:264-271.
28. Zhou X, Paulsson G, Stemme S, Hansson GK. Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice. J Clin Invest. 1998;101: 1117-1225.
29. Conrad DJ, Kuhn H, Mulkins M, Highland E, Sigal E. Specific inflammatory cytokines regulate the expression of human monocyte 15-LO. Proc Natl Acad Sci U S A. 1992;89:217-221.
30. Cornicelli JA, Trivedi BK. 15-Lipoxygenase and its inhibition: a novel therapeutic target for vascular disease. Curr Pharm Des. 1999;5:11-20.
31. -/- mice: decreasing density with disease progression. Arterioscler Thromb Vasc Biol. 1996; 16:1013-1018.